2. Plastic and Reconstructive Surgery • December 2011
his daughters enjoyed this aspect of having a phy-
sician for a father, they were not pleased when he
practiced his operating techniques on the family
rabbits and chickens. In response to the protests,
Dr. Hughes would simply reply, “Would you rather
me practice on a person?”3
Despite his dedication to medicine and his
patients, Dr. Hughes loved to escape with his fam-
ily to an island in Rideau Lake in Ontario, Canada,
every summer. His industrious spirit was not lim-
ited to medicine, as he spent numerous hours
performing physical labor to spruce up the island.3
Hughes and his first wife, affectionately known as
“Willie,” discovered this island during their hon-
eymoon in 1929. Sadly, Willie died in 1953 of
colon cancer.
INTERESTS OUTSIDE OF THE HOSPITAL
In addition to his interest in ophthalmology
Fig. 1. Wendell L. Hughes in 1967, 1 year before his retire- and plastic surgery, Hughes also had a passion for
ment. (Photograph courtesy of the American Academy of tennis (Fig. 3) and boating (Fig. 4). He was a
Ophthalmology.) member of the Lighthouse Point Yacht and Rac-
quet Club and could be seen every Thursday wear-
ing his “inevitable port and starboard socks.”
When questioned about this peculiar fashion
statement consisting of one red and one green
sock, he attributed the habit to his time in the
boating world, when he wore them to help him
“remember port from starboard.”4
Hughes showed his enthusiasm for tennis by
donating medallions to the winners of the annual
American Ophthalmology Society women’s tennis
doubles tournament. These medallions were later
replaced by the permanent Wendell Hughes
Bowl.5
He began serious boating in 1955 and traveled
up and down the East Coast to Canada a dozen
times, an activity that both he and his second wife,
Hassie, enjoyed. He pursued his interest to a
higher level, publishing several articles in maga-
zines such as Yachting, Boating, and The Mariner in
addition to lecturing in boating courses offered
Fig. 2. Wendell L. Hughes (below, right), with sister, Helen, and through the Lighthouse Point Yacht Club.3
brother, Vernon, in 1905. (Photograph courtesy of his daughter,
Margaret Smith.) THE ROAD TO OCULOPLASTIC
SURGERY
Historically, ophthalmic plastic surgical pro-
children. He did not believe in self-promotion; cedures were performed by plastic surgeons until
instead, he believed that one should be known for it became evident that greater anatomical and
his deeds and accomplishments and that others functional knowledge of the eye promoted better
would recognize this. He never swore, and be- results with fewer complications. The gradual for-
lieved that if you did not have anything nice to say mation of oculoplastic surgery as a subspecialty
then you should say nothing at all.3 was stimulated by Hughes’ most influential
Like his father, he often brought his daughters teacher, Dr. John Wheeler. Hughes trained under
to the hospital for rounds before school. Although Wheeler at Bellevue Hospital from 1924 to 1935 and
766e
3. Volume 128, Number 6 • Contributions of Wendell L. Hughes
Fig. 3. Hughes (right) during a tennis match with Peter Ballen in
Hong Kong in 1963. (Photograph courtesy of his daughter, Margaret
Smith.)
Fig. 4. Hughes in the captain’s seat. (Photograph courtesy of his
daughter, Margaret Smith.)
