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Drug bulletins and other
activities for improving clinical
practice

      Dr Peter R Mansfield OAM BMBS
      peter.mansfield@adelaide.edu.au
The place of bulletins
•
    Important considerations
•
    Methods for improving clinical practice
•
    We can learn from drug promotion
•
Thank you
• Major sponsors:
  – IQWiG [German Institute for Quality and
    Efficiency in Health Care]
  – SSMI [Swiss Society of Internal Medicine]
• Juan Gervas and “nogracias”
• Audience




                                                3
The place of bulletins
The house


            • Roof (Implementation
              eg educational visiting)
            • Walls (Evidence in
              context eg bulletins,
              guidelines)
            • Foundations (Evidence
              eg RCTs, systematic
              reviews, qualitative
              studies)
6
Important considerations
Education or promotion?
• Education = giving knowledge and/or skills to
  enable people to decide for themselves what
  to do.
• Promotion = persuading people to do
  something you want them to do.
• Both can be unethical.
Reactance
 Reactance is an emotional reaction against
 threats to freedom or pressure to change.
 Reactance can cause people to adopt or
 strengthen views contrary to what was
 intended.
Limited time and resources
• If you ask doctors to do more of x, either they
  don’t or they do less of something else. You
  may do more harm than good.
• If asking doctors to less of y, they may replace
  it with something worse.
• Best to ask them to do more of x and less of y.
Are the methods effective?
• Results are mixed so too early for conclusions.
• Will not be effective if not done properly eg
  poorly written educational materials.
    Grimshaw J, Eccles M, Thomas R, MacLennan G, Ramsay C, Fraser C, Vale
•
    L. Toward evidence-based quality improvement. Evidence (and its
    limitations) of the effectiveness of guideline dissemination and
    implementation strategies 1966-1998. J Gen Intern Med. 2006 Feb;21
    Suppl 2:S14-20.
    Lu CY, Ross-Degnan D, Soumerai SB, Pearson SA. Interventions designed to
•
    improve the quality and efficiency of medication use in managed care: a
    critical review of the literature - 2001-2007. BMC Health Serv Res. 2008
    Apr 7;8:75.
Methods for improving clinical
practice
• EPOC (Cochrane-Effective Practice and
  Organisation of Care) Classification of
  Professional Interventions
  Grimshaw J, Eccles M, Thomas R, MacLennan G, Ramsay C, Fraser C, Vale
  L. Toward evidence-based quality improvement. Evidence (and its
  limitations) of the effectiveness of guideline dissemination and
  implementation strategies 1966-1998. J Gen Intern Med. 2006 Feb;21
  Suppl 2:S14-20.
Educational materials
• = distribution of published or printed
  recommendations for clinical care, including
  clinical practice guidelines, audio-visual
  materials, and electronic publications.
• Often not effective, but cheap and …
• Can be effective when well written, + doctors
  believe they have a problem + the materials
  quickly provide an easy solution.
Educational meetings
• = health care providers who have participated
  in conferences, lectures, workshops, or
  traineeships.
• Can be effective when interactive or
  enjoyable.
Promotional meetings
Orlowski JP, Wateska L. The effects of pharmaceutical firm enticements on physician prescribing
patterns: there’s no such thing as a free lunch. Chest 1992;102:270-3.




                                                                                              15
Local consensus processes
• = inclusion of participating providers in
  discussion to ensure that they agreed that the
  chosen clinical problem was important and
  the approach to managing the problem was
  appropriate.
• Message may be improved or worsened so
  may lead to better or worse practice.
Educational outreach visits
• = use of a trained person who met with
  providers in their practice settings to give
  information with the intent of changing the
  provider’s practice.
• Can be very effective because message can be
  individualised.
• Expensive but cost effective sometimes.
Cristin Duren, Drug Rep




 Saul S. Gimme an Rx! Cheerleaders Pep Up Drug Sales. New York Times.
 November 28, 2005                                                    18
Local opinion leaders
• = use of providers nominated by their
  colleagues as ‘‘educationally influential.’’
• Can be effective but influence networks are
  unstable.
Expert Opinion Leaders (OL)




