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NEUROLOGY

  DR.WALID REDA ASHOUR

  LECTURER OF NEUROLOGY
INTRODUCTION
WHAT IS NEUROLOGY?



Neurology is the branch of medicine that
 deals with diseases of the nervous system.
MAJOR DIVISIONS
           CENTRAL
           NERVOUS
            SYSTEM
NERVOUS
 SYSTEM
          PERIPHERAL
           NERVOUS
            SYSTEM
CENTRAL NERVOUS SYSTEM
Intracranial
   Intracranial      Spinal
                     Spinal
       part
       part           part
                      part




1. Cerebrum       1- Spinal cord
2. Brain stem
                  2- Cauda equina
3. Cerebellum
I- INTRACRANIAL PART
1- CEREBRUM

 Two (2) cerebral hemispheres.
 Connected to:
1. Each other by CORPUS CALLOSUM.
2. Brain stem by CEREBRAL PEDUNCLES.

- Outer gray matter (cerebral cortex) contains certain
    areas with specific functions.
- Inner white matter composed of nerve fibers
    conducting impulses TO & FROM cerebral cortex
EACH cerebral hemisphere divided into :

FOUR ( 4 )
 LOBES:


1. Frontal
2. Parietal
3. Temporal
4. Occipital
2- Brain stem
Formed of :
          1- Midbrain
          2- Pons
           3- Medulla
Connected to:
 1. Cerebral hemisphere
    by cerebral peduncles

2. Cerbellum by cerebellar
   peduncles
BRAIN STEM contains motor nuclei of cranial
nerves:


• 3 & 4 in MIDBRAIN
• 5, 6 &7 in PONS
• 9, 10, 11 & 12 in MEDULLA


N.B. 1, 2 & 8
are sensory nerves have no
motor nuclei
NAMES OF CRANIAL NERVES
• 1 Olfactory
• 2 Optic
• 3 Oculomotor
• 4 Trochlear
• 5 Trigeminal
• 6 Abducent
• 7 Facial
• 8 Vestibulocochlear
• 9 Glossopharyngeal
• 10 Vagus
• 11 Accessory
• 12 Hypoglossal
CLASSIFICATION OF CRANIAL NERVES
•   SENSORY : contain only sensory fibers
     1- Olfactory
     2- Optic
     8- Vestibulocochlear
•   MOTOR : contain only motor fibers
     3- Oculomotor
     4- Trochlear
     6- Abducent
     11- Accessory
     12- Hypoglossal
•   MIXED : contain both sensory and motor fibers
     5- Trigeminal
     7- Facial
     9- Glossopharyngeal
     10- Vagus
Sensory cranial nerves
N.   Name         Function   Assessment
1    Olfactory    Smell      Examination of
                             smell
2    Optic        Vision     Acuity, field &
                             fundus
8    Vestibular   Equilibrium Caloric and
     part                    rotational chair
     Cochlear     Hearing    Watch test,
     part                    Weber test
Motor cranial nerves
N.   Name         Function                       Assessment
3    Oculomotor Motor to superior, inferior and Ptosis, pupil, eye
                medial recti; inferior oblique & movements &
                levator palpebrae superioris     squint

                  Parasympathetic to sphincter
                  papillae and ciliary muscle

4    Trochlear    Motor to superior oblique      Look to opposite
                                                 shoulder
6    Abducent     Motor to lateral rectus        Lateral eye
                                                 movement
11   Accessory    Motor to sternocleidomastoid   Elevaton of
                  and trapezius                  shoulders and
                                                 neck rotation
12   Hypoglossal Motor to muscles of tongue      Tongue
                                                 movements
Mixed cranial nerves
N.   Name               Function                Assessment
5    Trigeminal         Muscles of              Face sensations &
                        mastication &           power of muscles of
                        sensations of face      mastication

7    Facial             Muscles of facial       Muscles of facial
                        expression & taste      expression & taste
                        sensation in ant. 1/3   sensation in ant. 1/3 of
                        of tongue               tongue
10   Vagus              Sensation and           Palatal and pharyngeal
                        movements of            reflexes & movements of
                        Larynx, pharynx,        uvula
                        thoracic and
                        abdominal organs
9    Glossopharyngeal   Taste in post 2/3 of    Taste & general
                        tongue & gen.           sensation and
                        sensation               pharyngeal reflex
3- CEREBELLUM
• Behind the brain stem
• Formed of : * Medline vermis
              * Two cerebellar
  hemispheres

• Composed of :
           Outer grey matter and inner
           white matter
CEREBELLAR PEDUNCLES


                        MB


                    Pons           C




                           MO




  Superior peduncle connects cerebellum with MIDBRAIN.
  Middle peduncle connects cerebellum with PONS.
  Inferior peduncle connects cerebellum with MEDULLA
OBLONGATA
CEREBELLAR HEMISPHERES AND VERMIS

Left                                                   right
Hemisphere                                       hemisphere




                        VERMIS

 Cerebellar Hemispheres are the two bilateral structures.
    Vermis is the unpaired midline structure between
                  the two hemispheres.
II- SPINAL PART
1- SPINAL CORD

• Inside spinal canal
• End at lower border of L1 vertebra.
• Its lowermost 3 segments S3,4,5 = Conus.
• The above 4 segments L4,5 & S1,2 = Epiconus.

