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Good Night, Sleep Tight: Understanding the Importance of Sleep
1. Good Night,
Sleep Tight:
Understanding the
Importance of Sleep
Conversations at the Royal
Elliott Lee MD, FRCP(C)
D. ABPN Sleep Medicine, Addiction Psychiatry
D. Amer Board of Sleep Medicine
Assistant Professor, Royal Ottawa MHC
December 19, 2013
2. Outline
• Functions of sleep
• Factors affecting sleep
- Quantity
- Quality
- Timing
• Is sleep an issue for you?
• Obstructive sleep apnea, Narcolepsy
• How to improve sleep
4. Approximately what percentage of our (adult) lives will
be spent sleeping?
A) 20%
B) 25%
C) 33%
D) 40%
E) 50%
5. Approximately what percentage of our (adult) lives will
be spent sleeping?
A) 20%
B) 25%
C) 33%
D) 40%
E) 50%
6. Why Study Sleep?
We spend 1/3 of our lives sleeping
Severe health consequences - DEATH!
Sleep deprivation costs
$150 BILLION/yr in lost
productivity
(Nat’l Commission on Sleep Disorders, 2003)
7. Functions of Sleep
Body /brain repair
- Increased resilience to
stress/injury
Pain Reduction
Mood regulation
Diminished anxiety
Memory and learning
Immune competence
14. Sleep Deprivation
According to the most recent General Social Survey
done by Statistics Canada (2010), 46% percent of
Canadians will cut back on sleep in order to add time
to their days.
15. Sleep Deprivation
There is a conflict between the biological imperative
for sleep and the social demand for performance. This
poses a fundamental question:
What happens to performance when the pressure for
sleep is increased?
16. Sleep Quantity
Too little – equivalent to functioning with 0.05 blood
alcohol level (<6 hours)1
<7 hours – decrements can be seen in performance
Cognitive function > speed > accuracy2,3
1Williamson
AM and Feyer AM. Occup Environ Med 2000; 57; 649-55
2Koslowsky M and Babkoff H. Chronobiol Intl. 1992; 9(2); 132-6
3Reilly T and Edwards B. Physiology and Behaviour. 2007; 90; 274-84
17. Sleep Disorders Socioeconomic Consequences
More than 100,000 motor vehicle accidents annually
are sleep-related (US).
“Toronto syndrome”
18. Psychomotor Vigilance Task (PVT) errors with
cumulative sleep deprivation
Dinges et al Sleep, 1997; 20(4), 267-77
19. Challenger Disaster
3 Mile Island
Chernobyl
Exxon Valdez
Medical Errors
Transportation
Industry
20. Daylight Savings and Traffic Accidents
Coren S. N Engl J Med. 1996 Apr 4; 334(14): 924
21. Sleep Deprivation and Wt gain?
Women who sleep <5 hours per night, gained 2.5
lbs, cf. to women sleeping 7 hours/night
Relative risk for obesity (BMI > 30 kg/m2)
5 hour sleepers = 1.15 cf. to 7+ hours
Studied >68 000 women (Nurses Health Study) for 16
years
Hormones? Basal metabolic rate?
22. Sleep Deprivation and Children
Not the same as adults
May be “hyperactive”
- fidget
- poor attention
- cranky
27. Process S(leep)
Homeostatic control
“The longer we’re awake, the more sleep debt we
accumulate i.e. the sleepier we become”
The sleepier we are, the more deficits are seen
To date, there is no surrogate available for good quality
sleep.
28. Process S(leep)
Homeostatic control
“The longer we’re awake, the more sleep debt we
accumulate i.e. the sleepier we become”
The sleepier we are, the more deficits are seen
To date, there is no surrogate available for good quality
sleep.
29. Process C(ircadian)
Sleep tendencies follow a circadian (daily) rhythm
This is controlled by a central “biological clock”
Several inputs also influence this clock, especially
- Light
- Melatonin
33. Consequences of Asynchronous Sleep
Impaired continuity of
sleep
↓ alertness
↑cognitive errors
Like “hitting a tennis ball
off the centre of the
racquet” – sleep is not as
efficient, and sleep
architecture is disrupted
Jet lag, shift work
34. Who is more likely to do rotating or evening shifts in
Canada, men or women?
35. Who is more likely to do rotating or evening shifts in
Canada, men or women?
