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eHEALTH INTERNATIONAL JOURNAL 
Comparative Effects of Moringa Oleifera Lam. Tea on Normal and Hyperglycemic Patients 
eHEALTH INTERNATIONAL 
A primary resource for reliable information on the application and use of information technology 
in all aspects of health and health care nationally, regionally and internationally. 
Moringa Miracle Tree 
Comparative Effects of Moringa Oleifera Lam. Tea on Normal and 
Hyperglycemic Patients 
Michael Ples1 and Howell Ho1,2 
1Biology Department, De La Salle University-Manila 
2St. Luke’s College of Nursing, Trinity University of Asia 
This article is available from: http://www.ehealthinternational.org/ 
30 
Abstract 
This study evaluates the effects on taking tea prepared from Moringa oleifera Lam. 
on blood sugar levels in humans. Two groups of individuals were tested – people 
with normal fasting blood sugar levels (60-120 mg/dl) and those with hyperglycemic 
fasting blood sugar levels (>120 mg/dl). Among the 43 patients tested, 30 belonged 
to the normal group and 13 to the hyperglycemic group. Results showed that blood 
sugar levels of people in the normal group were not significantly changed 2 hours 
after taking the tea. However, for hyperglycemic individuals, the blood sugar levels 
significantly dropped after 2 hours. A mean drop of 28.15 mg/dl in the blood sugar 
levels was observed among the hyperglycemic patients. The results point to the 
benefit of using Moringa oleifera Lam. tea in the management of hyperglycemia. 
Introduction 
The Philippine government through the 
Department of Heath (DOH) has recently 
intensified the campaign on the use of 
medicinal plants to address the high cost of 
pharmaceutical products. One of the medicinal 
plants that show promising multiple benefits is 
Moringa oleifera Lam., or known as the 
“malunggay” in the local vernacular. In fact, 
the Philippine Information Agency (PIA 2007) 
issued a press release to emphasize the 
economic importance of M. oleifera specifically 
highlighting its medicinal properties. M. 
oleifera is a member of family Moringaceae 
and is commonly known in the Western world 
as horse-radish tree. It was first introduced to 
the Philippines from tropical Asia or Malaya 
way back in the prehistoric era (Guevara et al 
1999). 
The medicinal properties of the different plant 
parts of M. oleifera have long been recog-nized 
in Philippine folk medicine (Quisumbing 
1978). Subsequently, various studies have 
been conducted to validate the ethno-botanical 
practices of indigenous people 
pertaining to the use of this plant. A study 
con 
ducted by Guevarra et al (1999) indicates that 
one of the bioactive compounds of M. oleifera 
namely, niazimicin, has an antitumor promoter 
as it inhibits carcinogenesis when tested 
against mouse skin. Additionally, M. oleifera 
could also significantly reduce the lipid levels 
in blood (Mehta et al. 2003; Chumark et al 
2008). The juice from the leaves and stem 
bark of M. oleifera was found to inhibit 
Staphylococcus aureus (Mehta et al 2003) and 
dermatophytes (Chuang et al. 2007). It is also 
suggested that low concentration of the M. 
oleifera plant extract can be used for the 
regulation of thyroid hormone metabolism 
(Tahiliani and Kar 1999). Moreover, an anti-diabetic 
property is also included among the 
medicinal benefits of M. oleifera (Anwar et al 
2007). 
Among the benefits of M. oleifera, the anti-diabetic 
property may have a significant impact 
among Filipinos. The problems implicating 
diabetes have long been recognized by the 
National Diabetes Commission since its crea-tion 
in 1996. A diabetes survey showed that
eHEALTH INTERNATIONAL JOURNAL 
Comparative Effects of Moringa Oleifera Lam. Tea on Normal and Hyperglycemic Patients 
31 
the crude diabetes prevalence of 5.1% repre-sented 
a 54% increase over the figure (3.3%) 
for a similar population in Luzon in 1982 (Bal-tazar 
et al. 2004). The same survey made by 
Baltazar et al (2004) showed an increase in 
the magnitude of impaired glucose tolerance 
(IGT), which almost doubled from 4.1% in 
1982 to 8.1%. Interestingly, women regis-tered 
a higher prevalence than men for both 
conditions (Baltazar et al 2004; Araneta et al 
2006). Araneta et al (2006) stressed that the 
adoption of Western diet and lifestyle could be 
contributory factors for the increase in the 
incidence of diabetes. 
