1. The North Of England
Life Sciences Overview

2. Executive Overview
Business Environment - the North England Proposition
The North of England (NoE) has the scale, skills, diversity, strength of
economy and transport links to provide the perfect base needed to reach
key markets throughout Europe
Profile of North England:
 15 highly ranked Universities in addition to colleges of higher
education dedicated to specific skills in Life Sciences
 42% of new European biopharmaceuticals are developed in the UK
and more than 30% of those are developed in North England
 Home to world-class Bio-Medical companies including:
 Astra-Zeneca/MedImmune (largest R&D Center in the world)
 Merck
 Novartis/Chiron
 Thermo Fisher
 Eli Lilly
 Millipore
 GSK
 Sanofi-Aventis
 BMS
 Low workforce costs - between 15 and 20% lower than greater London area
 Highly strategic location - central UK with fast, easy access to mainland Europe links
 Superb transport infrastructure, including international airports with many direct links to North
America, Europe and the rest of the UK
 A high quality of life and the highest level of professional support for inward investing businesses.
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3. A Skilled labor force leads the UK
Business Environment – Life Sciences
North England is home to over 600 Life Sciences
companies which operate in a collaborative
environment integrating industry, academia and
government
With 1.7 million science and technology workers you
will find the expertise you need
• NOE has a workforce of over 4.3 million,
which is larger than Scotland, N. Ireland
and Denmark combined
• Our pool of 1.7 million science and
technology workers is available to support
advanced technologies
Recruit from a large pool of highly qualified students
and professionals
• NOE has over 100,000 students enrolled
in graduate and undergraduate life
science programs and more than 25,00
graduate each year
• NOE has almost 6,000 postgraduates in
medicine allied subjects
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4. A robust infrastructure driven by research
One example - Wellcome Trust Clinical Research Facility
Pharmaceutical companies in North England benefit from vigorous Government commitment, a
•
receptive regulatory environment and a comprehensive network of support services offering a
broad range of outsourcing opportunities.
Wellcome Trust Clinical Research Facility (http://www.mhs.manchester.ac.uk/wtcrf/) in Manchester
•
allows pre-clinical and clinical trials of tissue engineered products and tissue regeneration reagents
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5. UK Center for Tissue Engineering
UK Centre for Tissue Regeneration (UKCTR) – www.ukcte.org/index.htm
• UKCTR has developed from a research collaboration in Tissue Engineering in the University of
Manchester and the University of Liverpool.
• Research of the UKCTR aims to develop and manufacture a variety of tissues for potential therapeutic
use including: Cartilage, Intervertebral Disc, Material Engineering
• Underpinning these themes is research into cell phenotypes, genetic engineering, biodegradable
materials, 3D scaffolds, host integration, immune response and generic research.
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6. National Biomanufacturing Center
National Biomanufacturing Centre (NBC) http://www.biomanufacturing.co.uk/
• The NBC is a government funded initiative (£34 million), developed as part of the Bionow portfolio, owned by
NWDA and run by a commercial operator, Eden Biodesign
• The NBC delivers much needed design expertise and manufacturing capability to early stage biotechnology
companies and product development programs
• Provides the full range of services necessary to take a novel biopharmaceutical from proof of concept through to
cGMP manufacture for clinical trials
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7. Cancer Research – Christie Hospital NHS Trust and MCRC
The Christie Hospital NHS Trust is the largest and most complex
cancer referral network in the UK.
Together with the Manchester Cancer Research Center (MCRC), the
Paterson Institute and the Wolfson Medical Imaging Centre, it
represents the largest comprehensive cancer center in Europe.
Pharmacy
Computer
Chemistry
Sciences
Other NHS
Engineering
Trusts
MCRC
Faculty of Medical Christie Hospital NHS
Faculty of Medical Christie Hospital NHS
Faculty of Paterson Institute
Faculty of Paterson Institute & Human Sciences Foundation Trust
& Human Sciences Foundation Trust
Life Sciences for Cancer
Life Sciences for Cancer (School of Cancer (Research &
(School of Cancer (Research &
(Cancer Studies) Research
(Cancer Studies) Research & Imaging) Development)
& Imaging) Development)
Manchester Cancer Research Centre - Creating a world leader in the fight against cancer
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8. Cancer Imaging Research: Manchester Strengths
Christie Hospital Phase I/II
14,000 pts/year Derek Crowther Unit
Imaging
Exp. Cancer Medicine
Biomarker Centre
Development
Preclinical
Clinical
CRUK Drugs
Imaging Biomarkers
Small Mol Drug Dev
PET (WMIC)
Biologicals/ Ab
MRI (ISBE/ WMIC)
Cell therapy
CT (Christie)
Pharma
Image Analysis
Imaging Physics
Informatics
Tissue/ Serological Target Identification
Biomarkers Paterson Inst. Cancer Research
Preclinical Imaging
Clin. Exp. Pharmacol.
