This document discusses parvovirus B19, which is a single-stranded DNA virus that causes fifth disease or slapped cheek appearance. It has the smallest viral genome and can cause aplastic crisis in children with chronic hemolytic anemia or arthralgia and arthritis in adults. Transplacental transmission occurs in 30% of cases and can result in nonimmune fetal hydrops.
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Most Common Pox Virus Affecting Humans
1.
2. MOST COMMON POX VIRUS AFFECTING HUMANS
CANNOT BE GROWN IN EGGS TISSUE CULTURE OR HUMANS
MCV 1 TO 4
MCV1 MOST PREVALENT
MCV2 IN ADULTS ONLY (SEXUALLY TRANSMITTED)
3. PINK OR PEARLY WHITE NODULE WITH CENTRAL UMBILICATION
NO ASSOCIATED INFLAMMATION
4.
5. ENVELOPED dsDNA
LATENT INFECTIONS
COWDRY TYPE A INCLUSION
CAUSE LATENT INFECTIONS
8. DOUBLE STRANDED ENVELOPED DNA
HSV1 PRODUCES LESION ABOVE WAIST
HSV2 LESION BELOW WAIST
BOTH HSV1 & HSV2 CAN CAUSE GENITAL & ORAL FACIAL INFECTION
BUT REACTIVATION @ ORAL FACIAL SITE IS DUE TO HSV1 & @ GENITAL SITE WITH
HSV2
HSV1 ACQUIRE IN EARLY LIFE
HSV2 IS ACQUIRED AFTER PUBERTY
9.
10. IP 6-8 DAYS
PRIMARY HSV INFECTION IS MORE SEVERE & ASSOCIATED WITH
SYSTEMIC SYMPTOMS & COMPLICATIONS THAN REACTIVATION FROM
LATENT INFECTION
11. HSV1 MOST COMMON CAUS EA/C SPORADIC VIRAL ENCEPHALITIS
HSV2 CAUSATION CERVICAL CANCER
12. • ORAL FACIAL
• GINGIVOSTOMATITIS &
PHARYNGITIS ARE
MOST COMMON
MANIFESTATION
• HERPES LABIALIS IS
MOST COMMON
MANIFESTATION OF
REACTIVATION
• GENITAL
• MOSTLY HSV2
• MC SITE
• PENIS IN MALES
• CERVIX & URETHRA IN
FEMALE
• PAINFUL & B/L
• TENDER INGUINAL
LYMPHADENOPATHY
• HERPETIC
WHITLOW
• OCCURS IN
DOCTORS
• INFECTION OF
FINGER
14. MC CAUSE OF BLINDENSS IN USA
FOLLICULAR CONJUNCTIVITIS
KERATITIS
DENDRITIC ULCER
15. IN NEWBORN BORN TO MOTHERS WITH VAGINAL HSV2 INFECTION
MOST OF THE CASES BY HSV2
VISCERAL & CNS INFECTION
SKIN LESIONS ARE THE MOST COMMONLY RECOGNIZED FEATURES
16. TZANCK SMEAR
MULTINUCLEATED GIANT CELL
GEIMSA STAIN
COWDRY TYPE A INTRANUCLEAR INCLUSION
HSV PCR MOST SENSITIVE
ISOLATION OF VIRUS ON HUMAN FIBROBLAST MOST SPECIFIC
RX
ACYCLOVIR
17. HERPES VIRUS 4
IMN /KISSING DISEASE
MC IN EARLY CHILDHOOD WITH A SECOND PEAK DURING LATE
ADOLESENCE
TRANSMITTED BY SALIVA /ORAL SECRETIONS OF INFECTED PERSON
18.
19. MEMORY B CELLS ARE THE RESERVOIR OF EBV
Although B lymphocytes are infected by the virus, the characteristic atypical cells
are activated suppresser T cells explaining the paracortical location (normally a T
cell zone) in the lymph node atypical lymphocytes
Lymphocytosis with more than 20 % atypical lymphocytosis
20. MC SYMPTOM SORETHROAT
MC SIGN LYMPHADENOPATHY INFECTIOUS MONONUCLEOSIS
MC COMPLICATION MENINGITIS / ENCEPHALITIS
21. BURKITTS LYMPHOMA
HODGKINS DS (MIXED XELLULARITY)
NASOPHARYNGEAL CARCINOMA
ORAL HAIRY LEUKOPLAKIA IN AIDS PATIENT
X LINKED LYMPHOPROLIFERATIVE SYNDROME (duncans syndrome)
22. Heterophile ab test
Paul bunnel test
EBV specific Ab test
Anti viral capsid ag
Anti EBV nuclear Ag
Anti early Ag
23.
