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HarvestPlus:
                        Progress To Date and
                        Future Challenges

                         Howarth Bouis



HarvestPlus c/o IFPRI
2033 K Street, NW • Washington, DC 20006-1002 USA
Tel: 202-862-5600 • Fax: 202-467-4439
HarvestPlus@cgiar.org • www.HarvestPlus.org
Hidden Hunger




2 billion+ affected   Photo: C. Hotz
% Changes in Cereal & Pulse Production
 & in Population Between 1965 & 1999
                         Cereals                            Pulses                   Population
250

200

150

100

 50

  0
                                       Developing




                                                                                                          Developing
                                                                                     Developing
                                                                        Bangladesh
                          Bangladesh




                                                    India
      India




                                                                                                  World
                                                             Pakistan
              Pakistan
Share of Energy Source & Food Budget in Rural Bangladesh

                  Fish and Meat
  Non-Staple
    plants




                Energy Source         Food Budget




 Staple foods
50% Increase in All Food Prices
    Share of Total Expenditures
   Before                 After


   Staples
Animal                  Staples



 Non-Food             Non-Food
Biofortification-breeding food
crops that are more nutritious




                         Photo: D. Marchand
Photo: ICRISAT




Cost-effective: central one
 time investment
Copenhagen Consensus

      TOP FIVE SOLUTIONS          CHALLENGE
1 Micronutrient supplements for
                                   Malnutrition
  children (vitamin A and zinc)
2 The Doha development agenda         Trade
3 Micronutrient fortification
                                   Malnutrition
  (iron and salt iodization)
4 Expanded immunization
                                    Diseases
  coverage for children


5 Biofortification                 Malnutrition
75% of the poor   25%
Supplementation       Commercial
                          Fortification




Dietary
Diversity
                      Biofortification
#1 Breeding must increase nutrient
  to levels that improve nutrition




Photo: Wolfgang Pfeiffer
Progress in Breeding I


                          • Genetic variation sufficient for
                          conventional breeding

                          • No tradeoff between yield and
                          mineral/vitamin content of seed

                          • Low-cost, high throughput
                          methods to quickly screen
                          promising lines have been
Photo: CIMMYT
                          discovered -- XRF
                Photo: R.A. Stevens        Photo: CIMMYT
Progress in Breeding II

              •Genes identified/
                MAS implemented
              • Invested to
              strengthen NARS
              capacity
              • Biofortified lines
              have been submitted
              to Varietal Release
              Committees
Photo :IRRI
#2 Will extra nutrients be bioavailable at
sufficient levels to improve micronutrient
status?
Retinol Equivalency of provitamin A rich
foods: human studies
                            12:1 assumed in
                            defining Target Levels
           Cassava
Photos: Neil Palmer (CIAT)

#3 Farmers must adopt crops and
 consumers must buy & eat these.
One Crop Released...
               24,000 Households reached
2007-092
               Up to 68% of project HHs adopted
               OSP.

               Up to 47% increase in share of OSP
               in total sweet potato area.
Orange Sweet
Potato (OSP)    Up to a 100% increase in vitamin A
               intakes for infants, children and
Vitamin A      women.
Mozambique
Uganda
Impact on vitamin A intakes
Crops for Africa & Release Dates
   20112                2012                  2012




Cassava              Beans                Maize
Vitamin A            Iron (Zinc)          Vitamin A
Nigeria              Rwanda               Zambia
DR Congo             DR Congo

Crops are high-yielding and with other traits farmers want.
Crops for Asia & Release Dates
 20122                  20132               20132




Pearl Millet          Rice                Wheat
Iron (Zinc)           Zinc                Zinc
India                 Bangladesh          India
                      India               Pakistan

Crops are high-yielding and with other traits farmers want.
Agriculture Minister presents vitamin A
gari and bread to Nigerians
Delivery: New roles for HarvestPlus staff
Harvest of Orange Maize for Nutrition Efficacy Trial
Past History