WOMEN
36. Women are more likely to work
rotating shifts or evening shifts
Men
Women
Irregular
25%
Other
13%
Other
12%
Evening
14%
Irregular
35%
Evening
10%
Night
8%
Night
8%
Rotating
41%
Rotating
34%
Source: Williams C. Worklife Balance of Shift Workers, Stats Canada General Social Survey, 2005
37. Shift Work
International Agency on Research and Cancer (IRAC)
classified shift work as a probable carcinogen in 2007.
40-50% increase in breast cancer risk with >20-30
years of shift work exposure.
Melatonin thought to play a key role; reduces estrogen
levels and shown to have anticancer properties.
Megdal et al. Eur J Cancer. 2005; 41: 2023-32
Grundy A et al. Occup Environ Med. 2013; 70: 831-8
Shernhammer ES and Hankinson SE. Cancer Epidemiol Biomarkers Prev 2009; 18: 74-9
38. Is sleep an issue for you?
Do you feel satisfied with the quality of your
sleep?
Do you frequently fall asleep if given a sleep
opportunity (a sleep opportunity is defined as a
quiet, dark environment for at least 10 minutes)?
Do you usually need an alarm clock to wake you?
Do you tend to catch up on sleep during the
weekends?
Once awake, do you feel tired most mornings?
Do you frequently take naps during the day?
39. Is sleep an issue for you?
When you can get it, do you consistently sleep
more than 9.5 hours per night?
Do you feel lethargic or slow throughout the day?
Do you sleep longer during times of depression,
anxiety and stress?
Do you snore?
Do your legs bother you at bedtime, interfering
with your sleep?
40. What Happens at the Sleep Lab…
ROMHC: 5 bed clinical lab, 4 bed research lab
STEPS:
1) → Referral
2) → Consultation with a Sleep Specialist
3) → Overnight Sleep Study
4) → Data is Analyzed by RPSGTs
5) → Results Appt with a Sleep Specialist
41. How Do We Measure Sleep in the
Laboratory?
Electrophysiology
EEG – brainwaves (Central & Occipital Leads)
EOG – eye movements
EMG – muscle tone
EKG – heart
Breathing:
1)Airflow
& 2) Effort: Thoracic & Abdominal
Blood oxygen saturation (SaO2)
Audio-visual recording
42.
43.
44.
45.
46. Obstructive Sleep Apnea (OSA)
Definition:
The presence of abnormal breathing
disruptions/cessations (apneas) during sleep
Sleep is disrupted temporarily, usually without recall.
As a result, sleep deprivation and/or excessive daytime
sleepiness occur, usually with snoring at night
Up to 25% of men and 9% of women are thought to be
affected, with 90% of patients likely undiagnosed1
50% of snorers are thought to have OSA2
Strongly associated with cardiac disease
1Young et al. N Eng J Med, 1993; 328(17):
2Lugaresi et al. Sleep, 1980; 3(3-4): 221-4
1230-5
49. Motor vehicle accidents
Hypertension
OSA Consequences
Impaired
glucose
control
Irritability, mental illness e.g. depression
Heart attack and stroke
Memory problems
51. OSA and Attractiveness?
Treatment of OSA with
CPAP has been shown to
improve attractiveness
Perceived to be
- More alert
- More youthful
- Less forehead creases
Chervin R et al. J Clin Sleep Med, 2013; 9(9): 845-52
52. All of the following famous people suffer from a
sleep disorder. Which of these famous people
suffers from obstructive sleep apnea? (Choose
all that apply):
A
B
C
D
E
53. All of the following famous people suffer from a
sleep disorder. Which of these famous people
suffers from obstructive sleep apnea? (Choose
all that apply):
A
B
C
D
E
54.
55. Narcolepsy
A pathologic disorder of sleepiness during the day –
key symptom – sleepiness
May have insomnia at nighttime
Affects about 1/2000 people
Very underdiagnosed; difficult to recognize
80% may have cataplexy, a REM sleep intrusion
phenomenon on wakefulness
Related to cerebrospinal fluid deficiency of hypocretin
(orexin)
59. All of the following famous people suffer from a
sleep disorder. Which of these famous people
suffers from narcolepsy?
A
B
C
D
E
60. All of the following famous people suffer from a
sleep disorder. Which of these famous people
suffers from narcolepsy?
A
B
C
D
E
61. How to Improve Sleep
Get adequate quantity of sleep (7.5-8.5 hrs)
Regular sleep/wake times – timing/routine important
Develop a relaxing pre sleep ritual
- relaxation exercises can be helpful
- avoid stressful/stimulating activities prior to sleep
Avoiding prolonged naps* in the day
Bed – only for sleep (and romance!)
