Metabolism of tryptophan
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Biochemistry from Dr. Dhiraj J Trivedi SDM College of Medical Sciences and Hospital, Dharwad, India
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Metabolism of tryptophan
- 1. Metabolism of Tryptophan Dr. Dhiraj J. Trivedi
- 2. Explain metabolism of Tryptophan. • Tryptophan is essential amino acid. • It is heterocyclic and Aromatic amino acid. • Contains indole ring . • Metabolised to three major Products • 1. Tryptophan to Niacin • 2. Tryptophan to Serotonin , Melatonin • 3. Tryptophan to Indole acetic acid or indole lactic acid
- 5. TRYPTOPHAN TO NIACIN •Important pathway for metabolism •Also called Kynurenine anthranilate pathway •Involved in biosynthesis of Vitamin Niacin
- 6. Tryptophan metabolism Tryptophan Vit B1PO4 Fe O2 Tryptophan dioxygenase N Formyl Kynurenine Iron deficiency leads to block this reaction Liver enzyme Other tissue contain Inoleamine dioxygenase enzyme 1
- 7. Kynurenine Formate Kynurenine formylase N Formyl Kynurenine H2O enters One ‘C’ Pool Tryptophane metabolism After formation of kynurenine Pathway begins to branch 2
- 8. Kynurenine Kynurenine Hydroxylase NADPH + O2 3 – OH-Kynurenine Tryptophane metabolism Hydroxylation Of Kynurenine Anthranilate Alanine Kynurenate Transamination Kynureninase NADP + H2O
- 9. Pyruvate 3 – OH -anthranilic acid KynurinaseB6 – Po4 3 –OH– Kynurenine Alanine Tryptophane metabolism Alanine so produced is glucogenic 3
- 10. 3-OH-anthranilate oxidase Fe+2 2-Amino -3-carboxy Muconate Semialdehyde 3 – OH – antharanilic acid Tryptophane metabolism 2- Acroleyl 3- amino fumarate can be converted to Niacin or Acetyl CO A 4 O2
- 11. Tryptophane metabolism dehydrase Quinolinic acid 2-Amino -3-carboxy Muconate semialdehyde H2O CO2 decarboslase Niacin Or Nicotinic acid α-Keto adipic acid Glutaryl Co A Acetyl coA 60 gms tryptophan -- 1gm Niacin 5 NADPH NADP
- 12. Tryptophan to serotonin And melatonin
- 13. Tryptophan to serotonin Tryptophan NADPH O2 Tryptophane hydroxylase 5-OH Tryptophan 5-OH tryptophan decarboxylase B6Po4 5-OH tryptamine Serotonin CO2 In Liver, H4 Biopterin H2 Biopterin
- 14. •5 hydroxy tryptamine is Serotonin. •Synthesized in gastric mucosa, Brain, Intestine. •Acts as •Neurotransmitter in brain – Stimulator, •Deficiency leads to depression and Schizophrenia •Causes contraction of smooth muscle of arterioles and bronchioles. •Also induces sleep •Responsible for mood elevation, behavior pattern.
- 15. synthesis of Melatonin •Melatonin is Derivative of Tryptophan •It is N- acetyl -5- methoxy tryptamine. •It is sleep inducing molecule. •Responsible of regulation of circadian rhythm. •It has inhibitory effect on gonads •Blocks action of MSH , ACTH In Pineal gland Acetylation N Acetyl Serotonin Methylation Serotonin CH3 Acetyl CoA CoA SH Melatonin SAM SAHC
- 16. 3. Tryptophan to Indole acetic acid or indole lactic acid Minor pathway of tryptophan metabolism
- 17. NH2 Tryptophan CO2 Tryptophan Transaminase α KG Glutamate Indole pyruvic acid NADPH+H+ NADP reductase Indole Lactic acid decarboxylase Indole acetic acid
- 18. Tryptophan NH4 Excreted in Urine Tryptophan decarboxylaseB6Po4 Tryptamine CO2 Indole 3 pyruvate Tryptophan Transaminase Indole acetic acid NH4 MAO O2 Biotin
- 19. Thank You Have a nice time with BIOCHEMISTRY