• Inner grey matter (cells) surrounded by
 white matter.
SPINAL CORD
SPINAL CORD TRACTS
• White matter contains ascending and
  descending nerve fibers (TRACTS):
1- ASCENDING
• Lateral & Ventral spinothalamic.
• Gracile & Cuneate.
• Spinocerebellar.
• Lissauer’s.

2- DESCENDING
• Corticospinal (pyramidal).
• Reticulospinal, vestibulospinal, tectospinal, rubrospinal &
   olivospinal
2- CAUDA EQUINA

• Collection of LUMBOSACRAL ROOTS which
  fills the lower part of the spinal canal below
  L1 vertebra.
THE   MOTOR   SYSTEM
Motor pathway
UPPER MOTOR NEURON
              (pyramidal system)

* Originates in motor area 4 & premotor area 6
* Terminates at the anterior horn cells (AHCs)
of the different levels of the spinal cord.
* It supplies the opposite side of the body.
LOWER MOTOR NEURON

• Formed of AHCs & Peripheral motor nerves

 (which transmit the motor impulses to the

 voluntry muscles).
EXTRA PYRAMIDAL SYSTEM
• Originates from centers at various levels of CNS
  mainly the BASAL GANGLIA.
• It controls the opposite side of the body.


          CEREBELLAR SYSTEM

• Composed of Neo, Archi & Paleo- cerebellum.
• It co-ordinates the movements of the same side of
  the body.
UMNL                    LMNL
Tone              Increased, with         Decreased
                  ‘clasp knife’ quality
Clonus            Present                 Absent
Fasciculations    Absent                  Present
Muscle Wasting    Absent, but disuse      Present (within 2-3
                  atrophy eventually      weeks)
                  results
Tendon Reflexes   Increased. Extensor Decreased or
                  plantar reflexes.   absent. Flexor
                                      plantar reflexes.
Distribution      Whole limbs, with   Specific muscle
                  more weakness in    groups affected (e.g.
                  the upper limb      in the distribution of
                  extensors and lower a spinal segment, or
                  limb flexors        just the proximal
                                      muscles, etc.)
Thank you

