1. Amit Kumar Yadav, PhD
Drug Discovery Research Center (DDRC)
Translational Health Science and Technology
Institute (THSTI)
3rd Nov
2015
2. DISCLAIMER
•This is not a class. Notes aren't helpful,
discussions are !!!
•Most are conceptual analogies, not accurate
details !!!
•Focus is on understanding, not subject
coverage !!!
3. WHAT IS BIO-INFORMATICS ?
WHAT IS COMPUTATIONAL BIOLOGY?
Biology
Chemistry
Mathematics
Computer
Science
Statistics
24. SHOTGUN PROTEOMICS ALGORITHM
Intensity of
matching
peaks
Continuity of
y-ions & b-
ions
Neutral
losses &
Immonium
ions
Fragment
mass error
sensitive
scoring
33. TAKE HOME MESSAGE
• Bioinformatics is NOT biology or informatics, its
both
• Genomics, transcriptomics, proteomics = large
scale studies of biomolecules DNA, RNA and
proteins
• Systems biology = holistic views of biological
phenomenon = mountains of data
• Algorithm development, Automated analysis,
Database development and Data management =
data science