later served on his staff at Bellevue and the New York American Academy of Ophthalmology and Oto-
Eye and Ear Infirmary. The dedication of Hughes’ laryngology in the late 1920s. During the first
ground-breaking thesis, Reconstructive Surgery of the course, he covered the entire subject in 1 hour.7
Eyelids, the most comprehensive book on oculoplas- Dr. Wheeler not only was an expert in plastic
tic surgery of its time, reveals Wheeler’s tremendous surgery but was also a founding member of the
influence: “Dedicated to the memory of Dr. John Board of Plastic Surgery. Shortly after its establish-
Martin Wheeler whose skill in the art of ophthalmic ment, Dr. Hughes was nominated for membership
plastic surgery and indefatigable patience in teach- in the Board’s Founders Group. In February of 1940,
ing it, stimulated the author’s special interest in the Hughes received a Certificate of Qualification as a
subject matter of the present thesis.”6 Specialist in Plastic Surgery. Thus, Hughes stood at
Dr. Wheeler trained in New York and then the forefront with several other founding members
served in the military during World War I, obtain- of the Board of Plastic Surgery, including the likes of
ing significant experience on the trauma service. George Pierce, Robert Ivy, and John Davis.8
He developed a strong interest in oculoplastic sur-
gery, and his extensive case reports were published COMMITMENT TO EDUCATION
in the Columbia University Press and were later After Wheeler unexpectedly died while work-
combined as the Collected Papers of Dr. John Martin ing on a stone fence at his family farm in Vermont,
Wheeler.7 Wheeler also led the first instructional Hughes began teaching the ophthalmic plastic
course devoted to oculoplastic surgery at the surgery course of the American Academy of Oph-
767e
4. Plastic and Reconstructive Surgery • December 2011
thalmology and Otolaryngology. Hughes was an Hughes served as President of the American
educational pioneer and was one of the first to Academy of Ophthalmology and Otolaryngology
teach key principles and surgical technique using in 1967 and President of the American Society of
motion pictures. He believed that if you knew the Ophthalmic Plastic and Reconstructive Surgery in
basic principles well, you could apply them to even 1969. He also chaired the Academy’s Plastic Sur-
the most challenging cases. He presented his lec- gery Committee from 1952 to 1968 and was pri-
tures in a detailed clinical way so that all in atten- marily responsible for writing and editing the first
dance could perform the procedure after finish- edition of the Academy’s manual, Ophthalmic Plas-
ing the lecture.9 Because of increased demand, the tic Surgery, in 1961.5 His educational legacy con-
instructional period was subsequently increased to tinues with the annual Wendell L. Hughes Lecture
3 hours of lecture and to two full panels, with Award established by the Academy in 1970. His
Hughes leading one and his fellows Byron Smith former fellows Byron Smith and Alston Callahan
and Alston Callahan leading one.7 Dr. Hughes also were the first two recipients. The Hughes Medal
presented at many early American Society of Plas- (Fig. 5), designed by Byron Smith and commis-
tic and Reconstructive Surgery meetings, includ- sioned by Tiffany & Co., was presented to the
ing a lecture on orbit reconstruction at the 17th annual Hughes Lecture Award recipient, but was
Annual Meeting at the Greenbrier Resort in Lewis- discontinued after the first 2 years because of its
burg, West Virginia.3 high cost.11
Dr. Hughes inspired and motivated his stu-
dents, training over 75 fellows. Several achieved EVOLUTION OF SUTURES AND
their own fame, including renowned oculoplastic NEEDLES
surgeon Byron Smith, who left Yale to train under Dr. Hughes was instrumental in the develop-
Hughes. Together, they opened the first exclusive ment of improved microneedles and sutures. His
oculoplastic surgery clinic in New York in 1941.10 first experience with sutures came at the age of 3,
They later moved the clinic to Cornell University when he suffered facial lacerations and fractures
according to Dr. John Converse’s request.11 after being kicked by a horse. He commented that
Hughes not only taught his fellows the tech- “the heavy needles and coarse sutures left perma-
nical aspect of oculoplastic surgery but also em- nent scarring and sutures marks that would be
phasized their ethical responsibilities. His guiding quite unacceptable today.”12
ethical principle was that operating on a patient is Dr. Hughes was an intense worker who always
a sacred honor and that one must practice under sought to improve current techniques and instru-
the highest possible standards.9 ments. In a time when the atraumatic aspect of
Fig. 5. The Hughes Medal. (Photograph courtesy of the New York University Department of
Ophthalmology.)