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Neurology Overview

  • 1.
  • 2. NEUROLOGY DR.WALID REDA ASHOUR LECTURER OF NEUROLOGY
  • 4. WHAT IS NEUROLOGY? Neurology is the branch of medicine that deals with diseases of the nervous system.
  • 5. MAJOR DIVISIONS CENTRAL NERVOUS SYSTEM NERVOUS SYSTEM PERIPHERAL NERVOUS SYSTEM
  • 7. Intracranial Intracranial Spinal Spinal part part part part 1. Cerebrum 1- Spinal cord 2. Brain stem 2- Cauda equina 3. Cerebellum
  • 9. 1- CEREBRUM Two (2) cerebral hemispheres. Connected to: 1. Each other by CORPUS CALLOSUM. 2. Brain stem by CEREBRAL PEDUNCLES. - Outer gray matter (cerebral cortex) contains certain areas with specific functions. - Inner white matter composed of nerve fibers conducting impulses TO & FROM cerebral cortex
  • 10. EACH cerebral hemisphere divided into : FOUR ( 4 ) LOBES: 1. Frontal 2. Parietal 3. Temporal 4. Occipital
  • 11. 2- Brain stem Formed of : 1- Midbrain 2- Pons 3- Medulla Connected to: 1. Cerebral hemisphere by cerebral peduncles 2. Cerbellum by cerebellar peduncles
  • 12. BRAIN STEM contains motor nuclei of cranial nerves: • 3 & 4 in MIDBRAIN • 5, 6 &7 in PONS • 9, 10, 11 & 12 in MEDULLA N.B. 1, 2 & 8 are sensory nerves have no motor nuclei
  • 13. NAMES OF CRANIAL NERVES • 1 Olfactory • 2 Optic • 3 Oculomotor • 4 Trochlear • 5 Trigeminal • 6 Abducent • 7 Facial • 8 Vestibulocochlear • 9 Glossopharyngeal • 10 Vagus • 11 Accessory • 12 Hypoglossal
  • 14. CLASSIFICATION OF CRANIAL NERVES • SENSORY : contain only sensory fibers 1- Olfactory 2- Optic 8- Vestibulocochlear • MOTOR : contain only motor fibers 3- Oculomotor 4- Trochlear 6- Abducent 11- Accessory 12- Hypoglossal • MIXED : contain both sensory and motor fibers 5- Trigeminal 7- Facial 9- Glossopharyngeal 10- Vagus
  • 15. Sensory cranial nerves N. Name Function Assessment 1 Olfactory Smell Examination of smell 2 Optic Vision Acuity, field & fundus 8 Vestibular Equilibrium Caloric and part rotational chair Cochlear Hearing Watch test, part Weber test
  • 16. Motor cranial nerves N. Name Function Assessment 3 Oculomotor Motor to superior, inferior and Ptosis, pupil, eye medial recti; inferior oblique & movements & levator palpebrae superioris squint Parasympathetic to sphincter papillae and ciliary muscle 4 Trochlear Motor to superior oblique Look to opposite shoulder 6 Abducent Motor to lateral rectus Lateral eye movement 11 Accessory Motor to sternocleidomastoid Elevaton of and trapezius shoulders and neck rotation 12 Hypoglossal Motor to muscles of tongue Tongue movements
  • 17. Mixed cranial nerves N. Name Function Assessment 5 Trigeminal Muscles of Face sensations & mastication & power of muscles of sensations of face mastication 7 Facial Muscles of facial Muscles of facial expression & taste expression & taste sensation in ant. 1/3 sensation in ant. 1/3 of of tongue tongue 10 Vagus Sensation and Palatal and pharyngeal movements of reflexes & movements of Larynx, pharynx, uvula thoracic and abdominal organs 9 Glossopharyngeal Taste in post 2/3 of Taste & general tongue & gen. sensation and sensation pharyngeal reflex
  • 18. 3- CEREBELLUM • Behind the brain stem • Formed of : * Medline vermis * Two cerebellar hemispheres • Composed of : Outer grey matter and inner white matter
  • 19. CEREBELLAR PEDUNCLES MB Pons C MO  Superior peduncle connects cerebellum with MIDBRAIN.  Middle peduncle connects cerebellum with PONS.  Inferior peduncle connects cerebellum with MEDULLA OBLONGATA
  • 20. CEREBELLAR HEMISPHERES AND VERMIS Left right Hemisphere hemisphere VERMIS Cerebellar Hemispheres are the two bilateral structures. Vermis is the unpaired midline structure between the two hemispheres.
  • 22. 1- SPINAL CORD • Inside spinal canal • End at lower border of L1 vertebra. • Its lowermost 3 segments S3,4,5 = Conus. • The above 4 segments L4,5 & S1,2 = Epiconus. • Inner grey matter (cells) surrounded by white matter.
  • 24. SPINAL CORD TRACTS • White matter contains ascending and descending nerve fibers (TRACTS): 1- ASCENDING • Lateral & Ventral spinothalamic. • Gracile & Cuneate. • Spinocerebellar. • Lissauer’s. 2- DESCENDING • Corticospinal (pyramidal). • Reticulospinal, vestibulospinal, tectospinal, rubrospinal & olivospinal
  • 25. 2- CAUDA EQUINA • Collection of LUMBOSACRAL ROOTS which fills the lower part of the spinal canal below L1 vertebra.
  • 26. THE MOTOR SYSTEM
  • 28. UPPER MOTOR NEURON (pyramidal system) * Originates in motor area 4 & premotor area 6 * Terminates at the anterior horn cells (AHCs) of the different levels of the spinal cord. * It supplies the opposite side of the body.
  • 29. LOWER MOTOR NEURON • Formed of AHCs & Peripheral motor nerves (which transmit the motor impulses to the voluntry muscles).
  • 30. EXTRA PYRAMIDAL SYSTEM • Originates from centers at various levels of CNS mainly the BASAL GANGLIA. • It controls the opposite side of the body. CEREBELLAR SYSTEM • Composed of Neo, Archi & Paleo- cerebellum. • It co-ordinates the movements of the same side of the body.
  • 31. UMNL LMNL Tone Increased, with Decreased ‘clasp knife’ quality Clonus Present Absent Fasciculations Absent Present Muscle Wasting Absent, but disuse Present (within 2-3 atrophy eventually weeks) results Tendon Reflexes Increased. Extensor Decreased or plantar reflexes. absent. Flexor plantar reflexes. Distribution Whole limbs, with Specific muscle more weakness in groups affected (e.g. the upper limb in the distribution of extensors and lower a spinal segment, or limb flexors just the proximal muscles, etc.)
  • 32.