From these basic tenets, this study was 
designed to evaluate the efficacy of the M. 
oleifera leaf tea in lowering the blood sugar 
levels for two groups categorized as being 
normal and hyperglycemic. However, this 
study does not validate the therapeutic value 
of M. oleifera tea for the management of 
diabetes or hyperglycemia. 
Materials and Methods 
The Participants 
A total of 43 subjects participated in the study. 
Subjects were derived from residents of the 
adopted community of St. Luke’s College of 
Nursing, Trinity University of Asia and were 
regular patients of the health clinic located at 
Sitio Valenzuela, Purok 5, Calumpang, Liliw, 
Laguna, Philippines. The health clinic is under 
the supervision of the said University. 
Determination of blood sugar levels were 
incorporated into the routine check-up 
performed at the clinic. The age of the 
subjects ranged from 21 to 72 years with a 
mean age of 41.60 with most of the 
respondents belonging to the age group of 45 
to 55 (40%). There were 35 (81.4%) female 
and 8 (18.6%) male patients. The subjects 
were told that they were included in the study, 
and a written consent form was signed by the 
individuals consistent with ethical standards 
where human subjects are used in a research 
study. 
Data Collection 
Fasting blood sugar determination was done 
using a glucometer available at the clinic and 
done according to the specifications of the 
manufacturer. Testing was done early morn-ing 
before the respondents had breakfast. 
This reading served as the baseline blood glu-cose 
level. Moringa oleifera Lam.(malunggay) 
leaves were dried and commercially prepared 
according to the specifications of the manufac-turer. 
One tablespoon of leaves was mixed 
into a cup of hot water brewed for 5 minutes 
and each respondent drank one cup of tea. 
Two hours after taking the malunggay tea,the 
blood sugar levels were measured again. Par-ticipants 
in the study were instructed to fast 
until after the second blood sugar measure-ment. 
Statistical Analysis 
The subjects were divided into two groups 
based on fasting blood sugar levels. They were 
classified either as normal or hyperglycaemic. 
Normal fasting blood sugar levels were 
determined as those with readings of 60-120 
mg/dl, while hyperglycaemic fasting blood 
sugar levels were those above 120mg/dl. Of 
the 43 patients, 30 (69.8%) were normal and 
13 (30.2%) were hyperglycaemic. The results 
of the first and second blood sugar readings 
were compared for both groups. Statistical 
significance of the change in blood sugar 
readings was determined using the T-test for 
the normal group and Wilcoxon-Signed-Ranked 
Test for the hyperglycaemic group. Statistical 
computations were done using the Statistical 
Package for Social Scientist Version 15. 
Results and Discussion 
Baseline measurements of fasting blood sugar 
levels showed a low of 76 mg/dl and a high of 
222 mg/dl for the 43 respondents. The mean 
value of the initial blood sugar measurements 
was 108.11 mg/dl. Most of the respondents 
(69.8%) were of normal blood sugar levels. 
Figure 1 shows the differences in values of 
blood sugar levels for the normal and 
hyperglycemic groups. The variability of read-ings 
for the normal group is higher as shown 
in the figure. 
After taking tea, the blood sugar levels 
changed for both groups. Generally, the blood 
sugar levels were lower with a mean value of 
102.62 mg/dl for the 43 respondents. Figure 2 
shows the variability of measurements of sugar 
levels 2 hours after taking the tea. There was 
an increased variability of measurements in 
the hyperglycemic group. However, the 
hyperglycemic group still had a significantly 
higher mean blood sugar level as compared to 
the normal group (t=-2.56, p<0.05). 
The graph in Figure 3 shows the change in 
values for both groups from the initial reading 
to the final reading. There was little change for 
the normal group (t=9.44, p>.1), and this was
eHEALTH INTERNATIONAL JOURNAL 
Comparative Effects of Moringa Oleifera Lam. Tea on Normal and Hyperglycemic Patients 
32 
Moringa Miracle Tree
eHEALTH INTERNATIONAL JOURNAL 
Comparative Effects of Moringa Oleifera Lam. Tea on Normal and Hyperglycemic Patients 
33 
not statistically significant. For the hypergly-cemic 
group, there was a drop in blood sugar 
readings (z=-2.976, p<.01), and this was 
highly significant. The effect of the tea for the 
hyperglycemic group was a significant drop in 
blood sugar level after 2 hours. 
