Mahrous Article Summary - 2 - Iron Treatment after Upper Gastrointestinal Bleeding - 2013 Nov.

1. Mahrous Article Summary
Iron Treatment after Upper Gastrointestinal
Bleeding - 2013 Nov.
Waleed Mahrous
Dr Waleed Kh. Mahrous
http://www.ncbi.nlm.nih.gov/pubmed/24251969

2. OBJECTIVES
Dr Waleed Kh. Mahrous
BACKGROUND:
 Nonvariceal acute upper gastrointestinal
bleeding (AUGIB) is often accompanied by
post-discharge anemia.
AIM:
 To investigate whether iron treatment
can effectively treat anemia and to
compare a 3-month regimen of oral iron
treatment with a single administration of
intravenous iron prior to discharge.
Dr Waleed Kh. Mahrous
http://www.nature.com/ajg/journal/v108/n12/full/ajg2013249a.html
http://www.ncbi.nlm.nih.gov/pubmed/24251969

3. METHODS
Dr Waleed Kh. Mahrous
 97 patients with nonvariceal AUGIB and
anemia were enrolled in a doubleblind, placebo-controlled, randomised study.
 The patients were allocated to one of three
groups, receiving a single intravenous
administration of 1000 mg of iron; oral
iron treatment, 200 mg daily for
3 months; or placebo, respectively. The
patients were followed up for 3 months.
Dr Waleed Kh. Mahrous
http://www.nature.com/ajg/journal/v108/n12/full/ajg2013249a.html
http://www.ncbi.nlm.nih.gov/pubmed/24251969

4. RESULTS
 From week 4 onwards, patients receiving treatment
had significantly higher haemoglobin levels
compared with patients who received placebo only.
 At the end of treatment, the proportion of patients
with anemia was significantly higher in the
placebo group (P < 0.01) than in the treatment
groups.
 Intravenous iron appeared to be more effective
than oral iron in ensuring sufficient iron stores.
Dr Waleed Kh. Mahrous
http://www.nature.com/ajg/journal/v108/n12/full/ajg2013249a.html
http://www.ncbi.nlm.nih.gov/pubmed/24251969

5. CONCLUSIONS
 Iron treatment is effective and
essential for treating anemia after
nonvariceal acute upper
gastrointestinal bleeding.
 The route of iron supplementation is less
important in terms of the increase in
haemoglobin levels.
 Iron stores are filled most effectively if
intravenous iron supplementation is
administered .
Dr Waleed Kh. Mahrous
http://www.ncbi.nlm.nih.gov/pubmed/24251969