768e
5. Volume 128, Number 6 • Contributions of Wendell L. Hughes
surgery was not emphasized and virtually all pro- simultaneously create the transverse fold of the up-
cedures were performed through large, cumber- per lid.13 Overall, this technique led to significant
some incisions, Hughes was meticulous and gen- improvement in both form and function.
tle, combining the precision and delicacy of eye Hughes also made great contributions to the
surgery with oculoplastic surgery.9 However, atrau- field of comprehensive ophthalmology, including
matic technique was difficult to practice without the combined operation for cataract and glau-
the proper tools. Thus, in 1950, Hughes and five coma in 1928 at the New York Eye and Ear Infir-
ophthalmologists met with Howard Zoller, an in- mary. He was initially severely criticized at the
fluential suture company representative, to discuss American Ophthalmological Society meeting,
problems with sutures and needles. This meeting where he reported 29 cases of this combined op-
sparked the development of a surgeon-company eration, in which normal tension and vision were
liaison that had its first meeting in 1953, in which restored in all but one case, and further vision loss
Zoller’s company gathered 22 ophthalmologists caused by uncontrolled glaucoma was prevented
for an in-depth discussion of needles and sutures in 28 of 29 cases.14 Despite this early criticism,
at the annual meeting of the American Academy Hughes successfully reported over 300 cases of this
of Ophthalmology and Otolaryngology. So many combined operation, and the combined proce-
problems were discussed that an annual meeting dure is now the standard of care.4
was established, with Hughes elected chair and Not only did Hughes pioneer new techniques,
serving in that role through the 1965 meeting. he also invented new tools to assist in the educa-
Other surgical subspecialties quickly followed suit. tion of future ophthalmologists and oculoplastic
The Plastic Surgery Panel was established in 1957 surgeons alike. In 1932, Hughes was granted a
and chaired by Dr. Bradford Cannon.12 patent for an ophthalmotrope, a device that would
Hughes worked tirelessly with the panel and represent the globe and “accurately demonstrate
suture manufacturers to discuss problems and, muscle actions of the eyes, which will demonstrate
more importantly, use solutions that have led to certain surgical operations relating to eyes and the
the creation of many surgical products allowing results thereby accomplished, which can be ma-
for the intricate techniques necessary for the su- nipulated to show all actions of the eyes . . . and
perior results that have become the standard in further to show the related muscles cooperating to
plastic surgery. Reverse cutting needles were the give like movements of the eyeballs.”15
first products promoted by the panel. These nee-
dles provided extra sharpness needed in ophthal- The Origins and Evolution of the Hughes Flap
mic surgery and provided 40 percent more Arguably, Hughes’ most famous contribution
strength than their cutting-eyed counterparts.12 to oculoplastic surgery was the tarsoconjunctival
The reverse cutting needle is now commonly used flap, proposed in 1937 and now known as the
in plastic surgery— especially cosmetic proce- “Hughes flap.” Before exploring the origin and
dures, where minimal trauma, early regeneration evolution of this flap, it is important to understand
of tissue, and minimal scar formation are of pri- the developments that preceded it and influenced
mary concern. its creator.
Jacques Reverdin conclusively demonstrated
NEW TECHNIQUES AND INVENTIONS free skin grafting in 1869. He showed that a com-
In addition to improving needles and suture pletely detached piece of human epidermis would
materials, Hughes pioneered many new surgical remain viable with creation of a proper bed, pro-
techniques. In 1955, he described a method for tection, and appropriate contact until tissue union
correcting congenital palpebral phimosis, a spec- had occurred. He demonstrated this by transfer-
trum of deformities characterized by a wide inter- ring small pinch grafts of skin including the stra-
canthal distance with various types of epicanthal tum mucosum that enlarged, providing true epi-
skin folds located at the medial canthus. He pro- thelialization of the affected area and causing
posed a Y-V operation that involved several steps: rapid healing of the granulation tissue.6 Although
(1) elongation of the lateral canthus; (2) shifting free skin grafts were controversial initially, his ar-
the medial canthus nasally and posteriorly, with ticle sparked important developments. Leon Le
recreation of medial canthal depression through re- Fort initially condemned this idea but later devel-
moval of soft tissue; (3) relocation of the lower lac- oped the eponymous full-thickness graft tech-
rimal punctum; and (4) resection of the levator pal- nique eventually used by Hughes.