• Visits to nine Centers in 1993
• Inception meeting, 1994
• CGIAR Micronutrients Project (1995-
  2002) – DANIDA funding
  • IRRI conference 1999
  • ADB project for rice (2000-2002)
• Fast-tracked Challenge Program 2002
• Micronutrient Technical Assistance
  – Target: mostly plant breeders and nutritionists (+ their
    labs)
     • Developing protocols for harvesting crops and sample
       preparation for analysis
          – In-country workshops (training)
     • Identifying sources of contamination in labs and equipment
          – Troubleshooting problems
     • Identifying new ways to analyse for Fe, Zn and carotenoids
          – Rapid screening techniques to get the job done quickly and at
            minimal cost
          – XRF for Fe and Zn; ATR FT-IR for carotenoids
     • Providing nutrient analysis to a large host of HarvestPlus
       collaborators

      Biological Sciences
      Flinders University
• Capacity Building
   – Building up the capacity for labs to do their
     own analysis
      • Rolled out 12 XRF units around the
         world in the past 1.5 years
      • Providing on-going support (through
         visits, electronic correspondence,
         proficiency studies)
      • Setting up phytate analysis at ICDDR,B
         in Bangladesh

• Molecular marker development in wheat
   • Association Mapping Panel
      • 330 genotypes; >90K SNP markers;
         grown in Mexico and India (target
         country)
      • Will use as a training panel for
         genomic selection
      • Also providing analytical and
         physiological support
Biofortified rice to prevent iron deficiency
•   Rice grain is usually milled to remove the oily outer layers that cause
    grain to go rancid – polished rice. Unfortunately, most iron and other key
    micronutrients are also removed. A problem for all of the major cereals.

•   By increasing uptake of iron from soil and the solubility of iron in plant
    tissues, we have generated GM rice lines that have 4-fold more iron in
    polished rice and meet our target concentration of 14 ppm iron.




         C                                The increased iron in polished rice (A) is
                                          positively correlated with nicotianamine
                                          content (B). Recent work at the Australian
                                          Synchrotron shows that the increased iron
                                          (C, in green) accumulates in the outer
                                          endosperm region of the grain.
Food Systems R&D
                Graham Lyons et al

• Agronomic biofortification is feasible for Se (soil or
  foliar), Zn (foliar) & I (soil, for leafy vegs, pasture)
• Biofortified Se in wheat is heat-resistant and highly
  bioavailable
• Nutrition education, utilisation of local food crop
  diversity, village-level crop trials and introduction
  of improved genotypes improve micronutrient
  delivery in deficient populations
• Current food system programs in Pacific, N Aust
  and Indonesia aimed at improving human health
• African studies planned: SeZn+NPKS fertiliser in
  Malawi; nutritional supplement v HIV disease
                                                             Slide 28
Popular Beauregard OSP introduced to Solomon
     Islands by ACIAR & HarvestPlus




                                           Slide 29
Solomon Islands women admiring ACIAR/HarvestPlus
local nutritious food posters at a clinic in Malaita




                                                 Slide 30
Challenges for Phase 3 (2014-18)

Scale up Delivery in Target Countries
  • 10-12 countries
  • Approx. $2 million per country-crop
  • New releases from breeding pipeline
  • Measure impact
Phase I           Phase II            Phase III
                                                                2018 >
2004 - 2008        2009 - 2013         2014 - 2018

              Discovery/Research                      Discovery/Research

              Crop Development                           Development


                                 Crop Delivery

                               Establish new                               Institutionalize
                              partnerships and                                    &
                             delivery modalities                              Integrate
                                                     Mass-scale delivery
                Scientific proof of concept

                 Advocacy+ fundraising
Challenges for Phase 3 (2014-18)

Make Biofortification Sustainable
  • Core breeding activity at ag. research
    centers
  • Work with International NGOs
  • Approval from WHO, SUN etc
  • UN Agencies, e.g. World Food Program
  • Funding from Health donors
  • Spinoff institution – Fund, technical
Why have solutions to
      malnutrition been sought
      outside of agriculture?




