TA-65 is a proven telomerase activator that was discovered by California biotech company Geron Corporation (NDAQ:GERN) and licensed to TA Sciences. Anti-Aging Labs is licensed to sell TA-65 by T.A. Sciences.
TA-65, anti-aging based on Nobel Prize awarded science. For the first time in mankind's age-old quest, something has the potential to extend maximum human lifespan. Reported benefits: significant improvements in immune system, bone density, sexual performance, skin appearance (elasticity), energy levels (endurance), cardiovascular biomarkers and several other areas.
UNIVERSAL HUMAN VALUES - INTRODUCTION TO VALUE EDUCATION
T.A. Sciences - Oprah
1. “I want LONGER Telomeres”
Oprah Winfrey -November 1st, 2007
Long
Telomeres
Short
Telomeres
2. Telomere Biology:
The Emerging Paradigm Shift
Presentation by:
Noel Thomas Patton
Founder and Chairman
Telomerase Activation Sciences, Inc.
Revised Feb. 3, 2010
3. Telomere Biology:
A Remarkable Breakthrough in Medicine
• 2009 Nobel Prize in medicine awarded for
discovery of telomerase
• Telomeres are the single most important sequences
of DNA because they protect all the other DNA on
our chromosomes
• Short telomeres are associated with almost every
affliction of old age
• Long Telomeres are associated with healthy aging
and longevity
5. Telomere Length vs. Cellular Age
• Somatic Cells generally have little or no telomerase and
telomeres shorten as we get little older
Conception: Our telomeres start out 15,000 base pairs long
By Birth the embryo has divided so many times that
telomere length is down to 10,000 base pairs
Over the rest of our lifetime we lose another 5,000 base
pairs and when they get down to roughly 3-5,000 most of us
will be dead!
6. Bottom Line:
Short Telomeres = the “Kiss of Death”
• People with shorter telomeres in their immune
cells had twice the risk of death from heart failure
as patients with the longest telomeres. From A study
sponsored by the American Heart Association (2008) Farzaneh-Fal et al. “Prognostic Value of
Leukocyte Telomere Length in Patients With Stable Coronary Artery Disease: Data From the Heart and Soul Study.”
Arteriosclerosis, Thrombosis & Vascular Biology. 2008. 28(7):1379-1384.
• 100 year olds in good health had “significantly
longer” telomeres than those with health
problems. Study reported in Journals of Gerontology (2008) Delara et al. “Association
of Longer Telomeres With Better Health in Centenarians.” The Journals of Gerontology Series A: Biological
Sciences and Medical Sciences. 208. 63:809-812.
7. What can be done to keep
telomeres long?
• Lead a healthy lifestyle
• Activate Telomerase
8. What is Telomerase?
• TELOMERASE is an enzyme that confers
longevity to cells
• It does this by lengthening telomeres
• Activating Telomerase will extend the life
of cells beyond the Hayflick Limit
9. Telomerase
Telomere
hTERT
hTR
template
Telomerase is a molecular motor that adds new
DNA onto the ends of telomeres
Slide courtesy of Woody Wright, Ph.D.
10. Telomerase Extends Cell Life Span
and Overcomes the Hayflick Limit
160
140 ] hTERT
+
Cells have Telomerase
120
Population Doublings
100
]
-
80
hTERT
Cells have No Telomerase
60
40
0 50 100 150 200 250 300
Days
Slide courtesy of Woody Wright, Ph.D.
11. Telomerase can be turned on
with a nutraceutical
• 2000: The Corporation discovered TA-65
a single molecule that turns on Telomerase
• 2002: T.A. Sciences exclusively licensed TA-65 from
Geron
• 2007: TA-65 commercialized as a nutraceutical
capsule through licensee doctors
12. How does TA-65 Work?
TA-65 activates telomerase in certain cells
and lengthens telomeres and/or slows their
rate of loss.
This allows cells to live longer in a more
“youthful” state.