pebrae superioris, which would serve to increase the Another point that had been previously ne-
vertical diameter of the interpalpebral fissure and glected was the use of one lid structure to rebuild
769e
6. Plastic and Reconstructive Surgery • December 2011
another (i.e., replacing “like with like”). Grad- Wheeler, who stated that “this is one of the most
enigo first proposed the idea in 1870, stating that splendid results of plastic surgery about the eye I
“nothing will reconstruct satisfactory lids as well as have ever seen .... In operations similar to this I
normal lid tissues themselves.”6 Therefore, this led
to the notion that skin should replace skin, tarsus
should replace tarsus, and so forth.
How did Hughes get the idea to replace lower
lid with upper lid? According to Hughes, it was not
until the works of Dantrelle and Tartrois in 1918
and of his mentor John Wheeler in 1921 that the
free grafting of large areas of upper lid to serve as
the donor site for lower lid reconstruction was
properly emphasized. The upper lid skin provides
a perfect match for the lower lid in every aspect—
color, texture, thickness, and pliability.6 In his the-
sis, Hughes displays the influence of Le Fort and
Wheeler, by combining their ideas in two case
reports to recreate a lower lid using a full-thickness
graft from the upper lid.
In 1932, he further proposed a lower lid re-
construction technique that recreated the con-
junctiva. At that time, the current thought was that
lining a graft would cause its demise secondary to
inadequate circulation.16 Hughes criticized cur-
rent methods such as sliding and pedicle flaps for
their lack of lining, because failure to reconstruct
the conjunctiva led to inward curling of the skin
edges. Hughes emphasized that “this rough edge
with its rigid epithelial edge and the innumerable
minute hairs which are always present usually
causes irritation of the eye.”16
Standing his ground just as in 1928 with his
combined cataract operation, Hughes charged
forward and challenged popular belief. He dem-
onstrated that if “sufficiently large raw area is left
on the graft, the lined area is not made too large,
and the bed for the graft is properly prepared, the
operation can be successfully performed, as dem-
onstrated in the procedure here reported.”16 The
stages of the procedure are as follows. First, the
upper and lower lid margins are denuded and
approximated with a double-armed suture. Simul-
taneously, a pocket is made in the upper lid to
encompass a donor graft of mucous membrane
from the patient’s cheek that will become the con-
junctiva of the newly reconstructed lower lid. Sec-
ond, after 3 weeks, the skin and mucous mem-
brane lining from the upper lid are removed and
transplanted to the lower lid. Third, after 6 weeks,
the lid adhesion is severed to create the interpal-
pebral fissure.16 Fig. 6. (Above) A long, shallow, 75 percent lower eyelid defect.
Hughes presented this work before the Oph- (Center) Intraoperative view showing inset of the Hughes flap to
thalmology Section during the New York Academy repair the posterior lamella. (Below) Postoperative view after a
of Medicine meeting in 1933. Present at this meet- full-thickness skin graft to repair the anterior lamella. (Photo-
ing was none other than Hughes’ mentor, John graphs courtesy of Mark Codner, M.D., and W. T. McClellan, M.D.)
770e
7. Volume 128, Number 6 • Contributions of Wendell L. Hughes
tarsus and an outer flap composed of subcutaneous
tissue, skin, and eyelashes.17
The dissection of the upper lid extended 3 mm
beyond the tarsus, without disturbance of the at-
tachment of the levator to its upper border.17 The
lower epithelial border of the upper tarsus was
united to the conjunctival margin in the lower
fornix to reform the posterior lamella, and the
previously undermined cheek skin was attached to
the anterior surface of the tarsus to rebuild the
anterior lamella.
