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Chapter 10
Presentation
Scott Overly
Bio 120
Gestation
 Length of time from conception to birth,
  generally nine months. Calculated from
  the first day of the last menstrual period,
  with a range of 259 to 280 days.
 Premature is considered being born
  before completing 37 weeks of gestation
Embryo
 The time the fertilized egg emplants in the
  uterus til the end of the eighth week
 Organ systems of the body are formed
Fetus
 Stage after embryo
 Lasts until birth
 Longest period of gestation
 Organs mature and start to function
1st Trimester
   physical changes may include breast
    tenderness, fatigue and nausea. Emotions may
    range from excitement to anxiety. For your baby,
    the first trimester is a time of rapid growth and
    development. Your baby's brain, spinal cord and
    other organs begin to form, and your baby's
    heart begins to beat. Your baby's fingers and
    toes even begin to take shape.
2nd Trimester
 During the second trimester of pregnancy
  — from months four to six
 Second trimester signs and symptoms
  may include larger breasts, a growing
  belly and skin changes.
 Baby, the second trimester often marks
  the ability to kick, make facial expressions
  and hear.
3rd Trimester
   Third trimester signs and symptoms may include
    backaches, swollen ankles and mounting anxiety.
   During the third trimester, the baby will likely open his or
    her eyes and gain weight. This rapid growth may lead to
    more pronounced fetal movements. By the end of week
    37, your baby is considered full term.
   During the third trimester, you'll continue to meet with
    your health care provider regularly. He or she may check
    the baby's position and assess cervical changes.
Uterus
   It is placed between the bladder and the rectum.
    One end of the uterus opens into the vagina and
    is known as the cervix. The other end is
    connected to the fallopian tubes. The pelvic
    diaphragm, urogenital diaphragm and the
    perineal body primarily support the uterus. The
    ligaments and peritoneum also support it.
   The organ in which the developing fetus resides.
Function
   Once the egg is fertilized it will come to rest in
    the uterus. The lining of the uterus, the
    endometrium, will have prepared itself to receive
    the embryo and will then house the fetus for the
    next nine months.

   The main purpose of the uterus is to nourish the
    developing fetus in the months leading up to
    birth.
Layers – Endometrium
 Innermost lining of the uterine cavity.
  Damage to the endometrium can result in
  adhesions or fibrosis. The endometrium is
  the lining that is shed during menstruation
  if no pregnancy has occurred.
 Reacts to hormonal changes which
  prepares it to receive fertilized ovum
 Provides rich blood supply
Layers - Myometrium
 This is the largest layer of the uterus. The
  innermost point of the myometrium is
  called the junctional zone.
 Thick muscular wall that provides
  contractions which push the baby out of
  the birth canal during delivery
Layers - Parametrium
   The loose tissue that surrounds the uterus
    is called the parametrium. The
    parametrium is where the uterine artery
    and the ovarian ligament are situated.
Layers - Perimetrium
   Perimetrium, or peritoneum is the serous
    membrane that covers the outer most
    layer of the uterus. This layer supports the
    abdominal organs and serves as a
    channel for their lymph and blood nerves
    and vessels
Menopause
 Cessation or ending of menstrual activity.
 Generally between ages 40-55
Symptoms
   Technically, you don't actually "hit" menopause
    until it's been one year since your final menstrual
    period. In the United States, that happens at
    about age 51, on average.
   But in the months or years leading up to that
    point, you might experience these signs and
    symptoms:
   Irregular periods
   Decreased fertility
   Vaginal dryness
Symptoms
 Hot flashes
 Sleep disturbances
 Mood swings
 Increased abdominal fat
 Thinning hair
 Loss of breast fullness
Causes
   Natural decline of reproductive hormones. As you
    approach your late 30s, your ovaries start making less
    estrogen and progesterone. Fewer potential eggs are
    ripening in your ovaries each month, and ovulation is
    less predictable. Post-ovulation surge in progesterone
    becomes less dramatic. Your fertility declines, partially
    due to these hormonal effects.
   These changes become more pronounced in your 40s.
    Your menstrual periods may become longer or shorter,
    heavier or lighter, and more or less frequent until your
    ovaries stop producing eggs, and you have no more
    periods.
Causes
   Hysterectomy. A hysterectomy that removes your
    uterus, but not your ovaries, usually doesn't cause
    menopause. Although you no longer have periods, your
    ovaries still release eggs and produce estrogen and
    progesterone. But an operation that removes both your
    uterus and your ovaries (total hysterectomy and bilateral
    oophorectomy) does cause menopause, without any
    transitional phase. Periods stop immediately, and you're
    likely to have hot flashes and other menopausal signs
    and symptoms.
