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Cd4 t cell_differentiation
- 1. CD Creative Diagnostics ® T Helper (Th) Cells Differentiation
- 2. CD Creative Diagnostics ® T Helper (Th) Cells Mature Th cells express the surface protein CD4 Important in the immune system particularly in the adaptive immune system. CD4+ T cells
- 3. CD Creative Diagnostics ® Orchestrate full panoply of immune responses • Help B cells make antibodies • Induce macrophages to develop enhanced microbicidal activity • Recruit neutrophils, eosinophils, and basophils to sites of infection and inflammation • Product cytokines and chemokines CD4+ T cells
- 4. CD Creative Diagnostics ® Naïve CD4+ T cells activation Thymus Naïve CD4+ T cells APC TRC MHC II CD4 CD28 CD80 antigen T cell APC Activated CD4+ T cells
- 5. CD Creative Diagnostics ® CD4+ T cells differentiation TfhTh2 TregTh17Th1 Th9 Activated CD4+ T cells
- 6. CD Creative Diagnostics ® Th1 cells function GM-CSF Cell mediated inflammation and delayed-type hypersensitivity reactions IFN-γ TNF Lymphotoxin IFN-γ • Increase the expression of TLR by innate immune cells • Promote Ig G class switching • Increase MHC-I and MHC-II antigen presentation • Induce chemokine secretion, macrophage activation and increased phagocytosis • Autoimmune diseases IL-2
- 7. CD Creative Diagnostics ® Th2 cells function Host defense against parasites, allergies and atopic illnesses IL-4 • Important survival factor for lymphocytes • Anti-inflammatory response in autoimmune diseases IL-31 IL-4 IL-5IL-6 IL-10 IL-13 IL-5 • Stimulate antibody production • Enhances eosinophils maturation IL-13 • Inhibit inflammation and Th1-mediated pathology • B cell co-stimulator
- 8. CD Creative Diagnostics ® T17 cells function Host defense against extracellular bacteria and fungi infections CCL20 IL-17 IL-21 IL-22 IL-24 IL-26 TNF IL-17: promote pathology and enhance inflammation and tissue damage
- 9. CD Creative Diagnostics ® Th9 cells function TGF-β Immunity to extracellular parasites IL-9 IL-10 CCL17 CCL22 IL-9: • Promote survival and enhance suppressive function of Tregs • Recruit and accumulate mast cells in certain autoimmune diseases TGF-β Th2 Th9
- 10. CD Creative Diagnostics ® Follicular helper T (Tfh) cells function T-cell help for B cells IL-21 IFN-γ IL-4 IL-17A IL-17F CXCR5 CXCR5 CXCR5 Help to B cells for the generation of germinal centers and long-term protective humoral responses
- 11. CD Creative Diagnostics ® Tregs function Regulation of immune responses and immune tolerance Natural Tregs (nTregs) Induced Tregs (iTregs) Suppress or downregulate induction and proliferation of effector T cells TGF-β IL-10 IL-35
- 12. CD Creative Diagnostics ® CD4+ T Cells Differentiation│ www.creative-diagnostics.com 45-1 Ramsey Road, Shirley, NY 11967, USA 1-631-624-4882 info@creative-diagnostics.com