Arteriosclerosis refers to the thickening, hardening, and loss of elasticity of the arterial walls. It is caused by aging, loss of the elastic protein elastin, and thickening of the arterial walls. Cholesterol deposits form beneath the artery endothelium and calcify to form atheromatous plaques, which narrow the arterial lumen. This reduces blood circulation and can lead to heart attack, stroke, hypertension, angina, and peripheral arterial disease.