13. Schematic of cell rejuvenation using
hTERT:
Gene Expression Comparison:
10,000
genes on
a chip
Young Old Telomerized
(notice overall changes ) (rejuvenated to “Young”)
Actual data in: Funk et al, Exp Cell Res, 2000
14. Is TA-65 the “Fountain of Youth”?
• No, not in the case of a total human being: TA-65
activates telomerase in selected biological systems, not in
every cell of the entire organism
• But, TA-65 users have seen statistically significant
improvements in their immune system, bone density,
sexual performance, and several other key areas
15. Is it the “Holy Grail?”
• Maybe. For the first time in mankind’s age-old quest,
something has the potential to extend maximum human
lifespan
• When cells in a petri dish in the lab have a constant supply
of TA-65, the Hayflick limit is extended and death from
old age is delayed
16. Telomerase can do some pretty
powerful things
Short Telomeres
Gray and Thinning Hair
Weakened Immune System
Intestinal Atrophy
These Mice Reduced Spleen Size
Decreased Wound Healing
are the Decreased Lifespan!
Same Age!
The one on top
has no
telomerase.
Long Telomeres Rudolph, et al Cell 1999
Samper, et al EMBO rep 2001
Slide courtesy of Bill Andrews
17. Skin Reconstitution:
Old Cells Become Young
Human
skin on
a mouse
Young Old Telomerized
Slide courtesy of Bill Andrews
Funk et al, Exp Cell Res, 2000
18. Broad Potential for Tissue System
Regeneration
Immune cells – memory and naïve
Hematopoietic stem cells
Lung alveolar cells
Skin – dermis, epidermis, vasculature
Vascular intima (endothelium)
Osteoblasts, MSCs
GI track epithelial cells
Liver – hepatocytes
Retinal pigmented tissue of eye
Chondrocytes
Skeletal muscle
Kidney – cortex
*Cardiomyocytes
*Neural cells
*No significant bulk telomere loss, but still a protective effect of telomerase activation.
Harley, Current Mol Med., 2005
Garcia, Wright, Shay, Nucl. Acid Res., 2007
Aviv, Hypertension, 2009; Calado, NEJM, 2009
Slide courtesy of Calvin Harley, Ph.D. 2010
19.
20. Who takes TA-65?
• Knowledgeable professionals capable of determining
risk/reward ratios
• About half of our clients are MD’s or PhD’s
• Several are well known Telomere Biologists
Who should take TA-65?
• Anyone over 40 who wants to intervene in age
related decline
• Particularly those who have measured their
Telomeres and found them to be short
21. Telomerase and Cancer:
• The Red Herring: Pre-cancerous cells result from a minimum of 4
specific genetic mutations that cause a loss of growth control.
Because these cells are rapidly dividing, their telomeres soon
become short and they will die. But if a further mutation occurs
that permanently activates telomerase, the cell will become
immortal and fully cancerous.
• This relationship of telomerase to cancer has caused some
biologists to fear telomerase activators. But telomerase is not an
oncogene, it simply is a mechanism to allow cells to live longer.
That is exactly what is required if a person wants to extend their
lifespan. The vast majority of our 10 trillion cells are healthy and
never lose growth control. Obviously to increase lifespan, our
healthy cells have to live longer.
22. Safety
• 5 years of development and safety testing
before introducing TA-65
• Hundreds of clients taking TA-65
• Some for as long as 3 years
• Not a single adverse reaction reported by
our licensed physicians
• Not a single diagnosis of new cancer
• Not a single report of increased cancer load
for clients who already had cancer
24. People currently taking TA-65
have seen the following results*
• Lengthening of the Shortest Telomeres. (These are the ones that
really matter; it only takes one short Telomere out of the 92 in
every cell to send a cell into crisis)
• Improved Immune system: In particular the % and absolute
number of senescent CD8+/28- cells has significantly decreased.
This is a reversal of what normally happens with age
• Improved bone density
• Improved cardiovascular and hormonal biomarkers that normally
show decline with age
• There are also anecdotal results, such as improved energy and
athletic performance, but these effects are not universal and vary
among individuals
*Human trial results substantiating these claims to be published in a peer reviewed scientific journal
25. TA-65
The Only Proven Telomerase Activating Product!
Available through licensed doctors
Thanks to:
Calvin Harley
Bill Andrews
Woody Wright
Maria Blasco
for their contributions to
Telomere Biology and this presentation
Notes de l'éditeur
I am not a scientist or a doctor. I am a businessman. But some of the best scientists in the world such as Dr. Calvin Harley are advising us. I got interested in telomere biology when I turned 50 and started to notice the ugly ravages of age peeking around the corner. I wanted to do something to save my own ass. That was 14 years ago and since then I have personally worked with no salary and invested millions of dollars to bring our telomerase activating product,TA-65 to market. My personal goal is to play a significant role in the battle to “cure aging.”