The second stage of this procedure involved
transplanting the lashes. Finally, the third stage
required a transverse incision between the two
rows of lashes and through skin and the tarsus to
Fig. 7. The S.S HOPE. (Photograph courtesy of the Project HOPE
open the interpalpebral fissure.17 Hughes later
Web site.)
became aware of similar procedures in the liter-
ature by Kollner and Dupuy Detemps. Not want-
ing to take credit away from those who deserved it,
have never dared to throw a flap from the upper Hughes addressed this in his thesis but stated that
to the lower lid the way that Dr. Hughes did. He his procedure differed from both of these tech-
showed his skill in plastic surgery in taking the skin niques in essential details.6
from the upper lid so that vitalization was possible; To further improve his procedure, Hughes
then by uniting mucous membrane to mucous published a response dealing with technical de-
membrane, he obtained vitalization without any tails of the tarsoconjunctival flap, addressing sev-
loss of tissue. I think this is quite a feat.”16 eral of the most frequently encountered compli-
In 1937, Hughes built on his success and cations of the procedure: permanent loss of some
sought to achieve the criterion standard of replac- or all lashes, entropion of the lid margin, and
ing like with like by developing the tarsoconjunc- retraction of the upper lid. To resolve the problem
tival flap. Instead of recreating the conjunctiva of lash loss, he revised the transverse incision,
using mucous membrane from the cheek, he used isolating the tarsoconjunctival layer. He proposed
conjunctiva from the ipsilateral upper lid. This tar- making the incision farther back and obliquely
soconjunctival flap involved a three-stage procedure, incising the tarsus to avoid traumatizing the root
much like his aforementioned operation. The first bulbs of the lashes.18
stage involved undermining the skin of the cheek to Hughes also addressed the problem of retrac-
allow it to occupy the space of the former lower lid tion and entropion of the upper lid margin. He
without tension. Next, the upper lid was split into two stressed the importance of extension of the upper
flaps: an inner flap composed of conjunctiva and lid tarsus dissection to the proper height and sev-
Fig. 8. Dr. Hughes (center) in the operating room, educating those around
him. (Photograph courtesy of his daughter, Margaret Smith.)
771e
8. Plastic and Reconstructive Surgery • December 2011
ering the levator and the Muller muscle attach-
¨ W. Thomas McClellan, M.D.
ments from the tarsal surface.18 Morgantown Plastic Surgery Associates
United Center, Suite 350
The Hughes flap has undergone several mod- 1085 Van Voorhis Road
ifications, including revision of the tarsus dissec- Morgantown, W.Va. 26505
tion to leave a portion in the donor site to decrease wtmcclellan@yahoo.com
postoperative deformity, mobilization of the or-
bicularis oculi to provide a vascular bed for the
full-thickness skin graft, and use of a free tarso- ACKNOWLEDGMENTS
conjunctival flap to achieve a one-stage procedure The authors thank Margaret Smith, Nancy Taylor,
for monocular patients.19 Despite these modifica- Jack Eckert, Dr. Richard Lisman, and Dr. Orkan Stasior
tions, Hughes’ procedure has stood the test of for sharing personal details about Dr. Hughes. Without
time. The Hughes flap (Fig. 6) remains a useful them, this article would not have been possible.
technique that has improved patients’ lives for REFERENCES
over 70 years by replacing like with like to produce
1. Hughes WL. The development of ophthalmic plastic surgery.
excellent results in both form and function. Adv Ophthalmic Plast Reconstr Surg. 1986;5:15–23.
2. Hughes WL. Acceptance of the 1986 Distinguished Service
THE FINAL YEARS Award of the Nassau Surgical Society. June 21, 1986.
