Improving Online Access to Drug Related Information

1. IMPROVING ONLINE ACCESS TO
DRUG-RELATED INFORMATION
JIAO LI, RITU KHARE, ZHIYONG LU
NCBI/NLM
1 2
SEARCH INTEGRATED
ACCESS

2. 1
SEARCH
ASSIGNING BRAND NAMES TO
DRUG MONOGRAPHS
Advil Ibuprofen
Mortin Acetaminophen
Tylenol Editors describe the drug
Consumers use brand information in terms of
names as search keywords active ingredient names
METHODS:
RxNorm Concepts and Relationships
• Ingredient Normalization
• Dosage Form Normalization
Input: Drug Monograph • Obsolescence Ingredient (IN) has_ingredient Brand Name (BN)
Output: Up-to-date Brand names • Reformulation Ibuprofen ingredient_of
Advil
• Veterinary has_tradename tradename_of
Dosage Form (DF) has_dose_form Branded Drug or Package (SBD)
Oral Tablet Advil 100 MG Oral Tablet
dose_form_of [Obsolete=N]
[Veterinary=N]

3. 2 INTEGRATING DRUG-DISEASE
INTEGRATED RELATIONSHIPS FROM MULTIPLE SOURCES
ACCESS
METHODS:
• Filter drug-disease relationships
• Statistics-based filter
• Domain-knowledge based filter
• Rank the disease for each drug
• Ranking function based on
evidence confidence