This document outlines 13 questions to guide recommendations for preventing HIV and other sexually transmitted infections among men who have sex with men and transgender people. The questions compare various prevention interventions like condom use, testing and counseling, screening, vaccination, and behavioral interventions to controls like no intervention or standard care. Outcomes of interest include morbidity, mortality, discrimination, and quality of life. The document also discusses adapting existing WHO guidelines to be more relevant for these populations.