Although Dr. Hughes retired in 1968, his con- 3. Smith M. Personal communication, 2009.
tributions to society and the medical community 4. Full text of the American Academy of Ophthalmology and
Otolaryngology, oral history recollections of past and present
did not stop there. Inspired by Dr. William B. leaders: Oral history transcript/1998-[ongoing]. Internet Ar-
Walsh, who served as a medical officer during chive. 1996. Available at: http://www.archive.org/stream/
World War I, the S.S. HOPE (Fig. 7) was designed opthamology00spenrich/opthamology00spenrich_djvu.txt.
to be a floating hospital center to provide health Accessed October 31, 2009.
care and education around the world. Once 5. Beard C, Wendell L. Hughes, MD. Trans Am Ophthalmol Soc.
1994;92:16–18.
completed, a call was “put out for American 6. Hughes WL. Reconstructive Surgery of the Eyelids. St. Louis:
doctors, nurses, and technologists to share their Mosby; 1943:42–103.
skills and knowledge with the people of devel- 7. Hughes WL. Personal remembrances regarding plastic sur-
oping nations - teaching while healing.”20 Dr. gery in ophthalmology. (Unpublished book chapter).
Hughes answered this call, and he and his wife 8. Eckert J. Personal communication, 2009.
9. Stasier O. Personal communication, 2009.
Hassie served in Tunisia, providing medical and 10. Ittyerah TP. Ophthalmic plastic surgery. Indian J Ophthalmol.
surgical services and teaching. 1988;36:109.
Dr. Hughes died on February 10, 1994, at the 11. Lisman R. Personal communication, 2009.
age of 93. Instead of flowers, donations were given 12. Hughes WL, Castroviejo R, Blaydes JE, et al. The evolution
to the Florida Lions Eye Bank, a nonprofit orga- of ophthalmic sutures. Ann Plast Surg. 1981;6:48–65.
13. Hughes WL. Surgical treatment of congenital palpebral phi-
nization providing donor eye tissue to ophthal- mosis: The Y-V operation. AMA Arch Ophthalmol. 1955;54:
mologists for corneal transplantation, in addition 586–590.
to supporting a pathology laboratory for the study of 14. Hughes WL. Results of a combination operation for cataract
eye disease and providing resources and tissue for with glaucoma. Trans Am Ophthalmol Soc. 1955;53:127–149;
teaching and research.21 Even in death, Dr. Hughes discussion 150–154.
15. Hughes WL. Ophthalmotrope. U.S. patent 1,881,602. Octo-
continued to contribute to the lives of patients and ber 11, 1932.
the advancement of medical education. 16. Hughes WL. Removal of the lid with plastic repair. Arch
Ophthalmol. 1933;10:198–201.
CONCLUSIONS 17. Hughes WL. A new method for rebuilding a lower lid: Report
Wendell L. Hughes (Fig. 8) was an inspiring of a case. Arch Ophthalmol. 1937;17:1008–1017.
18. Hughes WL. Total lower lid reconstruction: Technical de-
mentor, a gifted educator, a gracious humanitar- tails. Trans Am Ophthalmol Soc. 1976;74:321–329.
ian, and a pioneer in the field of plastic surgery. 19. Rohrich R, Zbar R. The evolution of the Hughes tarsocon-
He was a surgeon loved by his patients and re- junctival flap for lower eyelid reconstruction. Plast Reconstr
spected by his peers and whose contributions are Surg. 1999;104:518–522; discussion 524–526.
profound. As the breadth of plastic surgery ex- 20. Project HOPE. History of Project HOPE, 2009. Available at:
http://www.projecthope.org/ourmission/history.asp. Ac-
pands, we as a profession need to strive for the cessed October 31, 2009.
high ideals held by Dr. Hughes, both in the op- 21. Florida Lions Eye Bank. History of Florida Lions Eye Bank.
erating room and at the bedside. Available at: http://www.fleb.org/. Accessed October 31, 2009.
772e