3. Definition
Also known as:- Pyothorax Or Purulent
Pleuritis. The word Empyema comes from the
greek word Empyein, which means :pus –
producing (suppurates).
Accumulation of Pus in the Pleural cavity.
5. ORGANISMS
The most common:
Staph. aureus .(90% of causes in infants & children)
Strept. pneuomonie.
H. influenzae
6. ETIOLOGY
Lung diseases: Pneumonia (the most common
cause) Lung abscess.
Subphrenic abscess (accumulation of infected fluid
between the diaphragm, liver, and spleen)
Post traumatic.
Post-operative.
Blood spread. (post PE)
Iatrogenic.
8. Pathophysiology
Presence of Parapneumonic Effusion
Release of inflammatory mediators
↑permeability of the capilliaries
Attracts WBCs to the site Escape of albumin & other protein
from the capillaries
↑ Pleural fluid
Presence of Free-flowing, Protein Rich Pleural Fluid (Stage I)
Inflammation worsens
9. Cont…
Attracts more WBCs to the site.
Extensive purulent exudate production.
Initiation of fibroblastic (collagen and other proteins)
activity (Stage II)
Adherence of the two pleural membranes (Stage III)
Formation of a “Peel”
10. CLINICAL STAGES
Acute stage :
within the first 2 weeks of the onset.
Chronic Stage :
after 2 weeks or with the formation of the thick peel
and loculations.
11. Causes of Chronicity:
Inadequate Tube Drainage.
Chronic pulmonary Disease( T.B. or Fungal Infection)
Immuno-supressed patients.
Presence of Foreign body within the pleural space.
12. SYMPTOMS & SIGNS
Fever
Cough & Expectoration.
Pleuretic chest pain.
Easy fatiguability.
Loss of weight.
Night sweating.
13. COMPLICATIONS
Rupture into the lung;
Broncho-Pleural fistula
Spread to the subcutaneous tissue;
Empyema Necessitasis) (extension of an empyema
outward the pleural cavity.)
Septicaemia & septic shock.
15. Light’s criteria
Pleural fluid protein: serum protein > O.5 (1-2 g/dL)
Pleural fluid : serum LDH >0.6 (Lactate dehydrogenase
less than 50% of plasma)
16. Other minor criteria
Cholesterol > 45mg/dl (< 45 mg/dL).
pH <7.2 (7.60-7.64)
Glucose < 50% serum (similar to that of plasma)
17. Goals of the treatment
Treat the infection
Drain the purulent effusion adequately and
completely
Re-expand the lung to fill the pleural space
Eliminate complications and avoid chronicity
18. Antibiotic treatment
As soon as the bacteriologic sample are recovered
Pneumonia
Amoxicillin, Metronidazole
Amox-clavulanic acid
Nosocomial
Tazobactam or Imipenem
Aminoglycoside or Quinolone
Adapted to the laboratory results
21. Primary treatment options
Antibiotics alone;
Récurrent thoracocentèsis
Insertion of chest drain alone or in combination with
fibrinolytics
VATS(Video-Assisted Thoracic Surgery).
Open decortication:- the operation of removing fibrous
scar tissue that prevents expansion of the lung.
22. Thoracocentesis
Big caliber needle
Mostly diagnosis technique
Therapeutically used if the liquid remains.
Theoretically allows pleural lavage
23. Chest Tube
As soon as the liquid is thick
Localization
free: axillary
loculated: Chest imaging using
ultrasonography and/or computed
tomography
Size: 20 à 24
Bedside
24. Pleural Lavage
Isotonic saline
Modalités
3 way stopcock
Directly through the CT: 250 to 500 ml
Cautiously if suspicion of broncho-pleural fistula
Timing:
Immediately after CT placement
Once a day until the liquid is clear
25. NOXYFLEX (noxytioline)
Local disinfectant (formaldéhyde)
2,5 g diluted in at least 100ml isotonic saline
Maximum: 5g/day
Incompatible with iodine polyvidone,chlorhexidin,
chlorine solution, lactic acid
26. Fibrinolytics
Urokinase: 100 000 or 300 000 IU conditioning
Streptokinase: 250000 IU conditioning
250.000 IU in 10-20 ml isotonic saline
Don’t evacuate before 24 to 48 heures
Constantly associated with fever (38-39°C)
Then evacuate
Pleural lavage
clamp 4h ( Chest 1996)
27. Video-assisted thoracic surgery
Collection<10 cm: unusual
Visual control of the CT position
5 mm introducer, 4 mm optical
Collection>10 cm
10 mm introducer
Two or three ports are made in the chest
One port is utilised for the camera and the others for
grasping instruments
Free fluid is evacuated and loculations drained under
thoracoscopic visualisation.
Fibrinous adhesions are separated and the pleural debris
removed from the pleural lining using endoscopic
grasping forceps or by extensive irrigation and suction.
Following the procedure, one or two chest drains are then
placed in the portholes.
29. Physiotherapy
Key to a correct evolution
After CT removal
Often and for a long time…..
Decrease surgery
Decrease long term pain and functionnal limitations