Causes
   Chemotherapy and radiation therapy.
    These cancer therapies can induce
    menopause, causing symptoms such as
    hot flashes during the course of treatment
    or within three to six months
Causes
Primary ovarian insufficiency.
 Approximately 1 percent of women
 experience menopause before age 40.
 Menopause may result from primary
 ovarian insufficiency stemming from
 genetic factors or autoimmune disease,
 but often no cause for primary ovarian
 insufficiency can be found.
Testing
   Under certain circumstances, your doctor may
    check your level of follicle-stimulating hormone
    (FSH) and estrogen (estradiol) with a blood test.
    As menopause occurs, FSH levels increase and
    estradiol levels decrease.
   A blood test to determine your level of thyroid-
    stimulating hormone, because hypothyroidism
    can cause symptoms similar to those of
    menopause.
Treatments
   Hormone therapy. Estrogen therapy remains the most effective
    treatment option for relieving menopausal hot flashes. Depending
    on personal and family medical history, the doctor may recommend
    estrogen in the lowest dose needed to provide symptom relief for
    you.
   Low-dose antidepressants. Venlafaxine (Effexor), an
    antidepressant decreases menopausal hot flashes. Other SSRIs
    can be helpful, including fluoxetine (Prozac, Sarafem), paroxetine
    (Paxil, others), citalopram (Celexa) and sertraline (Zoloft).
   Gabapentin (Neurontin). This drug is approved to treat seizures,
    but it also has been shown to significantly reduce hot flashes.
   Clonidine (Catapres, others). Clonidine, a pill or patch typically
    used to treat high blood pressure, may significantly reduce the
    frequency of hot flashes, but unpleasant side effects are common.
Treatments
   Bisphosphonates. Nonhormonal medications, which include
    alendronate (Fosamax), risedronate (Actonel) and ibandronate
    (Boniva), to prevent or treat osteoporosis. These medications
    effectively reduce both bone loss and your risk of fractures and have
    replaced estrogen as the main treatment for osteoporosis in women.
   Selective estrogen receptor modulators (SERMs). SERMs are a
    group of drugs that includes raloxifene (Evista). Raloxifene mimics
    estrogen's beneficial effects on bone density in postmenopausal
    women, without some of the risks associated with estrogen.
   Vaginal estrogen. To relieve vaginal dryness, estrogen can be
    administered directly to the vagina using a vaginal tablet, ring or
    cream. This treatment releases just a small amount of estrogen,
    which is absorbed by the vaginal tissue. It can help relieve vaginal
    dryness, discomfort with intercourse and some urinary symptoms

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Chapter 10 presentation

  • 2. Gestation  Length of time from conception to birth, generally nine months. Calculated from the first day of the last menstrual period, with a range of 259 to 280 days.  Premature is considered being born before completing 37 weeks of gestation
  • 3. Embryo  The time the fertilized egg emplants in the uterus til the end of the eighth week  Organ systems of the body are formed
  • 4. Fetus  Stage after embryo  Lasts until birth  Longest period of gestation  Organs mature and start to function
  • 5. 1st Trimester  physical changes may include breast tenderness, fatigue and nausea. Emotions may range from excitement to anxiety. For your baby, the first trimester is a time of rapid growth and development. Your baby's brain, spinal cord and other organs begin to form, and your baby's heart begins to beat. Your baby's fingers and toes even begin to take shape.
  • 6. 2nd Trimester  During the second trimester of pregnancy — from months four to six  Second trimester signs and symptoms may include larger breasts, a growing belly and skin changes.  Baby, the second trimester often marks the ability to kick, make facial expressions and hear.
  • 7. 3rd Trimester  Third trimester signs and symptoms may include backaches, swollen ankles and mounting anxiety.  During the third trimester, the baby will likely open his or her eyes and gain weight. This rapid growth may lead to more pronounced fetal movements. By the end of week 37, your baby is considered full term.  During the third trimester, you'll continue to meet with your health care provider regularly. He or she may check the baby's position and assess cervical changes.
  • 8. Uterus  It is placed between the bladder and the rectum. One end of the uterus opens into the vagina and is known as the cervix. The other end is connected to the fallopian tubes. The pelvic diaphragm, urogenital diaphragm and the perineal body primarily support the uterus. The ligaments and peritoneum also support it.  The organ in which the developing fetus resides.
  • 9. Function  Once the egg is fertilized it will come to rest in the uterus. The lining of the uterus, the endometrium, will have prepared itself to receive the embryo and will then house the fetus for the next nine months.  The main purpose of the uterus is to nourish the developing fetus in the months leading up to birth.
