The 16th Annual Meeting of Infantile Seizure Society (ISS) to be held in Cappadocia/ Turkey, on June 23 – 27, 2014 Pub No: PP-002 Session Name: Etipathogenesis 1 Moderators: Tatsuharu Sato, Ercan Demir Date: 24 June 2014 Time: 16:00 - 17:00 Hall: Poster Area

1. Serum and CSF biomarkers in acute
pediatric neurological disorders
Aim
To validate serum and
cerebrospinal fluid (CSF)
biomarkers for diagnosis
and prognosis
estimations.
Conclusions
Both CSF and serum tTau levels could be useful, but mediocre at
best. Further studies are clearly needed to find better biomarkes
or other way around.
(^o^) This paper is published in Brain Dev. 2014;36:489-95.
E-mail: shiihara-ind@umin.net
Methods
Serum CSF S100B, neuron-specific enolase (NSE), and total tau
(tTau) were measured in various acute pediatric neurological
disorders. Their usefulness was validated using receiver operating
characteristic (ROC) curves and area under the curve (AUC)
analysis.
Takashi Shiihara
1
, Taeko Miyake
2
, Sakiko Izumi
2
, Susumu Sugihara
1
, Mio Watanabe
1
,
Jun Ichi Takanashi
3
, Masaya Kubota
4
, Mitsuhiro Kato
5
1
Department of Neurology, Gunma Children's Medical Center, Shibukawa, Gunma, Japan;
2
Department of Laboratory Medicine, Gunma
Children's Medical Center, Shibukawa, Gunma, Japan;
3
Department of Pediatrics, Kameda Medical Center, Kamogawa, Chiba, Japan;
4
Division of Neurology, National Center for Child Health and Development, Setagaya, Tokyo, Japan;
5
Department of Pediatrics, Yamagata
University Faculty of Medicine, Yamagata, Yamagata, Japan
Fig. 1: Biomarkers with various disorders Fig. 2: Biomarkers with good/poor prognosis
Fig. 3: ROC curves analyses
Results
A total of 336 serum and 200 CSF specimens from 313 patients were examined, and we identified
statistically significant differences. CSF and serum tTau levels could be good predictors for
diagnosis (CSF tTau; AUC = 0.76) and prognosis (serum tTau; AUC = 0.78). Diagnostic
categories were as follows; acute encephalitis/encephalopathy (AEE), aseptic meningitis (AM),
afebrile seizures (AS), controls (CTR), febrile seizures (FS), and septic meningitis (SM).