1) Wheat is the largest crop in Pakistan's agriculture and economy, with production increasing over 500% since 1948. Wheat losses to diseases like rusts cost billions annually. 2) The Crop Diseases Research Institute was established in the 1950s to research rust diseases of wheat and barley, building on the pioneering work of S.F. Hassan. Norman Borlaug congratulated Pakistan on the new research station's potential to solve cereal problems. 3) Recent wheat varieties released in Pakistan like Pirsbak-2013 and Lillema-13 have shown high resistance to yellow rust in screening, but some older varieties like Galaxy-13 are ineffective against the disease. Continuous monitoring of rust pathogens remains important.