Overall, there was a mean change of +4.33 for 
the normal group and -28.15 for the hypergly-cemic 
group. A comparison of the change in 
blood sugar levels for the normal and the hy-perglycemic 
group showed a significant differ-ence, 
indicating a greater change for the hy-perglycemic 
group (F=16.22, p<0.001). 
Summary and Conclusions 
Moringa oleifera Lam. has many potential uses 
in managing health, especially among diabetic 
patients. Hyperglycaemia is one of the most 
important symptoms of diabetes. Thus the 
treatment of diabetic patients often must take 
into account the anti-hyperglycemic or hypo-glycemic 
effects of treatments protocols. 
This study results showe that taking M. oleifera 
tea had no significant effect on the blood 
sugar levels 2 hours after intake for people 
with initial blood sugar levels that are between 
60-120 mg/dl. However, when the tea is used 
by hyperglycemic patients, the blood sugar 
levels significantly decreased 2 h after intake. 
The mean drop in sugar levels was 28.15 
mg/dl. 
These effects on the blood sugar levels of 
hyperglycemic individuals point to the potential 
use of M. oleifera tea in the management or 
treatment of diabetes. A therapy based on tea 
of M. oleifera would be desirable as it is cheap 
and easy to apply. 
Acknowledgements 
The authors are thankful to the people of Sitio 
Valenzuela, Purok 5, Calumpang, Liliw, Laguna 
for being cooperative and helpful during the 
course of the study. 
Moringa oleifera leaves 
References 
1. Philippine Information Agency Feature: 
Malunggay a must-have veggie. PIA press 
release.2007; August 11, 2007 
2. Guevara AP, C Vargas, H Sakurai, Y Fuji-wara, 
K Hashimoto, T Maoka, M Kozuka, Y Ito, 
H Tokuda and H Nishino. An antitumor pro-moter 
from Moringa oleifera Lam. Mutational 
Res 199; 440: 181-188. 
3. Quisumbing, E. Medicinal Plants of the 
Philippines. Quezon City: Katha Publishing 
1978. 
4. Mehta LK, R Balaraman, AH Amin, PA 
Bafna and OD Gulati Effect of fruits of Moringa 
oleifera on lipid profile of normal and hyper-cholesterolaemic 
rabbits. J Ethnopharmacol 
2003 86: 191-195 
5. Chumark P., P Khunawat, Y Sanvarinda, S 
Phornchirasilp, NP Morales, L Phivthong-ngam, 
P Ratachamnong, S Srisawat and KS Pon-grapeeporm. 
The in vitro and in vivo antioxi-dant 
properties, hypolipademic and antiathero-sclerotic 
activities of water extract of Moringa 
oleifera Lam. leaves. J Ethnophamacol 2008 
116: 439-446 
6. Chuang PH, CW Lee, JY Chou, M Murugan, 
BJ Shieh and HM Chen Anti-fungal activity of 
crude extracts and essential oil of Moringa 
oleifera Lam. Biosource Technol 2007 98: 232- 
236.
eHEALTH INTERNATIONAL JOURNAL 
Comparative Effects of Moringa Oleifera Lam. Tea on Normal and Hyperglycemic Patients 
34 
7. Tahiliani P and A Kar. Role of Moringa 
oleifera leaf extract in the regulation of thyroid 
hormone status in adult male and female rats. 
Pharmacol Res 2000 41: 319-323. 
8. Anwar F, S Latif, M Ashraf and AH Guillani 
Moringa oleifera: a food plant with multiple 
medicinal uses. Phytotherapy 2007 Res 21: 
17-25. 
9. Baltazar JC, CA Ancheta, IB Aban, RE Fer-nando 
and MM Bacilod. Prevalence and corre-lates 
of diabetes mellitus and impaired glucose 
tolerance among adults in Luzon, Philippines. 
Diabetes Res Clin Pract 2004 64: 107-15. 