  • 10. Layers – Endometrium  Innermost lining of the uterine cavity. Damage to the endometrium can result in adhesions or fibrosis. The endometrium is the lining that is shed during menstruation if no pregnancy has occurred.  Reacts to hormonal changes which prepares it to receive fertilized ovum  Provides rich blood supply
  • 11. Layers - Myometrium  This is the largest layer of the uterus. The innermost point of the myometrium is called the junctional zone.  Thick muscular wall that provides contractions which push the baby out of the birth canal during delivery
  • 12. Layers - Parametrium  The loose tissue that surrounds the uterus is called the parametrium. The parametrium is where the uterine artery and the ovarian ligament are situated.
  • 13. Layers - Perimetrium  Perimetrium, or peritoneum is the serous membrane that covers the outer most layer of the uterus. This layer supports the abdominal organs and serves as a channel for their lymph and blood nerves and vessels
  • 14. Menopause  Cessation or ending of menstrual activity.  Generally between ages 40-55
  • 15. Symptoms  Technically, you don't actually "hit" menopause until it's been one year since your final menstrual period. In the United States, that happens at about age 51, on average.  But in the months or years leading up to that point, you might experience these signs and symptoms:  Irregular periods  Decreased fertility  Vaginal dryness
  • 16. Symptoms  Hot flashes  Sleep disturbances  Mood swings  Increased abdominal fat  Thinning hair  Loss of breast fullness
  • 17. Causes  Natural decline of reproductive hormones. As you approach your late 30s, your ovaries start making less estrogen and progesterone. Fewer potential eggs are ripening in your ovaries each month, and ovulation is less predictable. Post-ovulation surge in progesterone becomes less dramatic. Your fertility declines, partially due to these hormonal effects.  These changes become more pronounced in your 40s. Your menstrual periods may become longer or shorter, heavier or lighter, and more or less frequent until your ovaries stop producing eggs, and you have no more periods.
  • 18. Causes  Hysterectomy. A hysterectomy that removes your uterus, but not your ovaries, usually doesn't cause menopause. Although you no longer have periods, your ovaries still release eggs and produce estrogen and progesterone. But an operation that removes both your uterus and your ovaries (total hysterectomy and bilateral oophorectomy) does cause menopause, without any transitional phase. Periods stop immediately, and you're likely to have hot flashes and other menopausal signs and symptoms.
  • 19. Causes  Chemotherapy and radiation therapy. These cancer therapies can induce menopause, causing symptoms such as hot flashes during the course of treatment or within three to six months
  • 20. Causes Primary ovarian insufficiency. Approximately 1 percent of women experience menopause before age 40. Menopause may result from primary ovarian insufficiency stemming from genetic factors or autoimmune disease, but often no cause for primary ovarian insufficiency can be found.
  • 21. Testing  Under certain circumstances, your doctor may check your level of follicle-stimulating hormone (FSH) and estrogen (estradiol) with a blood test. As menopause occurs, FSH levels increase and estradiol levels decrease.  A blood test to determine your level of thyroid- stimulating hormone, because hypothyroidism can cause symptoms similar to those of menopause.
  • 22. Treatments  Hormone therapy. Estrogen therapy remains the most effective treatment option for relieving menopausal hot flashes. Depending on personal and family medical history, the doctor may recommend estrogen in the lowest dose needed to provide symptom relief for you.  Low-dose antidepressants. Venlafaxine (Effexor), an antidepressant decreases menopausal hot flashes. Other SSRIs can be helpful, including fluoxetine (Prozac, Sarafem), paroxetine (Paxil, others), citalopram (Celexa) and sertraline (Zoloft).  Gabapentin (Neurontin). This drug is approved to treat seizures, but it also has been shown to significantly reduce hot flashes.  Clonidine (Catapres, others). Clonidine, a pill or patch typically used to treat high blood pressure, may significantly reduce the frequency of hot flashes, but unpleasant side effects are common.
  • 23. Treatments  Bisphosphonates. Nonhormonal medications, which include alendronate (Fosamax), risedronate (Actonel) and ibandronate (Boniva), to prevent or treat osteoporosis. These medications effectively reduce both bone loss and your risk of fractures and have replaced estrogen as the main treatment for osteoporosis in women.  Selective estrogen receptor modulators (SERMs). SERMs are a group of drugs that includes raloxifene (Evista). Raloxifene mimics estrogen's beneficial effects on bone density in postmenopausal women, without some of the risks associated with estrogen.  Vaginal estrogen. To relieve vaginal dryness, estrogen can be administered directly to the vagina using a vaginal tablet, ring or cream. This treatment releases just a small amount of estrogen, which is absorbed by the vaginal tissue. It can help relieve vaginal dryness, discomfort with intercourse and some urinary symptoms