10. The human induced pluripotent stem (iPS) cells have been produced by reprogramming somatic cells (skin fibroblast) with a set of 4 transcription factors. The human iPS-cells show striking similarities in their morphological, gene expression, and functional characteristics to human ES-cells, and seem to have acquired the critical ES-cell characteristics of unlimited growth and potential to differentiate to all cell types of human body. Fibroblasts and iPS Cells. (A) Fibroblasts taken from patient skin. (B) Fibroblasts after treatment with OCT4, SOX2, KLF4, and cMYC. (C) iPS colonies after SB431542 and PD0325901 selection. (D) Detail of iPS colonies pictured in (C). Induced Pluripotent Stem Cells can be derived from a patient skin fibroblasts
56. Second Sight: Retinal Prosthesis Trial Completes First Phase Of Testing Ft. Lauderdale, Fla., May 8 – Researchers from the Keck School of Medicine of the University of Southern California, its Doheny Retina Institute and Second Sight, LLC, are reporting on the initial results of their groundbreaking, FDA-approved feasibility trial of an intraocular retinal prosthesis that appears to be able to restore some degree of sight to the blind.
IR imaging reveals speckled hyper- and hypo-reflectivity. On FAF, there is a hypoautofluorescent center surrounded by a hyperautofluorescent ring. SD-OCT imaging shows a clear optical gap with absent IS/OS, as well as an elevated ELM that is hyper-reflective. There is also choroidal hyper-reflectivity,indicating RPE atrophy.
Some with loss of IS, some both. Not clearly correlated with visual acuity
IR imaging reveals a hypo-reflective outer ring, and a hyper-reflective central lesion. On FAF, there is a slightly hyperautofluorescent outer ring with a more hypoautofluorescent center. The IS/OS loss on OCT corresponds to the inner margin of the outer hypoautofluorescent ring on FAF as well as the hyporeflective area on IR.
Some with loss of IS, some both. Not clearly correlated with visual acuity
Pablo Picasso. Breakfast of a blind man . 1903. This man has deeply sunken eye suggesting that he probably suffers from phthisical bulbi as a result of ocular trauma or failed ocular surgery. The alternative explanation is Leber's congenital amaurosis in which prolonged eye rubbing leads to orbital fat atrophy and enophthalmos. Oil on canvas. The Metropolitan Museum of Art, New York, USA.