10. Araneta MSG, DJ Morton, LL Ang, A 
Grandinetti, MAL Abrahan, H Chang, EB Con-nor, 
BL Rodrigiez and DL Wingard Hypergly-cemic 
and type 2 diabetes among Filipino 
women in the Philippines, Hawaii and San 
Diego. Diabetes Res Clin Pract 2006 71: 306- 
312. 
Address reprints to: 
Michael B. Ples, M.D. 
Biology Department, De La Salle University 
2401 Taft Avenue Manila 1004, Philippines 
E-mail: plesm@dlsu.edu.ph 
Moringa Miracle Tree

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Study of diabetes_treatment_with_moringa

  • 1. eHEALTH INTERNATIONAL JOURNAL Comparative Effects of Moringa Oleifera Lam. Tea on Normal and Hyperglycemic Patients eHEALTH INTERNATIONAL A primary resource for reliable information on the application and use of information technology in all aspects of health and health care nationally, regionally and internationally. Moringa Miracle Tree Comparative Effects of Moringa Oleifera Lam. Tea on Normal and Hyperglycemic Patients Michael Ples1 and Howell Ho1,2 1Biology Department, De La Salle University-Manila 2St. Luke’s College of Nursing, Trinity University of Asia This article is available from: http://www.ehealthinternational.org/ 30 Abstract This study evaluates the effects on taking tea prepared from Moringa oleifera Lam. on blood sugar levels in humans. Two groups of individuals were tested – people with normal fasting blood sugar levels (60-120 mg/dl) and those with hyperglycemic fasting blood sugar levels (>120 mg/dl). Among the 43 patients tested, 30 belonged to the normal group and 13 to the hyperglycemic group. Results showed that blood sugar levels of people in the normal group were not significantly changed 2 hours after taking the tea. However, for hyperglycemic individuals, the blood sugar levels significantly dropped after 2 hours. A mean drop of 28.15 mg/dl in the blood sugar levels was observed among the hyperglycemic patients. The results point to the benefit of using Moringa oleifera Lam. tea in the management of hyperglycemia. Introduction The Philippine government through the Department of Heath (DOH) has recently intensified the campaign on the use of medicinal plants to address the high cost of pharmaceutical products. One of the medicinal plants that show promising multiple benefits is Moringa oleifera Lam., or known as the “malunggay” in the local vernacular. In fact, the Philippine Information Agency (PIA 2007) issued a press release to emphasize the economic importance of M. oleifera specifically highlighting its medicinal properties. M. oleifera is a member of family Moringaceae and is commonly known in the Western world as horse-radish tree. It was first introduced to the Philippines from tropical Asia or Malaya way back in the prehistoric era (Guevara et al 1999). The medicinal properties of the different plant parts of M. oleifera have long been recog-nized in Philippine folk medicine (Quisumbing 1978). Subsequently, various studies have been conducted to validate the ethno-botanical practices of indigenous people pertaining to the use of this plant. A study con ducted by Guevarra et al (1999) indicates that one of the bioactive compounds of M. oleifera namely, niazimicin, has an antitumor promoter as it inhibits carcinogenesis when tested against mouse skin. Additionally, M. oleifera could also significantly reduce the lipid levels in blood (Mehta et al. 2003; Chumark et al 2008). The juice from the leaves and stem bark of M. oleifera was found to inhibit Staphylococcus aureus (Mehta et al 2003) and dermatophytes (Chuang et al. 2007). It is also suggested that low concentration of the M. oleifera plant extract can be used for the regulation of thyroid hormone metabolism (Tahiliani and Kar 1999). Moreover, an anti-diabetic property is also included among the medicinal benefits of M. oleifera (Anwar et al 2007). Among the benefits of M. oleifera, the anti-diabetic property may have a significant impact among Filipinos. The problems implicating diabetes have long been recognized by the National Diabetes Commission since its crea-tion in 1996. A diabetes survey showed that