Photo: Neil Palmer (CIAT)
In Conclusion …
    “Such intimately related subjects as
    agriculture, food, nutrition and health have
    become split up into innumerable rigid and
    self-contained little units, each in the hands of
    some group of specialists. The experts, …soon
    find themselves…learning more and more about
    less and less…The remedy is to look at the
    whole field covered by crop production, animal
    husbandry, food, nutrition, and health as one
    related subject and…to realize…that the
    birthright of every crop, every animal, and
    every human being is health.”
"
Sir Albert Howard, 1873-1947
 “The Soil and Health,” 1945
HarvestPlus: Progress To Date and Future Challenges

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HarvestPlus: Progress To Date and Future Challenges

  • 1. HarvestPlus: Progress To Date and Future Challenges Howarth Bouis HarvestPlus c/o IFPRI 2033 K Street, NW • Washington, DC 20006-1002 USA Tel: 202-862-5600 • Fax: 202-467-4439 HarvestPlus@cgiar.org • www.HarvestPlus.org
  • 2. Hidden Hunger 2 billion+ affected Photo: C. Hotz
  • 3. % Changes in Cereal & Pulse Production & in Population Between 1965 & 1999 Cereals Pulses Population 250 200 150 100 50 0 Developing Developing Developing Bangladesh Bangladesh India India World Pakistan Pakistan
  • 4. Share of Energy Source & Food Budget in Rural Bangladesh Fish and Meat Non-Staple plants Energy Source Food Budget Staple foods
  • 5. 50% Increase in All Food Prices Share of Total Expenditures Before After Staples Animal Staples Non-Food Non-Food
  • 6. Biofortification-breeding food crops that are more nutritious Photo: D. Marchand
  • 8. Copenhagen Consensus TOP FIVE SOLUTIONS CHALLENGE 1 Micronutrient supplements for Malnutrition children (vitamin A and zinc) 2 The Doha development agenda Trade 3 Micronutrient fortification Malnutrition (iron and salt iodization) 4 Expanded immunization Diseases coverage for children 5 Biofortification Malnutrition
  • 9. 75% of the poor 25%
  • 10. Supplementation Commercial Fortification Dietary Diversity Biofortification
  • 11. #1 Breeding must increase nutrient to levels that improve nutrition Photo: Wolfgang Pfeiffer
  • 12. Progress in Breeding I • Genetic variation sufficient for conventional breeding • No tradeoff between yield and mineral/vitamin content of seed • Low-cost, high throughput methods to quickly screen promising lines have been Photo: CIMMYT discovered -- XRF Photo: R.A. Stevens Photo: CIMMYT
  • 13. Progress in Breeding II •Genes identified/ MAS implemented • Invested to strengthen NARS capacity • Biofortified lines have been submitted to Varietal Release Committees Photo :IRRI
  • 14. #2 Will extra nutrients be bioavailable at sufficient levels to improve micronutrient status?
  • 15. Retinol Equivalency of provitamin A rich foods: human studies 12:1 assumed in defining Target Levels Cassava
  • 16. Photos: Neil Palmer (CIAT) #3 Farmers must adopt crops and consumers must buy & eat these.
  • 17. One Crop Released... 24,000 Households reached 2007-092 Up to 68% of project HHs adopted OSP. Up to 47% increase in share of OSP in total sweet potato area. Orange Sweet Potato (OSP) Up to a 100% increase in vitamin A intakes for infants, children and Vitamin A women. Mozambique Uganda
  • 18. Impact on vitamin A intakes
  • 19. Crops for Africa & Release Dates 20112 2012 2012 Cassava Beans Maize Vitamin A Iron (Zinc) Vitamin A Nigeria Rwanda Zambia DR Congo DR Congo Crops are high-yielding and with other traits farmers want.
  • 20. Crops for Asia & Release Dates 20122 20132 20132 Pearl Millet Rice Wheat Iron (Zinc) Zinc Zinc India Bangladesh India India Pakistan Crops are high-yielding and with other traits farmers want.
  • 21. Agriculture Minister presents vitamin A gari and bread to Nigerians
  • 22. Delivery: New roles for HarvestPlus staff
  • 23. Harvest of Orange Maize for Nutrition Efficacy Trial
  • 24. Past History • Visits to nine Centers in 1993 • Inception meeting, 1994 • CGIAR Micronutrients Project (1995- 2002) – DANIDA funding • IRRI conference 1999 • ADB project for rice (2000-2002) • Fast-tracked Challenge Program 2002
