1. 2013. 5. 31
3조 발표자 : 36번 송혜민
Short Term Clinical Efficacy of New
meridol HALITOSIS tooth & tongue gel in
Combination with a Tongue Cleaner to
Reduce Oral Malodor
D. Wilhelm, A.Himmelmann, C.Krause
proDERM Institute for Applied Dermatological
Research GmbH Schenefeld, Germany

2. • 87% 환자가 충치로 인해 구취를 겪고 있으며, 51%는 tongue coating, 17%는
치은염, 15%는 치주염, 17%는 여러 복합요인이 있다.
• 특히 혀의 뒷부분은 해부학적 구조에 의해 혐기성 세균의 서식처이다.
• 혀의 배면에는 여러 종류의 papillae가 있고, filliform papillae는 구취의 주요 요
인이다.
•Tongue cleaner와 tooth and tongue gel을 이용하여, 구취를 줄일 수 있는지를
gas chromatograph measure of VSCs를 이용하여 측정해 보았다.
Introduction

3. • Study Design and Population
1. single-center에서 (independent dermatological research
institute), examiner-blind, randomized, crossover superior design clinical study
가 a seven-day wash-in and a seven-day wash-out period between treatments.
2. 총 54 명의 구취 유발 구강 내 박테리아를 가진(organoleptic rating of 2
2, H2S [hydrogen sulphide] readings > 50 ppb, and CH3SH [methyl mercaptan]
readings > 50 ppb) 비흡연 피실험자들(44 women, 10 men; average age 47.7
years)로 구성. 44명의 피실험자들을 분석.
3. Treatment A: no treatment (control)
Treatment B: mechanical tongue cleaning with tongue cleaner
Treatment C: meridol HALITOSIS tooth & tongue gel applied on tongue
cleaner
Materials and Methods

4. • Wash-in and Wash-out Period
• 최상의 구강 분석하기 위해서 baseline 측정을 위해 최소 일주일전에 피실험자들은 감
독관의 지시를 받음.
• 피실험자들은 standard fluoride toothpaste (1400 ppm F from sodium
monofluorophosphate)와 toothbrush를 받고 감독관들에게 일주일동안 하루에 두번 그
리고 treatment 중간에 잇솔질을 하도록 지시받음.
Materials and Methods
• Test Materials
. meridol HALITOSIS tooth & tongue gel: 1400 ppm F
from amine fluoride/stannous fluoride (ASF), 0.57o zinc
lactate, oral malodor counter actives
. meridol HALITOSIS tonsue cleaner

5. • Application Mode
Materials and Methods

6. • Organoleptic Ratings (Ors)
0 = Odor cannot be detected
1 = Questionable malodor, barely detectable
2 = Slight malodor, exceeds the threshold of malodor
recognition
3 = Moderate malodor, that is definitely detected
4 = Strong malodor
5 = Very strong malodor
Materials and Methods
• VSC Measurements Using a Gas Chromatograph

7. Materials and Methods
• VSC Measurements Using a Gas Chromatograph
Objective measurement
Detects VSC with appropriate
monitor; unable
to differentiate individual
sulphur compounds
Higher affinity to hydrogen
sulphide than dimethyl
sulphide
Simple to perform but fails to
detect oral malodour caused
by non-sulphide components

8. • Organoleptic Evaluation
Results

9. • VSC Concentrations
Results

10. • 구취제거에는 기계적인 tongue cleansing은 비효율적이다.
• 기계적인 tongue cleansing은 단기간의 구취제거에는 효과가 있음을 이전 연
구들은 보여왔지만,
• 이 연구결과는 meridol HALITOSIS tooth & tongue gel이 장기간의 구취제거에 효과적
임을 보여주고 있다.
• 혀 후방 cleansing이 구취제거뿐 아니라 구강 위생을 위해 중요함을 알아야 한다.
Discussion

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