Deltaic processes are governed by numerous factors including the characteristics of inflowing sediment, receiving basin (e.g. water depth, tidal range, circulation pattern, and wind field), and substrate (e.g. sediment type, erodibility, etc.). This topic is of importance to major deltas, especially those experiencing land loss due to subsidence and sea level rise. The Mississippi River Delta is an example where a number of sediment diversions are considered to minimize and reverse the severe loss of wetlands. Historically, the Mississippi River played a significant role in providing sediment, nutrients, and fresh water to support Louisiana’s coastal wetland system. As such, a systems perspective for regional-scale implementation of diversions is important. Recent field observations, coupled with numerical modeling, provided insights toward a system-scale approach to design, evaluate and operate sediment diversions. These recent research activities investigate the uncertainties associated with morphodynamic processes both on the river and receiving basin sides; and identify the critical parameters influencing the overall magnitude and rate of building new land and sustaining existing wetland areas. Specifically, this research discusses the impact of extracting significant amount of sediment and water from fluvial rivers; the ability to efficiently convey sediment to the receiving basins, and the ability to retain such material to build new land and sustain existing wetland.