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EP STUDY
MINIMUM PROTOCOL
WE’VE TALKED ABOUT…
EQUIPMENT
PATIENT PREPARATION
RELEVANT ANATOMY
CATHETERS and PLACEMENT
BASIC INTERVALS
TESTS OF SN FUNCTION
AND NOW…
EQUIPMENT
PATIENT PREPARATION
RELEVANT ANATOMY
CATHETERS and PLACEMENT
BASIC INTERVALS
TESTS OF SN FUNCTION
ATRIAL and VENTRICULAR EXTRASTIMULUS
TESTING
REFRACTORY PERIODS
‘GAP’
INCREMENTAL PACING
MINIMUM PROTOCOL FOR DIAGNOSTIC EPS
EXTRASTIMULUS TESTING
5
Drive train with a single extra stimulus
S1 S1 S1 S1 S1 S1 S1 S1 S2Sensed
PAUSEDRIVETRAIN
S1-S2
Interval
Sense-S1
Interval
8 paced beat drive train – EP steady state
Extrastimulus
(Coupling interval)
Extra stimuli
S 1 S 1 S 1 S 1 S 1 S 1 S 1 S 1 S 2Sensed
DRIVETRAIN
S 3 S 4
S1 S1 S1 S1 S1 S1 S1 S1 S2Sensed
DRIVETRAIN
S 1 S 1 S 1 S 1 S 1 S 1 S 1 S 1 S2Sensed
DRIVETRAIN
S3
Single
Double
Triple
Atrial Extrastimulus testing
• Dynamic properties of AVN and HPS
conduction
• AVN and RA refractory periods
Atrial Extrastimulus testing
• Dynamic properties of AVN and HPS
conduction
• AVN and RA refractory periods
• Dual AVN physiology
Atrial Extrastimulus testing
• Dynamic properties of AVN and HPS
conduction
• AVN and RA refractory periods
• Dual AVN physiology
• Arrhythmia induction
S2 with long coupling interval
Conduction at
fairly constant
velocity
A2H2 equal or
slightly more than
A1H1
A1H1 80 ms ~ A2H2 95 ms
S1A1 ~ S2A2 ~ 55 ms
H1V1 ~ H2V2 ~ 50 ms
S2 with short coupling interval
Slowing of
Conduction
A1H1 < A2H2
A1H1 80 ms
A2H2 140 ms
S2 with shorter coupling interval
Blocked AES
at AVN
Ventricular Extrastimulus testing
• Retrograde conduction over HPS and AVN
• Accessory pathway conduction
• Arrhythmia induction
Ventricular Extrastimulus testing
• Retrograde conduction over HPS and AVN
• Accessory pathway conduction
• Arrhythmia induction
• Stimulation at RV apex conventionally –
RV apex Stim – distal RBB – HPS – AVN – RA
S2 with long coupling interval
H buried in V
V1A1 almost equal to V2A2
Earliest atrial
activation in HBE
Atleast 30 ms
before HRA
Proximal-to-distal
CS activation
CONCENTRIC
ATRIAL
ACTIVATION
S2 with short coupling interval
S2 with shorter coupling interval
S2 with short coupling interval with
short drive cycle length
Blocked VES at AVN
VA block
Differs with
– ES coupling interval
– Drive cycle length
S2 with short coupling interval
Tissue latency in
local evoked
response
Occurs just above
the tissue refractory
period
Even shorter coupling interval
Blocked VES locally at
RV apex
Loss of ventricular
capture
Ventricular Extrastimulus testing
• Other ‘Normal’ responses
– No VA conduction at all
• Atropine, Isoprenaline
• No VA conduction despite drugs
Ventricular Extrastimulus testing
• Other ‘Normal’ responses
– No VA conduction at all
• Atropine, Isoprenaline
• No VA conduction despite drugs
– Retrograde exit site from AV node maybe near CS
ostium rather than HBE – earliest atrial activation
at Proximal CS
Ventricular Extrastimulus testing
• Other ‘Normal’ responses
– No VA conduction at all
• Atropine, Isoprenaline
• No VA conduction despite drugs
– Retrograde exit site from AV node maybe near CS
ostium rather than HBE – earliest atrial activation
at Proximal CS
• Maneuvers to prove accessory pathway
REFRACTORY PERIODS
EFFECTIVE Refractory Period
• ERP of a tissue
EFFECTIVE Refractory Period
• ERP of a tissue (or a structure)
EFFECTIVE Refractory Period
• ERP of a tissue (or a structure) is the LONGEST
coupling interval that fails to capture the
tissue
EFFECTIVE Refractory Period
• ERP of a tissue (or a structure) is the LONGEST
coupling interval that fails to capture the
tissue (or be conducted over the structure)
FUNCTIONAL Refractory Period
• FRP of a tissue (or a structure) is the
SHORTEST ‘output’ coupling interval that can
be elicited from a tissue (or structure) by any
‘input’ interval
FUNCTIONAL Refractory Period
• FRP of a tissue (or a structure) is the
SHORTEST ‘output’ coupling interval that can
be elicited from a tissue (or structure) by any
‘input’ interval
S1-A1-H1-V1 S2-A2-H2-V2
AVN
HPS
AV conduction system
RELATIVE Refractory Period
• RRP of a tissue (or a structure) is the ‘input’
interval at which the ‘output’ interval just
begins to differ from ‘input’ interval
RELATIVE Refractory Period
• RRP of a tissue (or a structure) is the ‘input’
interval at which the ‘output’ interval just
begins to differ from ‘input’ interval
• This is the point at which Latency or
Decremental conduction begins to occur
• Least commonly measured
• In all tissues, ERP and FRP are ‘length-
dependent’
• So, measured using atleast 2 different drive
cycle lengths
AVNERP
Longest A1A2
interval that fails
to capture HB
A1A2 maybe longer
than S1S2 due to
tissue latency
AVNFRP
Shortest H1H2 in
response to any
A1A2 interval
AVNRRP
Longest A1A2
interval at which
A2H2 exceeds
A1H1
Normal range of refractory periods (ms)
ERP Atria ERP AVN FRP AVN ERP HPS ERP V
150-350 230-430 330-530 330-450 190-290
*Denes, Akhtar, Durrer, Josephsen series
GAP phenomena
ES
conducted
as LBBB
INCREMENTAL ATRIAL PACING
INCREMENTAL VENTRICULAR PACING
MINIMUM PROTOCOL
• Basic intervals
• SNRT and CSNRT
• AES – AVNERP
• AV WCL
• VES – VERP
• VA WCL
• Arrhythmia induction
TO BE CONTINUED….
….NEXT presentations
• Atrial arrhythmias
• Ventricular Pre-excitation and AVRT
• Ventricular arrhythmias
• Catheter ablation

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Electrophysiology study protocol