This document discusses non-steroidal synthetic estrogens, including stilboesterol, hexoestrol, dienoestrol, and benzoestrol. It notes that these compounds have estrogenic activity without a steroid skeleton, are low cost alternatives to natural estrogens. Specifically, it provides details on hexoestrol's diastereomeric forms and that the meso form is more potent. It also gives the chemical structures and mentions synthesis routes for each compound.

1. Non Steroidal Oestrogen
Prepared by
Dr. N.GOPINATHAN
ASSISTANT PROFESSOR
DEPARTMENT OF PHARMACEUTICAL
CHEMISTRY
FACULTY OF PHARMACY
SRI RAMACHANDRA UNIVERSITY
CHENNAI-116
TAMILNADU

2. • A large number of synthetic oestrogens
have been prepared which have
oestrogenic activity without having
steroid skeleton.
• Low cost
• Prefered over natural one

3. Stilboesterol
OH
OH
CH3
CH3

5. Hexoestrol
• It contains two asymmetric carbon
atoms
• It exist in diastereomeric forms
• Meso form is more potent than racemic
form which is commercially important.
OH
OH
CH3
CH3

6. Hexoestrol synthesis

7. Dienoestrol
OH
OHCH3
CH3

8. Synthesis of dienoestrol

9. Benzoestrol
CH3
CH3
CH3
OH
OH

10. Synthesis of Benzoestrol