                              20
Patient mediated interventions
• = new clinical information (not previously
  available) collected directly from patients and
  given to the provider, e.g., depression scores
  from an instrument.
• Taps doctor’s desire to please the patient.
• The patient’s request can create the time to
  do the work.
Audit and feedback
• = any summary of clinical performance of
  health care over a specified period of time.
• Some times done with comparison with peers.
• Peer comparisons can be a powerful influence
  but can mislead.
Reminders
• = patient or encounter-specific information,
  provided verbally, on paper or on a computer
  screen that is intended to prompt a health
  professional to recall information
• Can be effective if doctor is already convinced
  that recommendation is sound and doctor is
  not overloaded.
Marketing
• = use of personal interviewing, group
  discussion, or a survey of targeted providers
  to identify barriers to change and subsequent
  design of an intervention that addresses
  identified barriers.
• Can be very effective if done well.
• The barriers that people mention may not be
  the real barriers.
  Checkland K, Harrison S, Marshall M. Is the metaphor of ‘barriers to
  change’ useful in understanding implementation? Evidence from general
  medical practice. J Health Serv Res Pol 2007;12(2):95–100
25
Mass media
• = varied use of communication that reached
  great numbers of people including television,
  radio, newspapers, posters, leaflets, and
  booklets, alone or in conjunction with other
  interventions; and targeted at the population
  level.
• Taps doctor’s desire to please the patient.
• The patient’s request can create the time to
  do the work.
We can learn from drug promotion
Promotion is a mirror to our souls
              “Now can you think what the
              Mirror of Erised shows us all?’…
              Harry thought. Then he said
              slowly, ‘It shows us what we
              want … whatever we want …’
              ‘Yes and no,’ said Dumbledore
              quietly. It shows us nothing
              more or less than the deepest,
              most desperate desire of our
              hearts.”
              Mansfield P. Accepting what we can learn from
              advertising's mirror of desire. BMJ. 2004 Dec
              18;329(7480):1487-8.
                                                          28
29
30
31
Being human has many advantages

    Compassion
•
    Intuition
•
    Humor
•
    Imagination
•




                              32
Doctors are human
“Medical men are subject to the same kinds of
stress, the same emotional influences as effect
laymen.
Physicians have, as part of their self image, a
determined feeling that they are rational and
logical, particularly in their choice of
pharmaceuticals.
The advertiser must appeal to this rational image,
and at the same time make a deeper appeal to the
emotional factors which really influence sales.”
Smith MC. Principles of pharmaceutical marketing. Philadelphia: Lea & Febiger 1968
                                                                                     33
Motivations
              Burnt out Dodo

              Caring Bunny

              Conservative Sheep

              Entrepreneurial Wolf
                Branthwaite A, Downing T.
                Marketing to doctors – the
                human factor. Scrip Magazine
                1995 March;32-5


                                      34
Context:

Information
Overload

Pressure for quick
decisions




                     35
Decision Shortcuts




                     36
Shortcuts can be:
                    • A quick easy
                      path to the right
                      conclusion
                    • A quick easy
                      path to the
                      wrong
                      conclusion
                    • Difficult to avoid
                      because of lack
                      of time
                                      37
Common shortcuts

    Expert endorsement
•
    Popular with peers
•
    Newer
•
    More expensive
•
39
40
Healthy Skepticism

                Improving health by
                reducing harm from
                misleading drug
                promotion


            www.healthyskepticism.org

                                        41

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Medicamentos Madrid Mansfield1 Effective Activities