  • 25. • Micronutrient Technical Assistance – Target: mostly plant breeders and nutritionists (+ their labs) • Developing protocols for harvesting crops and sample preparation for analysis – In-country workshops (training) • Identifying sources of contamination in labs and equipment – Troubleshooting problems • Identifying new ways to analyse for Fe, Zn and carotenoids – Rapid screening techniques to get the job done quickly and at minimal cost – XRF for Fe and Zn; ATR FT-IR for carotenoids • Providing nutrient analysis to a large host of HarvestPlus collaborators Biological Sciences Flinders University
  • 26. • Capacity Building – Building up the capacity for labs to do their own analysis • Rolled out 12 XRF units around the world in the past 1.5 years • Providing on-going support (through visits, electronic correspondence, proficiency studies) • Setting up phytate analysis at ICDDR,B in Bangladesh • Molecular marker development in wheat • Association Mapping Panel • 330 genotypes; >90K SNP markers; grown in Mexico and India (target country) • Will use as a training panel for genomic selection • Also providing analytical and physiological support
  • 27. Biofortified rice to prevent iron deficiency • Rice grain is usually milled to remove the oily outer layers that cause grain to go rancid – polished rice. Unfortunately, most iron and other key micronutrients are also removed. A problem for all of the major cereals. • By increasing uptake of iron from soil and the solubility of iron in plant tissues, we have generated GM rice lines that have 4-fold more iron in polished rice and meet our target concentration of 14 ppm iron. C The increased iron in polished rice (A) is positively correlated with nicotianamine content (B). Recent work at the Australian Synchrotron shows that the increased iron (C, in green) accumulates in the outer endosperm region of the grain.
  • 28. Food Systems R&D Graham Lyons et al • Agronomic biofortification is feasible for Se (soil or foliar), Zn (foliar) & I (soil, for leafy vegs, pasture) • Biofortified Se in wheat is heat-resistant and highly bioavailable • Nutrition education, utilisation of local food crop diversity, village-level crop trials and introduction of improved genotypes improve micronutrient delivery in deficient populations • Current food system programs in Pacific, N Aust and Indonesia aimed at improving human health • African studies planned: SeZn+NPKS fertiliser in Malawi; nutritional supplement v HIV disease Slide 28
  • 29. Popular Beauregard OSP introduced to Solomon Islands by ACIAR & HarvestPlus Slide 29
  • 30. Solomon Islands women admiring ACIAR/HarvestPlus local nutritious food posters at a clinic in Malaita Slide 30
  • 31. Challenges for Phase 3 (2014-18) Scale up Delivery in Target Countries • 10-12 countries • Approx. $2 million per country-crop • New releases from breeding pipeline • Measure impact
  • 32. Phase I Phase II Phase III 2018 > 2004 - 2008 2009 - 2013 2014 - 2018 Discovery/Research Discovery/Research Crop Development Development Crop Delivery Establish new Institutionalize partnerships and & delivery modalities Integrate Mass-scale delivery Scientific proof of concept Advocacy+ fundraising
  • 33. Challenges for Phase 3 (2014-18) Make Biofortification Sustainable • Core breeding activity at ag. research centers • Work with International NGOs • Approval from WHO, SUN etc • UN Agencies, e.g. World Food Program • Funding from Health donors • Spinoff institution – Fund, technical
  • 34. Why have solutions to malnutrition been sought outside of agriculture? Photo: Neil Palmer (CIAT)
  • 35. In Conclusion … “Such intimately related subjects as agriculture, food, nutrition and health have become split up into innumerable rigid and self-contained little units, each in the hands of some group of specialists. The experts, …soon find themselves…learning more and more about less and less…The remedy is to look at the whole field covered by crop production, animal husbandry, food, nutrition, and health as one related subject and…to realize…that the birthright of every crop, every animal, and every human being is health.” "
  • 36. Sir Albert Howard, 1873-1947 “The Soil and Health,” 1945