  • 2. eHEALTH INTERNATIONAL JOURNAL Comparative Effects of Moringa Oleifera Lam. Tea on Normal and Hyperglycemic Patients 31 the crude diabetes prevalence of 5.1% repre-sented a 54% increase over the figure (3.3%) for a similar population in Luzon in 1982 (Bal-tazar et al. 2004). The same survey made by Baltazar et al (2004) showed an increase in the magnitude of impaired glucose tolerance (IGT), which almost doubled from 4.1% in 1982 to 8.1%. Interestingly, women regis-tered a higher prevalence than men for both conditions (Baltazar et al 2004; Araneta et al 2006). Araneta et al (2006) stressed that the adoption of Western diet and lifestyle could be contributory factors for the increase in the incidence of diabetes. From these basic tenets, this study was designed to evaluate the efficacy of the M. oleifera leaf tea in lowering the blood sugar levels for two groups categorized as being normal and hyperglycemic. However, this study does not validate the therapeutic value of M. oleifera tea for the management of diabetes or hyperglycemia. Materials and Methods The Participants A total of 43 subjects participated in the study. Subjects were derived from residents of the adopted community of St. Luke’s College of Nursing, Trinity University of Asia and were regular patients of the health clinic located at Sitio Valenzuela, Purok 5, Calumpang, Liliw, Laguna, Philippines. The health clinic is under the supervision of the said University. Determination of blood sugar levels were incorporated into the routine check-up performed at the clinic. The age of the subjects ranged from 21 to 72 years with a mean age of 41.60 with most of the respondents belonging to the age group of 45 to 55 (40%). There were 35 (81.4%) female and 8 (18.6%) male patients. The subjects were told that they were included in the study, and a written consent form was signed by the individuals consistent with ethical standards where human subjects are used in a research study. Data Collection Fasting blood sugar determination was done using a glucometer available at the clinic and done according to the specifications of the manufacturer. Testing was done early morn-ing before the respondents had breakfast. This reading served as the baseline blood glu-cose level. Moringa oleifera Lam.(malunggay) leaves were dried and commercially prepared according to the specifications of the manufac-turer. One tablespoon of leaves was mixed into a cup of hot water brewed for 5 minutes and each respondent drank one cup of tea. Two hours after taking the malunggay tea,the blood sugar levels were measured again. Par-ticipants in the study were instructed to fast until after the second blood sugar measure-ment. Statistical Analysis The subjects were divided into two groups based on fasting blood sugar levels. They were classified either as normal or hyperglycaemic. Normal fasting blood sugar levels were determined as those with readings of 60-120 mg/dl, while hyperglycaemic fasting blood sugar levels were those above 120mg/dl. Of the 43 patients, 30 (69.8%) were normal and 13 (30.2%) were hyperglycaemic. The results of the first and second blood sugar readings were compared for both groups. Statistical significance of the change in blood sugar readings was determined using the T-test for the normal group and Wilcoxon-Signed-Ranked Test for the hyperglycaemic group. Statistical computations were done using the Statistical Package for Social Scientist Version 15. Results and Discussion Baseline measurements of fasting blood sugar levels showed a low of 76 mg/dl and a high of 222 mg/dl for the 43 respondents. The mean value of the initial blood sugar measurements was 108.11 mg/dl. Most of the respondents (69.8%) were of normal blood sugar levels. Figure 1 shows the differences in values of blood sugar levels for the normal and hyperglycemic groups. The variability of read-ings for the normal group is higher as shown in the figure. After taking tea, the blood sugar levels changed for both groups. Generally, the blood sugar levels were lower with a mean value of 102.62 mg/dl for the 43 respondents. Figure 2 shows the variability of measurements of sugar levels 2 hours after taking the tea. There was an increased variability of measurements in the hyperglycemic group. However, the hyperglycemic group still had a significantly higher mean blood sugar level as compared to the normal group (t=-2.56, p<0.05). The graph in Figure 3 shows the change in values for both groups from the initial reading to the final reading. There was little change for the normal group (t=9.44, p>.1), and this was