Let me give some quick definitions:There are 2 basic types of cells in our bodies. GERM cells and SOMATIC cells. GERM cells are our reproductive cells: EGGS and SPERM. Eggs are unusual since they don’t divide after birth, but sperm are continually generated so they have telomerase turned on all the time and their telomeres never get short. In fact, older men have slightly longer telomeres than young men.SOMATIC cells are all the rest of the cells in our body. The telomerase gene in these cells is turned off most of the time and telomeres shorten with age. We can pass on the genes in our germ cells to our children, but when our body (scientifically referred to as the “soma”) dies, all of the genetic material in those cells dies also. It is somatic cells that we are talking about when we talk about normal human aging. Note: Stem cells are specialized somatic cells, they have some telomerase and their telomeres stay longer than ordinarysomatic cells. But they still age, just not as fast. I also want to define “Base Pairs.” Base pairs are units of DNA that make up the chromosomes. That includes the DNA at the tips of our chromosomes that forms telomeres.
Here are a couple examples from the scientific literature:
Do what your doctor says: Eat well, exercise, avoid stress, don’t smoke, and so on.To activate telomerase it is possible to do gene therapy on cells in a lab, but that is not currently possible in live humans; for living people there is only one thing available, our product TA-65.
There is a gene that I will call the telomerase gene, it’s scientific name is hTERT. When that gene is turned on, it causes the enzyme telomerase to be produced. TA-65 is a single small molecule that comes in 25mg capsules. TA-65 transiently turns on the hTERT gene and activates telomerase.
The TA-65 molecule comes from the Astragalus plant that has been in the food chain for over 1,000 years. Because TA-65 is a nutraceutical, it does not need to go through the FDA. We don’t have to wait another decade or more before people can do something about short telomeres.Aging and resulting frailty has been thrust on us by nature without our consent. The resulting decline of vitality and suffering is one of the more tragic aspects of the human condition. I am proud to have an opportunity to do something positive about it.
Gene therapy depicted
The data from current TA-65 users has been evaluated scientifically by Calvin Harley, PhD. and clinically by Joseph Raffaele, M.D.
These graphs show some of the results of a double blind, placebo controlled study we did in 2005. This pivotal study is what prompted us to settle on the specific TA-65 molecule. I should mention that our license from Geron gives us rights to ALL their Telomerase Activators and we could have chosen any other molecule they were working on. TA-65 is in no way a second rate activator.
Who takes: All our clients are informed about Telomere Biology. We do no advertising and make no unsubstantiated claims. Who should take: In general, the shorter one’s telomeres, the more they are likely to benefit from TA-65
2 cancer questions:If a person has cancer, will TA cause the cancer to grow faster? NO. Cancer cells are immortal with the Telomerase gene (TERT) turned on full blast permanently. A transient activator like TA-65 would have absolutely no effect on a fully cancerous cell. You can’t make something immortal more immortal than it already is.Short telomeres cause double strand breaks and end-to--end fusion of chromosomes which in turn cause mutations and cancer. Remember “Short Telomeres are the Kiss of Death.”
Now I want to play a short clip from a presentation made by Dr. Bill Andrews, a noted Telomere Biologist who is the co-discoverer of the telomerase gene.
Thank you Bill. And by the way Bill deserves a special thanks. He was the first 3rd party scientist to recognize the importance of TA-65 and to independently verify that TA-65 actually works as a telomerase activator. And he was the first paying customer to go on TA-65. There is one thing he said that I want to comment on. Bill said that TA-65 only turns on telomerase “a little.” This is exactly what we want to do. In cancer cells, the telomerase gene is turned on full blast and turned on permanently. That makes the cell immortal. TA-65 turns it on transiently; when you stop taking it, the gene shuts off again. We do not immortalize cells and we don’t want to. The earlier slides show conclusive evidence that TA-65 is a telomerase activator and they also show the reasoning behind why we think it is safe. The next slide shows some of the results from our clients who have taken TA-65 for a year or longer.
Notice that TA-65 has a number of significant effects that cross over between different organ systems. This is not surprising because the method of action is universal. In theory a telomerase activator should be beneficial to each and every cell it gets into.