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NEWCASTLE DISEASE
 Viral Disease
 Several types of birds
 Highly contagious
 Caused by strains of avian paramyxovirus ...
NEW CASTLE DISEASE VIRUS
Viral Taxonomy
Order: Mononegavirales
Family: Paramyxoviridae
Subfamily: Paramyxovirinae
Genus: A...
Definitions and Synonyms
APMV 1 = Newcastle Disease
Pseudo-fowl pest, pseudovogel-pest, atypische,
Geflugelpest, pseudo-...
NEWCASTLE DISEASE VIRUS
 Pleomorphic
 100-500 nm
 Single-stranded, non segmented,
negative sense RNA
 Hemagglutination...
Hemagglutination (HA)
NDV and other APMV
Due to binding of HN protein to
receptors on the surface of RBC
Chicken RBC ar...
Susceptibility
Temperature: Inactivated by 56°C/3 hours, 60°C/30 min
Inactivated by acid pH
Chemicals: Ether sensitive
...
Hosts
Infection has been demonstrated in at least 241 species
from 27 orders of birds
Chickens are the most susceptible ...
A carrier state can exist in psittacine birds and other
birds
Mortality/morbidity influenced by species, strain of
virus...
Transmission
 Infection may take place by either inhalation or ingestion
 PPMV is shed by feces
 Virus may be present i...
Dissemination of the Disease
 Movement of live birds
 Feral birds, pet/exotic birds, game birds, racing pigeons and comm...
The severity of the disease is
determined by:
 Viral strain
 Dose (level of challenge)
 Route of exposure
 Immune stat...
Clinical Forms
Current Definition
Infections with:
Low virulent viruses
 Virulent viruses – Viscerotropic
Neurotropic
Infection with low virulent
viruses
 Primarily a respiratory condition of sudden onset and rapid spread
 Dyspnea
 Air s...
Infection with virulent viruses
(Exotic ND)
 Conjunctivitis
 Dyspnea
 Severe respiratory signs
 Subcutaneous edema aro...
Prostration
Dyspnea
Facial Edema
Cyanosis of Comb
Conjunctivitis and blepharitis
Conjunctivitis and blefaritis
Salivation and Nasal Discharge
High Mortality and Gasping
Infection with virulent viruses
Neurotrophic Form (aka pneumoencephalitis)
Conjunctivitis
Dyspnea
Tremors
Torticollis
...
Lack of Coordination
Movements of the head
(head shaking)
Torticollis
Torticollis
Torticollis
Paralysis of legs, and wing
droop
Opisthotonos
Gross Lesions
Gross lesions are dependant of the strain. Remarkable
with viscerotropic velogenic viruses
Hemorrhagic les...
Subcutaneal Edema in Neck and
Hemorrhagic Tracheitis
Hemorrhagic Tracheitis
Diphtheritic Laryngo-tracheitis
Fibrinous membranes in oral,
pharyngeal, and esophageal mucosa
Hemorrhages in Proventriculus
Intestinal Hemorrhages
Hemorrhages in Lymphoid Foci
Splenic Necrosis
Intestinal Ulcers
Normal Cecal Tonsils
Hemorrhagic Cecal Tonsils
Necrosis and Hemorrhages in Intestinal
Lymphoid aggregation Sites
Hemorrhagic Cecal Tonsils
Ulcers on cecal tonsils
Hemorrhages in Cloaca
Shrunken and Hemorrhagic Ovaries
Egg Abnormalities
Avian influenza
Fowl cholera
Laryngotracheitis
Infectious bronchitis
Metapneumovirus
Fowl pox (diphtheritic
form)
M...
Definitive Diagnosis
Virus isolation
Detection of hemagglutination
Hemagglutination inhibition
RT-PCR and real time RT...
Isolation and Agglutination
Live attenuated vaccines
B1 (Lentogenic)
LaSota (Lentogenic)
Roakin (Mesogenic)
Vaccine reaction
Recombinant Vaccines
Vectors: Herpesvirus of
turkeys
Fowl poxvirus
Fusion protein gene
In ovo application
Injection
ND is reportable to the World Organization for Animal
Health (OIE)
Zoonotic disease: Conjunctivitis in humans
NEWCASTLE
DISEASE UPDATE in
REGION III
Reported ND cases
Province No.of
Municipalities
No. of
Barangays
No. of Farmers
Afffected
Mortality
Aurora 5 45 1,353 28,8...
