1. Spotlight on Pressure Reduction:
Market Overview
Kuldev Singh, M.D., M.P.H.
Professor of Ophthalmology
Director, Glaucoma Service
Stanford University
2. Glaucoma Patients by Region
0
20
40
60
80
100
120
140
160
2015 2020
NumberofGlaucomaPatients(millions)
Rest of World
Latin America
India
China
Other Wealthy
Nations
Japan
Western Europe
United States
Courtesy of Dave Harmon Market Scope
3. Glaucoma by Disease Category
Open Angle
42%
Closed
Angle
15%
Secondary
7%
Ocular
Hypertension
36%
125 Million
Courtesy of Dave Harmon Market Scope
5. Glaucoma Prevalence by Age
Prevent Blindness America Future of Vision Report 2014
Courtesy of Dr. Cynthia Mattox
6. Glaucoma: The Big Picture
25-50% aware that they have disease*
Those aware are often not under care
Those under care are often non compliant
Unpredictable natural history of disease
Small percentage go blind
Lowering IOP reduces but does not eliminate
risk
*Sommer A, et al. Arch Ophthalmol. 1991;109:1990-95.
8. U.S. Specialty Breakdown
Retina/Vitreous
29%
Cornea and External
Disease
18%
Pediatrics and
Strabismus
14%
Oculoplastics and
Orbit
12%
Cataract/Anterior
Segment
8%
Other
3%
Neuro
2%
Refractive
Surgery
1%
Uveitis
1%
Glaucoma
12%
Courtesy of Dr. Gregory Skuta and AAO Member Services
9. Global Glaucoma Pharmaceutical
Market Revenues by Category
Branded
Prostaglandin
28%
Generic Prostaglandin
7%
Beta Blockers…
Carbonic Anhydrase
Inhibitors
11%
Alpha Agonists
11%
Fixed Combo
Drugs
37%
Other
2%
$4.7 Billion in 2015
Courtesy of Dave Harmon Market Scope
13. Spotlight on Pressure Reduction:
Addressing Unmet Needs in Glaucoma Care
More effective first line and adjunctive medications
Glaucoma operation safer than trabeculectomy
Novel drug delivery to improve compliance