24. Salivary gland virus
Largest virus among herpes virus
Characterised by enlargement of infected cells (cytomegalic cells) & intranuclear
inclusion
Owls eye inclusion bodies
26. Once infected individual carries CMV for life
Mc organism causing IU infection
Mc organism complicating organ transplantation
27.
28. Most common cause of congenital infection
It causes
Triad
Petechiae
Hepatosplenomegaly
Jaundice
It can also cause intracerebral calcification IUGR choreoretinitis
thrombocytopenia /inguinal hernia
Diagnosis
Virus isolation from urine saliva
PCR of viral genome
29. Maximum risk of infection after kidney transplant after 1-4 months after
transplantation
Mc presentation is fever leukopenia HSM
Mc presentation after BM transplantation is interstitial pneumonia
36. ADENOVIRUS CAUSES INFECTIONS OF THE RESPIRATORY TRACT &
LESS OFTEN OF THE INTESTINE
MOST COMMON MANIFESTATION IN CHILDREN A/C URTI & RHINITIS
MOST COMMON MANIFESTATION IN ADULTS IS ARDS
37. NONENVELOPED DNA VIRUS
PAPILLOMA VIRUS
POLYOMA VIRUS
JC VIRUS PML IN HIV PATIENTS
49. Only disease eradicated globally
Last case occurred in Somalia in 1977
WHO declared it on 8 may 1980
April 1977 india was declared small pox free
No known animal reservoir
No long term carrier
Life long immunity after recovery from disease
Highly effective vaccine
Easy detection of cases
50.
51. • SMALL POX
• Centrifugal
• Affects palms & soles
• Axilla is spared
• CHICKEN POX
• Centripetal
• Sparing of palms & soles
• Axilla is affected
52. Chicken pox
Superficial & unilocular
Symmetrical mostly on flexor surface
Pleomorphic
Dew drop on rose petal appearance
Centripetal
Evolution of rash is rapid
small pox
Deep & multiseated
Affect extensor surfaces
Monomorphic
Umbilicated appearance
Centrifugal
Evolution is slow
53.
54.
55.
56. Varicella zoster (herpes zoster type III)
IP 10 – 21 days
Spreads from Respiratory via air droplets or rarely from conjunctiva
IP of chicken pox is 2 days prior to 5 days after onset of rash
SAR of 90 %
57.
58. Tzanck smear multinucleated giant cells
Cowdry type A intranuclear inclusion
FAMA flurescent Ab to membrane Ag most sensitive
ELISA
PCR for detection of VZV DNA
59. Chicken pox in
immunocompetent
•Symptomatic
•No antiviral
Chicken pox of
<24 hour
•Acyclovir
Herpes zoster
•Valacyclovir
•Famciclovir
Post herpetic
neuralgia
•Analgesics
•Gabapentin
•Lidocaine patch
•amitryptilline
61. Crosses palcenta
More serious if transmitted in first
trimester fetal varicella syndrome
(cicatrising skin lesions)
Limb hypoplasia
Choreoretinitis
Microcephaly
62. VZIG
Given with in 72 hours of exposure
Premature infants
Newborn
If mother develops CP 5 days before delivery – 48 hrs after delivery
Immunosuppression
Pregnancy
Varicella vaccine
Live vaccine (OKA STRAIN)
In children after 1 dose 95 % seroconversion
Above 12 years
Single dose seroconversion 78 %
2 doses @ 4 weeks part 99 %
Use with caution in immunocompromised
Used only when CD4 count > 15 %
VZIG & vaccine cannot be given
together as VZIG binds to vaccine
63.
64. ONLY DNA VIRUS HAVING SINGLE STRANDED DNA
SMALLEST VIRUS
DIFFICULT TO CULTURE VIRUS ISOLATION IS NOT USED TO DETECT
INFECTION
HAS SMALLEST GENOME
SLAPPED CHEEK APPEARANCE
APLASTIC CRISIS IN CHILDREN WITH C/C HEMOLYTIC ANEMIA
ARTHRALGIA & ARTHRITIS IN ADULTS
TRANSPLACENTAL TRANSMISSION IS 30 % OR HIGHER
NONIMMUNE FETAL HYDROPS