1. APPLICATIONS OF SUBLIMATION
1)
The predominant process we apply for purification is well accepted and
commonly known as sublimation under vacuum or gas flow conditions.
In addition we operate systems for zone refinement, vacuum drying and
further customized systems which can be adapted to customer
requirements.
Our proprietary process via sublimation uses several individual
purification steps, which have to be controlled precisely. In combination
they guarantee for high quality and efficiency.
2)
Pharmaceutical cocrystals open a new avenue to address the problems
of poorly soluble drugs. They contain two or more distinct molecules
arranged to create a new crystal form whose properties are often
superior to those of each of the separate entities. The pharmaceutical
cocrystals are formed between a molecular or ionic drug and a cocrystal
former that is a solid under ambient conditions .These are prepared by
slow evaporation from a drug solution containing stoichiometric
amounts of the components (cocrystal formers); however, sublimation,
growth from the melt, or grinding of two or more solid cocrystal formers
in a ball mill are also suitable methodologies.
3)
Preparation of highly porous gastroretentive metformin tablets using a
sublimation method. The present investigation is aimed to formulate
floating gastroretentive tablets containing metformin using a
sublimation material, Camphor was used as the sublimation material to
prepare GR tablets that are low-density and easily floatable.

2. 4)
Sublimation process also allows you to use infinite colors and smooth
gradients and shadow effects. Since sublimated inks are fused directly
with the fabric, the jersey will perform as well and feel as smooth as a
blank jersey, no matter what designs you sublimate across the fabric.
5)
Sublimation is also used to create freeze-dried substances, for example
tea, soup or drugs in a process called lypholization, which consists of
freezing a solution or suspension and heating it very slowly under
medium to high vaccum specifically, a pressure lower than the vapour
pressure of the solvent at its melting point. This can be well below the
melting point of water if there are organic solvents or salts in the sample
being freeze-dried. The resulting solid is usually much easier to dissolve
or resuspend than one that is produced from a liquid system, and the
low temperatures involved cause less damage to sensitive or reactive
substances.

3. APPLICATONS OF DESSICATION
1) Microcrystalline (MCC) pellets of different structural and mechanical
properties were produced by the process of extrusion and spheronization
by using different drying techniques, in which desiccation with silica-gel is
also included.
2) Dessication is also used to separate a volatile liquid from a less volatile
liquid. Granulation, desiccation, exsication all three used to separate a
volatile liquid from a solid.
3) Spray drying is one of the methods of dessication by which solutions and
slurries are dried.
4) In biology and ecology, desiccation refers to the drying out of a living
organism, such as when aquatic animals are taken out of water, or when
plants are exposed to sunlight or drought. Ecologists frequently study and
assess various organisms' susceptibility to desiccation.
5) In the process of whitening the to0thpaste mass loss is done by dessication.
It was observed that when toothpastes were weight on a petry dish and
heated in an oven at 105 ‘C for 24 hours. They were then weight again and
again. Loss by dessication was calculated from the difference between the
initial and final weights.

4. REFERENCES:www.creaphys.com/Technology.html
http://www.ncbi.nlm.nih.gov/pubmed/23246798
http://www.newworldencyclopedia.org/entry/Sublimation_%28chemistry%29#Uses
http://www.wasanlab.com/pharm/glossary.html
http://www.scribd.com/doc/33000088/Miscellaneous-Physical-Pharmacy-Processes