1. Proff M.I. Matee Department of Microbiology and Immunology RM 19 Ph: 0713-081162 Email: mmatee@muchs.ac.tz Immunology Principles of the Adaptive Immune Response
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3. What are the hallmarks of the innate immune system? Why adaptive immunity? Discussion
31. COMPARISON OF T CELLS AND B CELLS Reproduced from Brock et al, Biology of microorganisms, 4 th ed. Bone marrow. Bone marrow; Bursa in birds Short-lived/long-lived Fairly mobile/stationary Complement receptors Surface immunoglobulins Antibody synthesis Effector: humoral only Origin: Bone marrow Maturation: Thymus Long-lived Highly mobile No complement receptors No surface Ig No antibody synthesis Effector: cellular & humoral B CELLS T CELLS
44. Innate versus Adaptive immunity Highly specific (T and B cell receptors) Primitive and broad Receptors ++++ - Memory Long (months/yrs) Short (days) Duration ++++ - Self discrimination Yes No (insignificant) Amplification ++++ +/- Regulation Slow (days-wks) Fast (hours-days) Kinetics Adaptive Innate