disseminated intravascular coagulation

2. BV Injury
Platelet
Activation
Plt-Fusion
Blood Vessel
Constriction
Coagulation
Activation
Stable Hemostatic Plug
Thromibn,
Fibrin
Reduced
Blood flow
Tissue
Factor
Primary hemostatic plug
Neural

4. Fibrinogen
Fibrin Mononer
Fibrin Polymer
Cross Linked
Fibrin
Thrombin
F-XIIIa

5.  Realease of tissue factor
 Widespread endothelial injury

6. Activation of
coagulation
cascade
Widespread
micro
thrombi
Consumption
coagulopathy
Activation of
fibrinolysis
Bleeding

9.  Brain>heart>lungs>kidney>adrenals>spleen
 Disseminated > localised
 Endocrine
adrenals
pituitary

10.  Platelet count ?
 Coagulation factors ?
 Fibrinogen level ?
 PTT ?
 PT ?
 Thrombin time ?
 Fibrin degradation products ?
 Plasmin ?
 Microangipathic HA picture

12. BT Plt PT PTT
Vascular Dis -  - - -
PLT Disorder -  -  - -
Factor 8/9
*Congenital - - - 
Vit K / Liver
*Acquired - -  -
Combined (DIC)   - 