Polycystic ovarian syndrome (PCOS) is a hormonal disorder affecting 5-10% of women. PCOS is diagnosed when two of three criteria are present: polycystic ovaries, irregular periods, and high androgen levels. The causes of PCOS include genetic factors, environmental triggers like obesity, and insulin resistance. Women with PCOS have increased risks of diabetes, heart disease, infertility, and endometrial cancer due to chronic high androgen levels and insulin resistance over time if left untreated. Lifestyle changes like diet and exercise can help manage symptoms and reduce health risks.
2. INTRODUCTION
• PCOS could be defined when two of the
three following criteria are present:
1)polycystic ovaries (either 12 or more
peripheral follicles 2-9mm in diameter or
increased ovarian volume > 10 cm3).
2)oligo- or anovulation.
3)clinical and/or biochemical signs of
hyperandrogenism.
3.
4.
5. PREVALENCE
• About 5- 10 % of reproductive age
females have clinical or biochemical signs
of anovulation and androgen excess .
6. ETIOLOGIES
• No one is quite sure what causes PCOS, and it
is likely to be the result of:
1)genetic (inherited)
2)environmental factors.
3)Metabolic disorder (IR)
7. GENETIC FACTOR
• Women with PCOS often have a mother
or sister with the condition, and
researchers are examining the role that
genetics or gene mutations might play in
its development.
9. INSULIN RESISTANCE (IR)
• A malfunction of the body's blood sugar
control system (insulin system) is frequent
in women with PCOS, who often have
insulin resistance and elevated blood
insulin levels, and researchers believe that
these abnormalities may be related to the
development of PCOS.
16. • It is also known that the ovaries of women
with PCOS produce excess amounts of
male hormones known as androgens. This
excessive production of male hormones
may be a result of or related to the
abnormalities in insulin production.
23. DIAGNOSIS
• Diagnosis of PCOS can only be made
when other etiologies have been excluded
(thyroid dysfunction, congenital adrenal
hyperplasia, hyperprolactinaemia,
androgen-secreting tumours and Cushing
syndrome).
24. • In the past (before 2003) :
Necessary Lab Tests or USG
• Now ( after 2003):
Clinical grounds + USG
Lab,only for( IR & DD & Risks ).
25.
26. • A raised luteinising hormone/follicle-stimulating
hormone ratio is no longer a diagnostic criteria
for PCOS owing to its inconsistency.
• Elevated free testosterone level (total
testosterone divided by sex hormone binding
globulin (SHBG) x 100 to give a calculated free
testosterone level)
- Raised in total testosteronereduced
SHBG=doubling free testosterone
27.
28.
29. PCO VS MULTICYSTIC OVARIES
• Polycystic ovaries
– Bilateral
– Multiple cysts
– Cyst dia <10 mm
– Stroma increased
• Multicystic ovaries
– Bilateral
– Multiple cysts
– Cyst dia > 10 mm
– Stroma not
increased
31. TREATMENT
• Aimed at relieving symptoms and preventing
adverse long term effects.
• The target symptoms are:
-Infertility
-Hirsutism
-Amenorrhea
32. • First line treatment- prevention of peripupertal
obesity (50% of PCOS In adolescents are50% of PCOS In adolescents are
obese).obese).
• Life- style modifications:
Diet modification
Weight loss
Exercise
Psychosocial support.
Cessation smoking.
33. A weight loss of only 5% of total body
weight is associated with:
• Decreased insulin levels
• improved menstrual function
• reduced hirsutism and acne
• lower testosterone levels.
36. LONG TERM EFFECTS OF PCOS
PCOS
CVD
Gout
Obesity
Hirsutism
Infertility
Endometrial
Cancer
Gallbladder
Disease
NIDDM
37. NIDDM
• Type II DM or Insulin Resistance (IR)
• Women presenting with PCOS, particularly if:
-they are obese (BMI > 30)
-strong family history of type 2 diabetes or
-they are over the age of 40 years,
are at increased risk of type 2 diabetes and should
be offered a glucose tolerance test.
38. CVD
• It has been suggested that women with PCOS
may have a higher cardiovascular risk than
weight-matched controls with normal ovarian
function.
• Increased cardiovascular risk factors such as
obesity, hyperandrogenism, hyperlipidaemia and
hyperinsulinaemia.
39. • Their abnormal lipid profiles mainly consist of
raised triglycerides, total and low-density
lipoprotein cholesterol.
• The elevation of risk factors in young women
with PCOS may therefore put them at higher risk
of developing accelerated atherosclerosis
resulting in myocardial infarction.
40. ENDOMETRIAL Ca
• It has been known for many years that
severe oligo- and amenorrhoea in the
presence of premenopausal levels of
estrogen can lead to endometrial
hyperplasia and carcinoma.
• In women with PCOS intervals between
menstruation of more than 3 months may
be associated with endometrial
hyperplasia.
41. • Regular induction of a withdrawal bleed
with cyclical gestogens, such as
progestogens, oral contraceptive pills or
the Mirena® intrauterine system would be
advisable in oligomenorrhoeic women with
PCOS.