Fluorescence Imaging
Tissue Bank
3D imaging and reconstruction
Proteomics
Manchester Cancer Research
Wolfson Medical
Centre
Imaging Institute
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9. Bionow – Northwest England’s Biocluster Development Organization
www.bionow.co.uk/
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10. Bionow – Technology Transfer and Commercialization
MerseyBIO Incubator exists to promote and support the transition of quality bioscience research into new
business enterprises in Merseyside in conjunction with the University of Liverpool.
The University of Liverpool Business Gateway, helps commercial and public sector organizations access
the cutting edge knowledge and expertise available from the University.
The University of Manchester Incubator Company Limited (UMIC) is The University's Incubator Facilities
include Europe's first dedicated campus based Manchester Bioscience Incubator, The Core Technology
Facility and the North Campus IT Incubator.
The University of Manchester Intellectual Property Limited (UMIP) is the university's technology transfer and
intellectual property commercialization company. It has been formed by the merger of two very successful
companies, UMIST Ventures and Manchester Innovation.
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11. CELS – Centres of Excellence in Life Sciences
CELS, the Biocluster Organization for the North East of England (http://www.celsatlife.com/)
• CELS acts as a catalyst to develop distinct strengths in research, science and technology within a
selected number of specific Life Sciences fields to create an engine for growth for the regional
healthcare economy.
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12. N8 Centre for Translational Regenerative Medicine (regeNer8)
• N8 is an innovative partnership between the North's eight most research-intensive universities, (Durham, Lancaster,
Leeds, Liverpool, Manchester, Newcastle, Sheffield, and York) that accelerates the development of regenerative
therapies and bring them through to clinic and market.
• The North of England is uniquely positioned in Europe as a centre of basic research excellence in regenerative medicine.
A collaborative regional approach has the potential to add considerable value to this emergent sector.
• The N8 Centre for Translational Regenerative Medicine Within the N8 universities there are over 150 post-doctoral
scientists with research expertise extending across stem cell biology, materials science, bio-processing and tissue
engineering.
• In addition to basic research excellence, the N8 has a track record in forming commercial partnerships and taking ideas
through from concept into clinic.
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13. North East England Stem Cell Institute (NESCI)
• NESCI draws together the North-East's Universities and NHS Trusts, the Centre for Life and the Regional Development
Agency (ONE NorthEast) in a unique interdisciplinary collaboration to convert stem cell research and technologies into
cost effective, ethically robust 21st century health solutions to ameliorate degenerative diseases, the effects of ageing
and serious injury.
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14. NorthEast England Stem Cell Institute (NESCI)
• NESCI researchers draw
from a number of
disciplines to develop and
commercialize leading stem
cell therapies and
diagnostics
• NESCI conducts leading
edge research with Somatic,
Embryonic and Cord Blood
Stem Cell
• A close association with
Clinical Research Hospitals
and surgical centers of
excellence accelerates the
development of cellular
therapies and diagnostics
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15. Newcastle Biomanufacturing Facility
The Newcastle Bio-Manufacturing Facility was designed and built to enable
the production of stem cells and derived cellular products to a clinical
standard
• The facility provides high specification room space, equipment infrastructure
and air-handling capabilities that when combined with the process
management requirements of EU cGMP, will ensure biologics are produced
for safe use in human applications
• The facility was designed as a two suite model to enable the separation of
work involving somatic and embryonic stem cells. Commercial clients will
have exclusive access to up to seven separate Grade B (Class 100, ISO
grade 5) and two Grade C (Class 10,000, ISO grade 7) rooms together with
additional space for QA/QC and storage. Expert Quality Assurance and
Control staff are available at the facility
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16. Notable Companies in Regenerative Medicine, Tissue
Engineering and Cellular Biology
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17. North England Overview
The North of England Consulting Services
The NoE IIA is available to help plan and execute your business
expansion and relocation strategy, objectively, confidentially
and free of charge
Our team can work closely with you and provide the information
you require, including:
 Market feasibility studies
 How to set up a legal entity in the UK
 UK and region specific economic and market information
 Site Selection
 Local supply chain development
 Personnel recruitment and training
 Availability of Government Financial Assistance
 Introductions to private avenues of funding
 Introductions to public and private sector networks of professionals
 Logistics and communications information
 Legal/customs and taxation information
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18. Contact
Scott Kozak
North England Investment Agency
Vice President of Life Sciences
8 Faneuil Hall Market Place
3rd Floor
Boston, MA 02109
Tel: (617) 973-5023
Fax: (617) 973-6406
Email:
scott.kozak@northengland.com
Website: www.northengland.com
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