Avoid clock watching
Rule out sleep disorder, psychiatric disorder
62. How to Improve Sleep
Sleep Environment
- Avoid environmental disturbances
- Partner/Children
- Roommate
- External noises – phones, texting, external
(white noise generator may drown out)
- Avoid bright light in evenings
- Temperature – slightly cooler (<21-22oC) is better.
drop in temperature facilitates sleep onset
- Bed should be comfortable – consider memory foam
mattresses/pillows; queen or king size beds
Quiet. Dark. Cool. Comfortable.
64. Which of the following substances has the highest
amount of caffeine?
A) Red Bull, 250 mL
B) Coca Cola, 1 L
C) Starbucks Coffee, Grande (360 mL)
D) Green Tea, 300 mL
E) Caffeine pill, (200 mg tab)
65. Which of the following substances has the highest
amount of caffeine?
A) Red Bull, 250 mL
B) Coca Cola, 1 L
C) Starbucks Coffee, Grande (360 mL)
D) Green Tea, 300 mL
E) Caffeine pill, (200 mg tab)
66. Caffeine – a Canadian Love Affair
Starbucks coffee(20 oz)
400 mg
Second Cup coffee (20 oz)
400 mg
Tim Horton’s coffee (20 oz)
270 mg
Instant coffee (8 oz)*
95 mg
Tea (leaf or bag, 8 oz)
50 mg
Mountain Dew (12 oz)
55 mg
Coca Cola (12 oz)
45 mg
Red Bull (250 ml)
80 mg
Sources: National Coffee Association, National Soft Drink Association, Tea Council of the USA, and information
provided by food, beverage, and pharmaceutical companies and J.J. Barone, H.R. Roberts (1996) "Caffeine
Consumption." Food Chemistry and Toxicology, vol. 34, pp. 119-129.
67. Summary
Sleep is important to consider for performance
Good sleep can improve performance
- Cognition/memory
- Accuracy
- Speed
- Health/Decrease sick days (immune competence)
- Improve mood, anxiety, resilience
Sleep variables to consider: Quantity, Quality, Timing
Rule out sleep disorder
Details are important; BALANCE – key to success
68. When the time to perform has come, the time to prepare
has past.
Bob Bowman, coach of Michael Phelps
Cumulative Sleepiness, Mood Disturbance, And Psychomotor Vigilance Performance Decrements During A Week Of Sleep Restricted To 4-5 Hours Per Night *†‡David F. Dinges, ‡Frances Pack, ‡Katherine Williams, *Kelly A. Gillen, *John W. Powell, *Geoffrey E. Ott, *Caitlin Aptowicz and †‡§Allan I. Pack*Unit for Experimental Psychiatry, †Division of Sleep and Chronobiology, Department of Psychiatry, ‡Center for Sleep and Respiratory Neurobiology and §Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, U.S.A.Volume : 20 Issue : 04 Pages : 267-277 • View full text• Email to a friendCumulative Sleepiness, Mood Disturbance, And Psychomotor Vigilance Performance Decrements During A Week Of Sleep Restricted To 4-5 Hours Per
To the Editor: It has become increasingly clear that insufficientsleep and disrupted circadian rhythms are a major publichealth problem. For instance, in 1988 the cost of sleeprelatedaccidents exceeded $56 billion and included 24,318deaths and 2,474,430 disabling injuries.1 Major disasters, includingthe nuclear accident at Chernobyl, the Exxon Valdez oilspill, and the destruction of the space shuttle Challenger, havebeen linked to insufficient sleep, disrupted circadian rhythms,or both on the part of involved supervisors and staff.2,3 It hasbeen suggested that as a society we are chronically sleepdeprived4and that small additional losses of sleep may haveconsequences for public and individual safety.2We can use noninvasive techniques to examine the effectsof minor disruptions of circadian rhythms on normal activitiesif w e take advantage of annual shifts in time keeping.More than 25 countries shift to daylight savings time eachspring and return to standard time in the fall. The spring shiftresults in the loss of one hour of sleep time (the equivalent interms of jet lag of traveling one time zone to the east), whereasthe fall shift permits an additional hour of sleep (the equivalentof traveling one time zone to the west). A lthough onehour’s change may seem like a minor disruption in the cycleof sleep and wakefulness, measurable changes in sleep patternpersist for up to five days after each time shift.5 This leads tothe prediction that the spring shift, involving a loss of anhour’s sleep, might lead to an increased number of “microsleeps,”or lapses of attention, during daily activities and thusmight cause an increase in the probability of accidents, especiallyin traffic. The additional hour of sleep gained in the fallmight then lead conversely to a reduction in accident rates.We used data from a tabulation of all traffic accidents inCanada as they were reported to the Canadian Ministry ofTransport for the years 1991 and 1992 by all 10 provinces. Atotal of 1,398,784 accidents were coded according to the dateof occurrence. Data for analysis were restricted