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Spotlight on Pressure Reduction:
Market Overview
Kuldev Singh, M.D., M.P.H.
Professor of Ophthalmology
Director, Glaucoma Service
Stanford University
Glaucoma Patients by Region
0
20
40
60
80
100
120
140
160
2015 2020
NumberofGlaucomaPatients(millions)
Rest of World
Latin America
India
China
Other Wealthy
Nations
Japan
Western Europe
United States
Courtesy of Dave Harmon Market Scope
Glaucoma by Disease Category
Open Angle
42%
Closed
Angle
15%
Secondary
7%
Ocular
Hypertension
36%
125 Million
Courtesy of Dave Harmon Market Scope
Courtesy of Dr. Cynthia Mattox
Glaucoma Prevalence by Age
Prevent Blindness America Future of Vision Report 2014
Courtesy of Dr. Cynthia Mattox
Glaucoma: The Big Picture
 25-50% aware that they have disease*
 Those aware are often not under care
 Those under care are often non compliant
 Unpredictable natural history of disease
 Small percentage go blind
 Lowering IOP reduces but does not eliminate
risk
*Sommer A, et al. Arch Ophthalmol. 1991;109:1990-95.
U.S. Ophthalmologists
Specialty
41%
Courtesy of Dr. Gregory Skuta and AAO Member Services
Comprehensive
with Specialty
19%
Comprehensive
40%
U.S. Specialty Breakdown
Retina/Vitreous
29%
Cornea and External
Disease
18%
Pediatrics and
Strabismus
14%
Oculoplastics and
Orbit
12%
Cataract/Anterior
Segment
8%
Other
3%
Neuro
2%
Refractive
Surgery
1%
Uveitis
1%
Glaucoma
12%
Courtesy of Dr. Gregory Skuta and AAO Member Services
Global Glaucoma Pharmaceutical
Market Revenues by Category
Branded
Prostaglandin
28%
Generic Prostaglandin
7%
Beta Blockers…
Carbonic Anhydrase
Inhibitors
11%
Alpha Agonists
11%
Fixed Combo
Drugs
37%
Other
2%
$4.7 Billion in 2015
Courtesy of Dave Harmon Market Scope
Surgical Trends: 1994-2012
0
20000
40000
60000
80000
100000
120000
140000
160000
180000
200000
Trabec
Tube
CPC
LTP
LPI
Courtesy of Drs. William Rich, Michael Repka and Gregory Skuta
0
50
100
150
200
250
300
2013 2014 2019 (Forecast)
64
64
62
44
46
54
20
42
255
USGlaucomaSurgeries(000)
Filtration Tube Shunts MIGS
U.S. Glaucoma Surgical Procedures
Courtesy of Dave Harmon Market Scope
Spotlight on Pressure Reduction:
Addressing Unmet Needs in Glaucoma Care
More effective first line and adjunctive medications
Glaucoma operation safer than trabeculectomy
Novel drug delivery to improve compliance
SPOTLIGHT ON PRESSURE REDUCTION
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Kuldev Singh, MD, PhD

  • 1. Spotlight on Pressure Reduction: Market Overview Kuldev Singh, M.D., M.P.H. Professor of Ophthalmology Director, Glaucoma Service Stanford University
  • 2. Glaucoma Patients by Region 0 20 40 60 80 100 120 140 160 2015 2020 NumberofGlaucomaPatients(millions) Rest of World Latin America India China Other Wealthy Nations Japan Western Europe United States Courtesy of Dave Harmon Market Scope
  • 3. Glaucoma by Disease Category Open Angle 42% Closed Angle 15% Secondary 7% Ocular Hypertension 36% 125 Million Courtesy of Dave Harmon Market Scope
  • 4. Courtesy of Dr. Cynthia Mattox
  • 5. Glaucoma Prevalence by Age Prevent Blindness America Future of Vision Report 2014 Courtesy of Dr. Cynthia Mattox
  • 6. Glaucoma: The Big Picture  25-50% aware that they have disease*  Those aware are often not under care  Those under care are often non compliant  Unpredictable natural history of disease  Small percentage go blind  Lowering IOP reduces but does not eliminate risk *Sommer A, et al. Arch Ophthalmol. 1991;109:1990-95.
  • 7. U.S. Ophthalmologists Specialty 41% Courtesy of Dr. Gregory Skuta and AAO Member Services Comprehensive with Specialty 19% Comprehensive 40%
  • 8. U.S. Specialty Breakdown Retina/Vitreous 29% Cornea and External Disease 18% Pediatrics and Strabismus 14% Oculoplastics and Orbit 12% Cataract/Anterior Segment 8% Other 3% Neuro 2% Refractive Surgery 1% Uveitis 1% Glaucoma 12% Courtesy of Dr. Gregory Skuta and AAO Member Services
  • 9. Global Glaucoma Pharmaceutical Market Revenues by Category Branded Prostaglandin 28% Generic Prostaglandin 7% Beta Blockers… Carbonic Anhydrase Inhibitors 11% Alpha Agonists 11% Fixed Combo Drugs 37% Other 2% $4.7 Billion in 2015 Courtesy of Dave Harmon Market Scope
  • 10.
  • 12. 0 50 100 150 200 250 300 2013 2014 2019 (Forecast) 64 64 62 44 46 54 20 42 255 USGlaucomaSurgeries(000) Filtration Tube Shunts MIGS U.S. Glaucoma Surgical Procedures Courtesy of Dave Harmon Market Scope
  • 13. Spotlight on Pressure Reduction: Addressing Unmet Needs in Glaucoma Care More effective first line and adjunctive medications Glaucoma operation safer than trabeculectomy Novel drug delivery to improve compliance
  • 14. SPOTLIGHT ON PRESSURE REDUCTION Company Presentations