  • 3. eHEALTH INTERNATIONAL JOURNAL Comparative Effects of Moringa Oleifera Lam. Tea on Normal and Hyperglycemic Patients 32 Moringa Miracle Tree
  • 4. eHEALTH INTERNATIONAL JOURNAL Comparative Effects of Moringa Oleifera Lam. Tea on Normal and Hyperglycemic Patients 33 not statistically significant. For the hypergly-cemic group, there was a drop in blood sugar readings (z=-2.976, p<.01), and this was highly significant. The effect of the tea for the hyperglycemic group was a significant drop in blood sugar level after 2 hours. Overall, there was a mean change of +4.33 for the normal group and -28.15 for the hypergly-cemic group. A comparison of the change in blood sugar levels for the normal and the hy-perglycemic group showed a significant differ-ence, indicating a greater change for the hy-perglycemic group (F=16.22, p<0.001). Summary and Conclusions Moringa oleifera Lam. has many potential uses in managing health, especially among diabetic patients. Hyperglycaemia is one of the most important symptoms of diabetes. Thus the treatment of diabetic patients often must take into account the anti-hyperglycemic or hypo-glycemic effects of treatments protocols. This study results showe that taking M. oleifera tea had no significant effect on the blood sugar levels 2 hours after intake for people with initial blood sugar levels that are between 60-120 mg/dl. However, when the tea is used by hyperglycemic patients, the blood sugar levels significantly decreased 2 h after intake. The mean drop in sugar levels was 28.15 mg/dl. These effects on the blood sugar levels of hyperglycemic individuals point to the potential use of M. oleifera tea in the management or treatment of diabetes. A therapy based on tea of M. oleifera would be desirable as it is cheap and easy to apply. Acknowledgements The authors are thankful to the people of Sitio Valenzuela, Purok 5, Calumpang, Liliw, Laguna for being cooperative and helpful during the course of the study. Moringa oleifera leaves References 1. Philippine Information Agency Feature: Malunggay a must-have veggie. PIA press release.2007; August 11, 2007 2. Guevara AP, C Vargas, H Sakurai, Y Fuji-wara, K Hashimoto, T Maoka, M Kozuka, Y Ito, H Tokuda and H Nishino. An antitumor pro-moter from Moringa oleifera Lam. Mutational Res 199; 440: 181-188. 3. Quisumbing, E. Medicinal Plants of the Philippines. Quezon City: Katha Publishing 1978. 4. Mehta LK, R Balaraman, AH Amin, PA Bafna and OD Gulati Effect of fruits of Moringa oleifera on lipid profile of normal and hyper-cholesterolaemic rabbits. J Ethnopharmacol 2003 86: 191-195 5. Chumark P., P Khunawat, Y Sanvarinda, S Phornchirasilp, NP Morales, L Phivthong-ngam, P Ratachamnong, S Srisawat and KS Pon-grapeeporm. The in vitro and in vivo antioxi-dant properties, hypolipademic and antiathero-sclerotic activities of water extract of Moringa oleifera Lam. leaves. J Ethnophamacol 2008 116: 439-446 6. Chuang PH, CW Lee, JY Chou, M Murugan, BJ Shieh and HM Chen Anti-fungal activity of crude extracts and essential oil of Moringa oleifera Lam. Biosource Technol 2007 98: 232- 236.
  • 5. eHEALTH INTERNATIONAL JOURNAL Comparative Effects of Moringa Oleifera Lam. Tea on Normal and Hyperglycemic Patients 34 7. Tahiliani P and A Kar. Role of Moringa oleifera leaf extract in the regulation of thyroid hormone status in adult male and female rats. Pharmacol Res 2000 41: 319-323. 8. Anwar F, S Latif, M Ashraf and AH Guillani Moringa oleifera: a food plant with multiple medicinal uses. Phytotherapy 2007 Res 21: 17-25. 9. Baltazar JC, CA Ancheta, IB Aban, RE Fer-nando and MM Bacilod. Prevalence and corre-lates of diabetes mellitus and impaired glucose tolerance among adults in Luzon, Philippines. Diabetes Res Clin Pract 2004 64: 107-15. 10. Araneta MSG, DJ Morton, LL Ang, A Grandinetti, MAL Abrahan, H Chang, EB Con-nor, BL Rodrigiez and DL Wingard Hypergly-cemic and type 2 diabetes among Filipino women in the Philippines, Hawaii and San Diego. Diabetes Res Clin Pract 2006 71: 306- 312. Address reprints to: Michael B. Ples, M.D. Biology Department, De La Salle University 2401 Taft Avenue Manila 1004, Philippines E-mail: plesm@dlsu.edu.ph Moringa Miracle Tree