1. Alpesh Maru,
5th Semester,
Biomedical Department.
October 5th , 2016
Smaller World of Large Surface Area
Nano Biomaterials

2. o Nanomaterials ¬

3. o Classification of Nanomaterials ¬
(a) 0D spheres and clusters,
(b) 1D nanofibers, wires, and rods,
(c) 2D films, plates, and networks,
(d) 3D nanomaterials.

5. o Tissue regeneration and tissue engineering ¬
 Development of tissues and organs is
typically driven by the the action of
multiple growth factors.
Role of vascular growth factors in vessel formation.
• Stage A: Vasculogenesis
• Stage B: Angiogenic remodelling
• Stage C: Stabilization and maturation
• Stage D: Destabilization
• Stage E: Regression
• Stage F: Sprouting

6. o Tissue regeneration and tissue engineering ¬
 Polymer scaffold fabrication for growth
factor release.
• Growth factors incorporated into polymer
scaffolds by either
(1) mixing with polymer particles before processing
into scaffolds,
(2) pre-encapsulating the factors into polymer
microspheres that are then used to form scaffolds.

7. o Degradable solid polymers ¬

8. o Classes of materials used in vivo ¬
 Biodegradable: Breaks down by hydrolysis or enzymatic cleavage to form metabolized
products
 Bioeliminable: Do not degrade; water-soluble, excretable
 Permanent or retrievable materials: Not degradable or excretable; requires surgery
for removal

9. o Estimated values of e and Lcritical for selected degradable
polymers ¬

10. o Targeted Drug Delivery System ¬

14.  References ¬
i. Introduction to Nanomaterials by A. Alagarasi.
ii. Nanomaterials, Application in medicine & biology by Kim A. Woodrow by University of Washington.
iii. Fundamental of Nanomaterial, MTX9100(M.I.T. Lecture series).