to the Mondaypreceding the week of the change due to daylight savingstime , the Monday immediately a fter, a nd the Monday o neweek after the change, for both spring and fall time shifts.Data from the province of Saskatchewan were excluded becauseit does not observe daylight savings time. The analysisof the spring shift included 9593 accidents and that of the fallshift 12,010. The resulting data are shown in Figure 1.The loss of one hour’s sleep associated with the spring shiftto daylight savings time increased the risk of accidents. TheMonday immediately after the shift showed a relative risk of1.086 (95 percent confidence interval, 1.029 to 1.145; x29.01,1 df; P0.01). As compared with the accident rate a week later,the relative risk for the Monday immediately after the shift was1.070 (95 percent confidence interval, 1.015 to 1.129; x26.19,1 df; P0.05). Conversely, there was a reduction in the risk oftraffic accidents after the fall shift from daylight savings timewhen an hour of sleep was gained. In the fall, the relative riskon the Monday of the change was 0.937 (95 percent confidenceinterval, 0.897 to 0.980; x28.07, 1 df; P0.01) when comparedwith the preceding Monday and 0.896 (95 percent confidenceinterval, 0.858 to 0.937; x223.69; P0.001) whencompared with the Monday one week later. Thus, the springshift to daylight savings time, and the concomitant loss of onehour of sleep, resulted in an average increase in traffic accidentsof approximately 8 percent, whereas the fall shift resultedin a decrease in accidents of approximately the same magnitudeimmediately after the time shift.These data show that small changes in the amount of sleepthat people get can have major consequences in everyday activities.The loss of merely one hour of sleep can increase therisk of traffic accidents. It is likely that the effects are due tosleep loss rather than a nonspecific disruption in circadianrhythm, since gaining an additional hour of sleep at the falltime shift seems to decrease the risk of accidents.Vancouver, BC V6T 1Z4, STANLEY COREN, PH.D.Canada University of British Columbia
Anxiety we see all the time in the sleep lab – sleeping in a foreign environmentChances are 1-3 people here may struggle with RLS which may give people problems falling/staying asleep
To the question: In an economy that often demands 24/7 activity, shift work remains common both among men and women. Among the different types of shift work are rotating and evening shifts. Are women more likely or less likely to work rotating shifts and evening shifts?The correct answer is A: While proportionately fewer women work irregular shifts (25% vs. 35% for men), they are more likely to work rotating shifts (41% vs. 34%) or evening shifts (14% vs. 10%).Among full-time shift workers, women were more likely than men to work rotating or evening shiftsIn 2005, over 3 million full-time workers worked something other than a regular daytime schedule, with two-thirds of them working a rotating or irregular shift. Just as women’s share of full-time work has increased in the labour market in general, so too has their share of full-time shift work. In 2005, about 37% of full-time shift workers were women, up from about 33% in 1992. Some occupations are more commonly associated with shift work. Almost half of workers in health-related occupations and two-thirds of those in protective services worked shift.Among full-time shift workers, women were more likely than men to work rotating or evening shiftsIn 2005, over 3 million full-time workers worked something other than a regular daytime schedule, with two-thirds of them working a rotating or irregular shift. Just as women’s share of full-time work has increased in the labour market in general, so too has their share of full-time shift work. In 2005, about 37% of full-time shift workers
The time between the photographsand Epworth scores obtained initially, and then againafter at least 2 months of successful CPAP use, was 5.8 ± 1.8months. The mean Epworth score was 13.5 ± 2.3 at baselineand 5.6 ± 2.7 after use of CPAP, resulting in a mean change of-7.0 ± 4.1 (paired T-test p < 0.0001). Adequate adherence withPAP was confirmed electronically for all but one subject whosedata card failed to function properly. Among the 30 nights justprior to the post-PAP images, the percent of nights that showed≥ 4 h of use ranged from 70% to 100% (mean 89% ± 10%).Mean hours of PAP use, on nights used, was 6.3 ± 0.6.
Jocelyn Wildenstein, a wealthy socialite featured in this photo montage is 71 years old. She has had numerous plastic surgeries done to her face to create a more “cat like look”. She has sometimes been referred to as “the Lion Queen” or the “Catwoman”.