  • 1. Drug bulletins and other activities for improving clinical practice Dr Peter R Mansfield OAM BMBS peter.mansfield@adelaide.edu.au
  • 2. The place of bulletins • Important considerations • Methods for improving clinical practice • We can learn from drug promotion •
  • 3. Thank you • Major sponsors: – IQWiG [German Institute for Quality and Efficiency in Health Care] – SSMI [Swiss Society of Internal Medicine] • Juan Gervas and “nogracias” • Audience 3
  • 4. The place of bulletins
  • 5. The house • Roof (Implementation eg educational visiting) • Walls (Evidence in context eg bulletins, guidelines) • Foundations (Evidence eg RCTs, systematic reviews, qualitative studies)
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  • 8. Education or promotion? • Education = giving knowledge and/or skills to enable people to decide for themselves what to do. • Promotion = persuading people to do something you want them to do. • Both can be unethical.
  • 9. Reactance Reactance is an emotional reaction against threats to freedom or pressure to change. Reactance can cause people to adopt or strengthen views contrary to what was intended.
  • 10. Limited time and resources • If you ask doctors to do more of x, either they don’t or they do less of something else. You may do more harm than good. • If asking doctors to less of y, they may replace it with something worse. • Best to ask them to do more of x and less of y.
  • 11. Are the methods effective? • Results are mixed so too early for conclusions. • Will not be effective if not done properly eg poorly written educational materials. Grimshaw J, Eccles M, Thomas R, MacLennan G, Ramsay C, Fraser C, Vale • L. Toward evidence-based quality improvement. Evidence (and its limitations) of the effectiveness of guideline dissemination and implementation strategies 1966-1998. J Gen Intern Med. 2006 Feb;21 Suppl 2:S14-20. Lu CY, Ross-Degnan D, Soumerai SB, Pearson SA. Interventions designed to • improve the quality and efficiency of medication use in managed care: a critical review of the literature - 2001-2007. BMC Health Serv Res. 2008 Apr 7;8:75.
  • 12. Methods for improving clinical practice • EPOC (Cochrane-Effective Practice and Organisation of Care) Classification of Professional Interventions Grimshaw J, Eccles M, Thomas R, MacLennan G, Ramsay C, Fraser C, Vale L. Toward evidence-based quality improvement. Evidence (and its limitations) of the effectiveness of guideline dissemination and implementation strategies 1966-1998. J Gen Intern Med. 2006 Feb;21 Suppl 2:S14-20.
  • 13. Educational materials • = distribution of published or printed recommendations for clinical care, including clinical practice guidelines, audio-visual materials, and electronic publications. • Often not effective, but cheap and … • Can be effective when well written, + doctors believe they have a problem + the materials quickly provide an easy solution.
  • 14. Educational meetings • = health care providers who have participated in conferences, lectures, workshops, or traineeships. • Can be effective when interactive or enjoyable.
  • 15. Promotional meetings Orlowski JP, Wateska L. The effects of pharmaceutical firm enticements on physician prescribing patterns: there’s no such thing as a free lunch. Chest 1992;102:270-3. 15
  • 16. Local consensus processes • = inclusion of participating providers in discussion to ensure that they agreed that the chosen clinical problem was important and the approach to managing the problem was appropriate. • Message may be improved or worsened so may lead to better or worse practice.
  • 17. Educational outreach visits • = use of a trained person who met with providers in their practice settings to give information with the intent of changing the provider’s practice. • Can be very effective because message can be individualised. • Expensive but cost effective sometimes.
  • 18. Cristin Duren, Drug Rep Saul S. Gimme an Rx! Cheerleaders Pep Up Drug Sales. New York Times. November 28, 2005 18
  • 19. Local opinion leaders • = use of providers nominated by their colleagues as ‘‘educationally influential.’’ • Can be effective but influence networks are unstable.
  • 21. Patient mediated interventions • = new clinical information (not previously available) collected directly from patients and given to the provider, e.g., depression scores from an instrument. • Taps doctor’s desire to please the patient. • The patient’s request can create the time to do the work.
  • 22. Audit and feedback • = any summary of clinical performance of health care over a specified period of time. • Some times done with comparison with peers. • Peer comparisons can be a powerful influence but can mislead.
  • 23. Reminders • = patient or encounter-specific information, provided verbally, on paper or on a computer screen that is intended to prompt a health professional to recall information • Can be effective if doctor is already convinced that recommendation is sound and doctor is not overloaded.
  • 24. Marketing • = use of personal interviewing, group discussion, or a survey of targeted providers to identify barriers to change and subsequent design of an intervention that addresses identified barriers. • Can be very effective if done well. • The barriers that people mention may not be the real barriers. Checkland K, Harrison S, Marshall M. Is the metaphor of ‘barriers to change’ useful in understanding implementation? Evidence from general medical practice. J Health Serv Res Pol 2007;12(2):95–100
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  • 26. Mass media • = varied use of communication that reached great numbers of people including television, radio, newspapers, posters, leaflets, and booklets, alone or in conjunction with other interventions; and targeted at the population level. • Taps doctor’s desire to please the patient. • The patient’s request can create the time to do the work.
  • 27. We can learn from drug promotion
  • 28. Promotion is a mirror to our souls “Now can you think what the Mirror of Erised shows us all?’… Harry thought. Then he said slowly, ‘It shows us what we want … whatever we want …’ ‘Yes and no,’ said Dumbledore quietly. It shows us nothing more or less than the deepest, most desperate desire of our hearts.” Mansfield P. Accepting what we can learn from advertising's mirror of desire. BMJ. 2004 Dec 18;329(7480):1487-8. 28
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  • 32. Being human has many advantages Compassion • Intuition • Humor • Imagination • 32
  • 33. Doctors are human “Medical men are subject to the same kinds of stress, the same emotional influences as effect laymen. Physicians have, as part of their self image, a determined feeling that they are rational and logical, particularly in their choice of pharmaceuticals. The advertiser must appeal to this rational image, and at the same time make a deeper appeal to the emotional factors which really influence sales.” Smith MC. Principles of pharmaceutical marketing. Philadelphia: Lea & Febiger 1968 33
  • 34. Motivations Burnt out Dodo Caring Bunny Conservative Sheep Entrepreneurial Wolf Branthwaite A, Downing T. Marketing to doctors – the human factor. Scrip Magazine 1995 March;32-5 34
  • 37. Shortcuts can be: • A quick easy path to the right conclusion • A quick easy path to the wrong conclusion • Difficult to avoid because of lack of time 37
  • 38. Common shortcuts Expert endorsement • Popular with peers • Newer • More expensive •
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  • 41. Healthy Skepticism Improving health by reducing harm from misleading drug promotion www.healthyskepticism.org 41