Medicine 1

1. (Blood poisoning)

2. Presence of unfavorable toxins in
the blood stream
 Derived from bacteria
 Body cells
 Does not include;
Toxicity caused by toxic plants,
insects, organic and inorganic poisons

3. Etiology
Toxins
Antigenic Metabolic
Exotoxins
Endotoxins

4. Exotoxins
Protein substances produced by
bacterial growth out side the body
environment
Example
Black leg
Enterotoxaemia
Botulism

5. Endotoxins
Lipopolysachrides found in
bacterial cell wall
Example
E. coli
Salmonella
Conybacteria spp.

6. Metabolic toxins
 Accumulated due to the incomplete elimination
of toxic metabolites
 Normally eliminated from blood through urine,
feces or detoxified by the liver
Example
 Intestinal impaction: Results in autointoxication
of phenol, cresol, amines from intestines

7. Metabolic toxins
Example
 In hepatitis: Metabolites like glycine, cystene,
glucuronic acid, sulfuric acid are not detoxified by
the liver
 Body tissue damage, histamine and histamine
like substances
 Over eating of carbohydrate rich diet

8. Clinical signs
 Depression, lethargy, anorexia
 Separation from group
 Constipation occasionally diarrhea
 In antigenic toxemia, Inc: in body temp.
while in metabolic toxemia, sub normal
body temp.
 At terminal stages, muscular weakness,

9. Treatment
 Continuous fluid and electrolytes
therapy
 Antibiotics
 Antipyretics
 Steroid therapy