Jocelyn Wildenstein, a wealthy socialite featured in this photo montage is 71 years old. She has had numerous plastic surgeries done to her face to create a more “cat like look”. She has sometimes been referred to as “the Lion Queen” or the “Catwoman”.
Jocelyn Wildenstein, a wealthy socialite featured in this photo montage is 71 years old. She has had numerous plastic surgeries done to her face to create a more “cat like look”. She has sometimes been referred to as “the Lion Queen” or the “Catwoman”.
Jocelyn Wildenstein, a wealthy socialite featured in this photo montage is 71 years old. She has had numerous plastic surgeries done to her face to create a more “cat like look”. She has sometimes been referred to as “the Lion Queen” or the “Catwoman”.
US winter olympic team – used these measures; apollo anton ohno Michael phelps swears by napping and getting as much sleep as he canhttp://sportsblog.projo.com/2008/08/michael-phelps.htmlhttp://health.usnews.com/blogs/on-fitness/2008/06/26/the-athletes-legal-performance-aid-sleep.html
Improved cycling time-trial performance after ingestion of a caffeine energy drink.Ivy JL, Kammer L, Ding Z, Wang B, Bernard JR, Liao YH, Hwang J.Department of Kinesiology and Health Education, University of Texas, Austin, TX 78712-0360, USA.CONTEXT: Not all athletic competitions lend themselves to supplementation during the actual event, underscoring the importance of preexercise supplementation to extend endurance and improve exercise performance. Energy drinks are composed of ingredients that have been found to increase endurance and improve physical performance. PURPOSE: The purpose of the study was to investigate the effects of a commercially available energy drink, ingested before exercise, on endurance performance. METHODS: The study was a double-blind, randomized, crossover design. After a 12-hr fast, 6 male and 6 female trained cyclists (mean age 27.3 +/- 1.7 yr, mass 68.9 +/- 3.2 kg, and VO2 54.9 +/- 2.3 ml x kg-1 x min-1) consumed 500 ml of either flavored placebo or Red Bull Energy Drink (ED; 2.0 g taurine, 1.2 g glucuronolactone, 160 mg caffeine, 54 g carbohydrate, 40 mg niacin, 10 mg pantothenic acid, 10 mg vitamin B6, and 10 microg vitamin B12) 40 min before a simulated cycling time trial. Performance was measured as time to complete a standardized amount of work equal to 1 hr of cycling at 70% Wmax. RESULTS: Performance improved with ED compared with placebo (3,690 +/- 64 s vs. 3,874 +/- 93 s, p < .01), but there was no difference in rating of perceived exertion between treatments. b-Endorphin levels increased during exercise, with the increase for ED approaching significance over placebo (p = .10). Substrate utilization, as measured by open-circuit spirometry, did not differ between treatments. CONCLUSION: These results demonstrate that consuming a commercially available ED before exercise can improve endurance performance and that this improvement might be in part the result of increased effort without a concomitant increase in perceived exertion.PMID: 19403954 [PubMed - indexed for MEDLINE]Related articlesFailure of protein to improve time trial performance when added to a sports drink.Med Sci Sports Exerc. 2006 Aug; 38(8):1476-83. [Med Sci Sports Exerc. 2006]Effects of microhydrin supplementation on endurance performance and metabolism in well-trained cyclists.Int J Sport NutrExercMetab. 2004 Oct; 14(5):560-73. [Int J Sport NutrExercMetab. 2004]Effect of Red Bull energy drink on repeated Wingate cycle performance and bench-press muscle endurance.Int J Sport NutrExercMetab. 2007 Oct; 17(5):433-44. [Int J Sport NutrExercMetab. 2007]Carbohydrate-electrolyte feedings improve 1 h time trial cycling performance.Int J Sports Med. 1997 Feb; 18(2):125-9. [Int J Sports Med. 1997]Review[The effects of energy drinks on cognitive performance]TijdschrPsychiatr. 2008; 50(5):273-81. [TijdschrPsychiatr. 2008]» See reviews... | » See all...Patient Drug InformationNiacin (Advicor® , Niacor® , Niaspan® ) Niacin is used with diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in your blood. Niacin is also used to prevent and treat pellagra (niacin defic... Glipizide (Metaglip, Glucovance, Avandamet, ...) In patients with diabetes or hyperlipidemia, how do combination drugs compare in improving long-term health? Source: AHFS Consumer Medication Information