ACTIONS UNDERTAKEN
I. Conducted meetings
– Emergency meeting with the provincial, city and municipal
veterinarians on Janu...
INFORMATION AND
EDUCATION CAMPAIGN
– Conducted series of info campaign in the 7 provinces of the region
– Zambales March 1...
VACCINE DISTRIBUTION
PROVINCE REGIONAL
PURCHASED
BAI VACCINE PRIVATE SECTOR
1. Aurora 26,000 - -
2. Bataan 20,000 62,000 5...
VACCINATION REPORT
Aurora – 20,020 heads
Bataan – 12,069 heads
Bulacan – 73,000 heads
Nueva Ecija*
Pampanga – 8,667 heads
...
Memorandum of Agreement
(Anti-Rabies & ND Vaccination)
Memorandum of Agreement
(Anti-Rabies & ND Vaccination)
QUARANTINE ACTIVITIES
–20 Quarantine checkpoints to be set up in the region
– 120 personnel to man the checkpoints will be...
QUARANTINE ACTIVITIES
–Quarantine Check points
–Aurora √ Pampanga x
–Bataan √ Tarlac √
–Bulacan √ Zambales √
–Nueva Ecija √
Creation of the Newcastle Disease
Regional Quick Response Team
 Under the Special Order No. 353 series of 2016, the BAI l...
THANK YOU!
Newcastle disease outbreak in region III by Dr E Lapuz
Newcastle disease outbreak in region III by Dr E Lapuz
Newcastle disease outbreak in region III by Dr E Lapuz
Newcastle disease outbreak in region III by Dr E Lapuz
Newcastle disease outbreak in region III by Dr E Lapuz
Newcastle disease outbreak in region III by Dr E Lapuz
Newcastle disease outbreak in region III by Dr E Lapuz
Newcastle disease outbreak in region III by Dr E Lapuz
Newcastle disease outbreak in region III by Dr E Lapuz
Newcastle disease outbreak in region III by Dr E Lapuz
Newcastle disease outbreak in region III by Dr E Lapuz
Newcastle disease outbreak in region III by Dr E Lapuz
Newcastle disease outbreak in region III by Dr E Lapuz
Newcastle disease outbreak in region III by Dr E Lapuz
Newcastle disease outbreak in region III by Dr E Lapuz
Newcastle disease outbreak in region III by Dr E Lapuz
Newcastle disease outbreak in region III by Dr E Lapuz
Newcastle disease outbreak in region III by Dr E Lapuz
Newcastle disease outbreak in region III by Dr E Lapuz
Newcastle disease outbreak in region III by Dr E Lapuz
Newcastle disease outbreak in region III by Dr E Lapuz
Newcastle disease outbreak in region III by Dr E Lapuz
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Newcastle disease outbreak in region III by Dr E Lapuz

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Newcastle disease outbreak in region III by Dr E Lapuz

  1. 1. NEWCASTLE DISEASE  Viral Disease  Several types of birds  Highly contagious  Caused by strains of avian paramyxovirus serotype 1 (APMV-1)  Respiratory, digestive, and/or neurological manifestations  Zoonotic disease
  2. 2. NEW CASTLE DISEASE VIRUS Viral Taxonomy Order: Mononegavirales Family: Paramyxoviridae Subfamily: Paramyxovirinae Genus: Avulavirus Species: Newcastle Disease Virus Other avian paramyxoviruses
  3. 3. Definitions and Synonyms APMV 1 = Newcastle Disease Pseudo-fowl pest, pseudovogel-pest, atypische, Geflugelpest, pseudo-poultry plague, avian pest, avian distemper, Raniket disease, Tetelo disease, Korean fowl plague, and avian pneumoencephalitis Exotic Newcastle disease: Infections with virulent APMV-1
  4. 4. NEWCASTLE DISEASE VIRUS  Pleomorphic  100-500 nm  Single-stranded, non segmented, negative sense RNA  Hemagglutination activity  Neuraminidase activity  Antigenically homogeneous group  Different Pathotypes!!!
