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Alzheimer's Disease
                            50%




Other Causes                           Mixed Alzheimer's/ Vascular Disease
    10%                                               10%




                                           Vascular Disease
                                                 10%
        Dementia with Lewy Bodies
                  20%
                                                 After Perry et al. 1989, 1990


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                               cholinesterase
                         acetylcholine
                            acetylcholine

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   Rivastigmine / Galantamine / Donepezil


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(Nootropics)
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Memantine
   NMDA        N-methyl-D-aspartate receptor
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                       PS1, PS2 Presenilin (Chr 1,14)
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Dementia