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Testosterone & Antitestoterones(7)
- 1. MALE SEX HORMONES: BY DR.UMA KADAM M.B.B.S. MD ASSOCIATE PROFESSOR PHARMACOLOGY SKNMC DR.UMA K.
- 4. DR.UMA K. Estriol Estrone Cholesterol Pregnenolone Progesterone 17- α - Hydroxy pregnenolone 17- Hydroxy progesterone Dehydro-epi androsterone Andro-stenedione TESTOSTERONE ESTRADIOL Aromatase Aromatase Corticosteroids Corticosteroids DHT 5 -reductase
- 6. DR.UMA K. Testes Leydig Cells Sertoli Cells Negative feedback Estradiol Inhibin Negative feedback FSH Negative feedback Testosterone LH LH & FSH HYPOTHALAMUS ENDOCRINE FACTORS Pituitary GnRH Regulation of secretion
- 10. DR.UMA K. MECHANISM OF ACTION: T DHT DHT- R T- R R R T- R Nucleus 90% 10% 5- -reductase Cytoplasm
- 18. DR.UMA K. Anabolic Steroids Drug Anabolic Androgenic ratio Preparation & Dose Methandienone 3:1 5 – 15 mg/day, p.o. Nandrolone phenylpropionate 3:1 10 – 50 mg/wk, i.m. Nandrolone decanoate 3:1 25 – 50 mg/3 wk, i.m. Stanozolol 3:1 2 - 6 mg/day, p.o. Ethyloestrenol 3:1 8 - 16 mg/day, p.o. Oxandrolone 3:1 5 – 10 mg/day, p.o. Fluoxymesterone 3:1 5 – 10 mg/day, p.o.
- 26. DR.UMA K. Parasympathetic Sympathetic Acetylcholine Noradrenaline Hypothalamus ANS Muscarinic Receptors vasoconstriction Penile flaccidity Penile erection
- 27. DR.UMA K. Penile Erection Vasodilatation Muscarinic Receptors Ca ++ ↑ NO GTP cGMP cAMP ATP ↑ VP AC GC 5’ GMP PDE V SILDENAFIL