  5. 5. Hemagglutination (HA) NDV and other APMV Due to binding of HN protein to receptors on the surface of RBC Chicken RBC are used for HA test, but NDV can agglutinate all amphibian, reptilian and avian cells
  6. 6. Susceptibility Temperature: Inactivated by 56°C/3 hours, 60°C/30 min Inactivated by acid pH Chemicals: Ether sensitive Disinfectants: Inactivated by formalin and phenol Survival: Survives for long periods at ambient temperature, especially in feces
  7. 7. Hosts Infection has been demonstrated in at least 241 species from 27 orders of birds Chickens are the most susceptible species White leghorns chickens seem to be more susceptible to experimental infection than white rocks Turkeys are more resistant than chickens Waterfowl are believed to be quite resistant
  8. 8. A carrier state can exist in psittacine birds and other birds Mortality/morbidity influenced by species, strain of virus, environmental factors, and vaccination practices Hosts
  9. 9. Transmission  Infection may take place by either inhalation or ingestion  PPMV is shed by feces  Virus may be present in aerosols  Birds in contact with such aerosols become infected  Large amounts of virus are excreted in the feces  Ingestion of these feces result in infection  Vertical transmission remains controversial
  10. 10. Dissemination of the Disease  Movement of live birds  Feral birds, pet/exotic birds, game birds, racing pigeons and commercial poultry  Contact with other animals  Movement of people and equipment  Movement of poultry products  Airborne spread  Contaminated poultry feed  Contaminated water  Vaccines
  11. 11. The severity of the disease is determined by:  Viral strain  Dose (level of challenge)  Route of exposure  Immune status  Age  Host species  Incubation period: 3-8 days
  12. 12. Clinical Forms Current Definition Infections with: Low virulent viruses  Virulent viruses – Viscerotropic Neurotropic
  13. 13. Infection with low virulent viruses  Primarily a respiratory condition of sudden onset and rapid spread  Dyspnea  Air sac lesions related to complicating infections E. coli, ORT  Disease course: 10-14 days  Poor productive performance  NDV isolates from these clinical problems are similar to strain vaccines
  14. 14. Infection with virulent viruses (Exotic ND)  Conjunctivitis  Dyspnea  Severe respiratory signs  Subcutaneous edema around eye (cellulitis)  Diarrhea (may be green)  Prostration  May be neurological signs  Death
  15. 15. Prostration
  16. 16. Dyspnea
  17. 17. Facial Edema
  18. 18. Cyanosis of Comb
  19. 19. Conjunctivitis and blepharitis
  20. 20. Conjunctivitis and blefaritis
  21. 21. Salivation and Nasal Discharge
  22. 22. High Mortality and Gasping
  23. 23. Infection with virulent viruses Neurotrophic Form (aka pneumoencephalitis) Conjunctivitis Dyspnea Tremors Torticollis Wing or leg paralysis The birds are unable to reach the feed or water Death
  24. 24. Lack of Coordination
  25. 25. Movements of the head (head shaking)
  26. 26. Torticollis
  27. 27. Torticollis
  28. 28. Torticollis
  29. 29. Paralysis of legs, and wing droop
  30. 30. Opisthotonos
  31. 31. Gross Lesions Gross lesions are dependant of the strain. Remarkable with viscerotropic velogenic viruses Hemorrhagic lesion in the intestine are characterized of viscerotropic strains Generally, gross lesions are not observed in the central nervous system of birds infected with NDV, regardless of the pathotype
  32. 32. Subcutaneal Edema in Neck and Hemorrhagic Tracheitis
  33. 33. Hemorrhagic Tracheitis
  34. 34. Diphtheritic Laryngo-tracheitis
  35. 35. Fibrinous membranes in oral, pharyngeal, and esophageal mucosa
  36. 36. Hemorrhages in Proventriculus
  37. 37. Intestinal Hemorrhages
  38. 38. Hemorrhages in Lymphoid Foci
  39. 39. Splenic Necrosis
  40. 40. Intestinal Ulcers
