https://www.aasraw.com/products/crizotinib-powder/ https://www.aasraw.com/ceritinib/ Ceritinib(CAS:1032900-25-6) has been shown to be effective at treating patients whose disease progressed during or shortly after treatment with crizotinib and who currently have very limited treatment options, as well as patients who have not been treated before. Regarding safety, the adverse effects with Ceritinib generally appeared manageable.

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Ceritinib History and Uses
Ceritinib Was Approved For Using in EU
Ceritinib(CAS:1032900-25-6) has been shown to be effective at treating patients whose disease
progressed during or shortly after treatment with crizotinib and who currently have very limited
treatment options, as well as patients who have not been treated before. Regarding safety, the
adverse effects with Ceritinib generally appeared manageable.
The European Medicines Agency therefore decided that Ceritinib’s benefits are greater than its
risks and recommended that it be approved for use in the EU.
Ceritinib was originally given ‘conditional approval’ because there was more evidence to come
about the medicine. As the company has supplied the additional information necessary, the
authorisation has been switched from conditional to full approval.
You must be curious about this product, Let us read more infromation about Ceritinib:
Ceritinib Description
Ceritinib is used for the treatment of adults with anaplastic lymphoma kinase (ALK)-positive
metastatic non-small cell lung cancer (NSCLC) following failure (secondary to resistance or
intolerance) of prior crizotinib therapy. About 4% of patients with NSCLC have a chromosomal
rearrangement that generates a fusion gene between EML4 (echinoderm microtubule-associated
protein-like 4) and ALK (anaplastic lymphoma kinase), which results in constitutive kinase
activity that contributes to carcinogenesis and seems to drive the malignant phenotype.

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Ceritinib exerts its therapeutic effect by inhibiting autophosphorylation of ALK, ALK-mediated
phosphorylation of the downstream signaling protein STAT3, and proliferation of ALK-dependent
cancer cells. Following treatment with crizotinib (a first-generation ALK inhibitor), most tumours
develop drug resistance due to mutations in key “gatekeeper” residues of the enzyme. This
occurrence led to development of novel second-generation ALK inhibitors such as ceritinib to
overcome crizotinib resistance. The FDA approved ceritinib in April 2014 due to a surprisingly
high response rate (56%) towards crizotinib-resistant tumours and has designated it with orphan
drug status.
How Does Ceritinib Work For Treating
NSCLC?
Ceritinib is a selective and potent inhibitor of anaplastic lymphoma kinase (ALK). In normal
physiology, ALK functions as a key step in the development and function of nervous system
tissue. However, chromosomal translocation and fusion give rise to an oncogenic form of ALK
that has been implicated in progression of NSCLC. Ceritinib thus acts to inhibit this mutated
enzyme and stop cell proliferation, ultimately halting cancer progression.Because ceritinib is
considered a targeted cancer therapy, an FDA-approved test is required to determine which
patients are candidates for ceritinib. This test, developed by Roche, is the VENTANA ALK (D5F3)
CDx Assay and is used to identify ALK-positive NSCLC patients who would benefit from
ceritinib treatment.
How About Ceritinib Medical Uses?
Ceritinib(LDK378) is a drug used to treat non-small cell lung cancer that has spread to other parts
of the body and is anaplastic lymphoma kinase (ALK) positive. It is also being studied in the
treatment of other types of cancer. Ceritinib blocks the protein made by the ALK gene. Blocking
this protein may stop the growth and spread of cancer cells. Ceritinib is a type of tyrosine kinase
inhibitor.

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How To Storage Ceritinib(LDK378)?
Keep Ceritinib(LDK378) in the container it came in, tightly closed, and out of reach of children.
Store it at room temperature and away from light, excess heat and moisture (not in the bathroom).
Unneeded medications should be disposed of in special ways to ensure that pets, children, and
other people cannot consume them. However, you should not flush Ceritinib(LDK378) down the
toilet. Instead, the best way to dispose of your medication is through a medicine take-back
program. Talk to your pharmacist or contact your local garbage/recycling department to learn
about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website
for more information if you do not have access to a take-back program.
It is important to keep all medication out of sight and reach of children as many containers (such
as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not
child-resistant and young children can open them easily. To protect young children from
poisoning, always lock safety caps and immediately place the medication in a safe location – one
that is up and away and out of their sight and reach.