Notes de l'éditeur

  1. First, what is hidden hunger? All at risk of disease and death. Stunted growth, reduced IQ, blindness, illness, and deathThose who survive to adulthood, increased risk of death during child birth, reduced ability to work, lower productivity GDP
  2. Poor people eat least amount of nutrient-rich foods but spend the most on it,.
  3. When food prices go up, staple food consumption is protected at expense of more nutritious foods
  4. Biofort is…Focus on 3 micronutrients that are most limiting vitamin A, zinc, and ironHarvestPlus is breeding food crops with higher micronutrient content that will have a measurable impact on nutritional status at the public health level.
  5. A one-time research investment to develop biofortified crops, low What struck CC was how cost-effective biofort can be..especially…
  6. In 2008, CC came up with top 30 best solutions to GLOBAL challenges, NOT just problems in developing countries! (Fro example, climate change, terrorism were all considered).Biofort was #5…well what is biofort?
  7. Let’s remember that most of the poor are in rural areas where they lack access to more nutritious foods. That is where our efforts are focused and other pieces of the puzzle do not work as well.
  8. Biofortification complements other strategies to reduce micronutrient malnutrition
  9. We have successfully released one crop-orange sweet potato with our partners with very promising results. Children under 5 reported consuming OSP twice a week when available. They tend to eat OSP boiled, and the amount of beta carotene consumed between OSP and other sources then exceeds the US recommended daily allowance for vitamin A when averaged over the week.  We found women consuming more OSP (and vitamin A), and by and large households were consuming OSP they produced themselves.  So there seems to have been enough to go around at their production levels in 2009.  We are planning to do another survey next year to find out how much OSP has been retained by households that participated, to see in part if the vitamin A in the diet is still adequate three years after the project took place. More details on nutrition:  The vitamin A estimated average requirement (EAR) for children is 210-275µg RAE depending on age and 500µg RAE for women. The vitamin A content of OSP in Moz was 726µg/100g in the North.  If we ignore other sources of vitamin A in the diet and focus solely on OFSP (which we normally do not do), and if on average children consume 20-40g of OSP, their average vitamin A intake will be at the EAR level. For non-pregnant and non-lactating women, the equivalent amounts to be at the EAR level are 55-70g. These amounts represent half of a small OSP for children and one small OSP for women (or one half of a medium sized OSP).  Our study participants at 73-81g and 144-165 g of OFSP in children and women respectively at endline far exceeded those amounts.
  10. on breeding nutritious varieties of staple food crops eaten by the word’s poor that have more vitamins and minerals…both in Africa
  11. and in Asia..
  12. Not a controlled trial!Decline in CVD due to several factors
  13. Not a controlled trial!Decline in CVD due to several factors
  14. Make Biofortification Sustainable1st and 2nd yellow orange> make core breeding activity at ag. research centers with independent funding3rd yellow/orange> Work with local and International NGOs for mass-scale delivery (tweaking bur essentially current modalities) work with public (eg WFP) and pvt sector food companies, ag pull etc to develop new modalities of delivery. Codex.To institutionalize need a) seal of approval from WHO, MI etc based on sound efficacy studies and effectiveness. To integrate need buy-in from platforms, eg SUN/CAADP, govt policymakers etc. for biofort. to be integrated into other complmentary approaches.
  15. “Such intimately related subjects as agriculture, food, nutrition and health have become split up into innumerable rigid and self-contained little units, each in the hands of some group of specialists ….. The experts, as their studies become concentrated on smaller and smaller fragments, soon find themselves … learning more and more about less and less. Everywhere knowledge increases at the expense of understanding …" ……The remedy is to look at the whole field covered by crop production, animal husbandry, food, nutrition, and health as one related subject and then to realize the great principle that the birthright of every crop, every animal, and every human being is health.”The Soil and Health, 1945
  16. An English botanist and father of the organic agriculture