  41. 41. Normal Cecal Tonsils
  42. 42. Hemorrhagic Cecal Tonsils
  43. 43. Necrosis and Hemorrhages in Intestinal Lymphoid aggregation Sites
  44. 44. Hemorrhagic Cecal Tonsils
  45. 45. Ulcers on cecal tonsils
  46. 46. Hemorrhages in Cloaca
  47. 47. Shrunken and Hemorrhagic Ovaries
  48. 48. Egg Abnormalities
  49. 49. Avian influenza Fowl cholera Laryngotracheitis Infectious bronchitis Metapneumovirus Fowl pox (diphtheritic form) Mycoplasmosis Psittacosis (chlamydiosis in psittacine birds) Pacheco's parrot disease (psittacine birds) Very virulent infectious bursal disease Differential Diagnosis
  50. 50. Definitive Diagnosis Virus isolation Detection of hemagglutination Hemagglutination inhibition RT-PCR and real time RT-PCR Nucleotide and amino acid sequence analysis
  51. 51. Isolation and Agglutination
  52. 52. Live attenuated vaccines B1 (Lentogenic) LaSota (Lentogenic) Roakin (Mesogenic) Vaccine reaction
  53. 53. Recombinant Vaccines Vectors: Herpesvirus of turkeys Fowl poxvirus Fusion protein gene In ovo application Injection
  54. 54. ND is reportable to the World Organization for Animal Health (OIE) Zoonotic disease: Conjunctivitis in humans
  55. 55. NEWCASTLE DISEASE UPDATE in REGION III
  56. 56. Reported ND cases Province No.of Municipalities No. of Barangays No. of Farmers Afffected Mortality Aurora 5 45 1,353 28,884 Bataan 10 64 358 13,542 Bulacan 6 19 65 3,803 Pampanga 20 157 3,052 46,023 Nueva Ecija 32 800 331 200,000 Tarlac 11 30 50 127,452 Zambales 13 22 184 13,226 TOTAL 97 1,137 5,393 432,930
  57. 57. ACTIONS UNDERTAKEN I. Conducted meetings – Emergency meeting with the provincial, city and municipal veterinarians on January 21, 2016. – Meeting with stakeholders on February 16, 2016 – Meeting with stakeholders on February 26, 2016 – Meeting with stakeholders on April 1, 2016 – Meeting with stakeholders on April 26, 2016 (Anti-Rabies and ND vaccination kick off at CLSU)
  58. 58. INFORMATION AND EDUCATION CAMPAIGN – Conducted series of info campaign in the 7 provinces of the region – Zambales March 1, 2016 – Nueva Ecija March 3, 2016 – Tarlac March 4,2016 – Bataan March 8, 2016 – Bulacan March 10, 2016 – Aurora March 11, 2016 – Pampanga March 29, 2016
  59. 59. VACCINE DISTRIBUTION PROVINCE REGIONAL PURCHASED BAI VACCINE PRIVATE SECTOR 1. Aurora 26,000 - - 2. Bataan 20,000 62,000 50,000 3. Bulacan 15,000 107,000 100,000 4. Nueva Ecija 35,000 - 400,000 5. Pampanga 24,000 300,000 100,000 6.Tarlac 20,000 200,000 200,000 7. Zambales 55,000 60,000 - TOTAL 195,000 729,000 850,000
  60. 60. VACCINATION REPORT Aurora – 20,020 heads Bataan – 12,069 heads Bulacan – 73,000 heads Nueva Ecija* Pampanga – 8,667 heads Tarlac – 115,982 heads Zambales – 8,466 heads TOTAL = 238,204 heads * 100,000 doses of vaccine given to CLSU, 60,000 to Cabiao & 40,000 to Zaragoza
  61. 61. Memorandum of Agreement (Anti-Rabies & ND Vaccination)
  62. 62. Memorandum of Agreement (Anti-Rabies & ND Vaccination)
  63. 63. QUARANTINE ACTIVITIES –20 Quarantine checkpoints to be set up in the region – 120 personnel to man the checkpoints will be hired by BAI – 3 shifts at 2 personnel per shift to be supervised by PVO – traffic barriers to be donated by private sectors Aurora – 2 checkpoints Pampanga – 1 checkpoint Bataan – 1 checkpoint Tarlac – 7 checkpoints Bulacan – 5 checkpoint Zambales – 2 checkpoints Nueva Ecija – 2 checkpoints
  64. 64. QUARANTINE ACTIVITIES –Quarantine Check points –Aurora √ Pampanga x –Bataan √ Tarlac √ –Bulacan √ Zambales √ –Nueva Ecija √
  65. 65. Creation of the Newcastle Disease Regional Quick Response Team  Under the Special Order No. 353 series of 2016, the BAI lead the creation of Regional Quick Response Team (RQRT) for Disease Events and Emergencies.
  66. 66. THANK YOU!

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