1. www.memotext.com 1877-MEMO.TXT Twitter @memotext MEMOTEXT Corporation Trial with Johns Hopkins University Wilmer Eye Clinic – Funded by Microsoft BeWell Fund Study Title: The Impact of Automated Reminders Linked to a Personal Health Record on Adherence with Glaucoma Medications: The Automated Dosing Reminder Study (ADRS)

2. What Really Works?! What is MEMOTEXT? Overview: Automated Dosing Reminder Study (ADRS) Problem/Hypothesis Methods Moving the Needle Lessons Learned ~ Organic solutions 2

4. Interactive dialogue

5. Inference based …speech, mobile and social media patient adherence solution. 3 of 10

6. What really works?! www.memotext.com Johns Hopkins University: Approached MEMOTEXT® to provide an automated, customized and interactive adherence solution for glaucoma daily medication - a study entitled "The Impact of Automated Dosing Reminders on Medication Adherence using HealthVault“ (ADRS). Launched: June 2009 Prelim results presented at American Glaucoma Society March 2011 Automated reminders linked to a personal health record are a practical option to improve adherence This project received funding from the Microsoft HealthVault Be Well Fund. Lead by: Michael V. Boland, MD, PhD Assistant Professor Director of Information Technology Wilmer Eye Institute and Health Sciences Informatics Johns Hopkins University 4 of 10

8. Problem: lack of patient education

9. Problem: poor adherence in almost half of study patients

10. Problem: patients self –reporting after the fact is not reliable

11. Problem: Lack of patient/family controlHypothesis: The Automated Dosing Reminder Study tested the hypothesis that automated, telecommunication-based reminders can improve adherence with glaucoma medications in patients known to have poor adherence. 5 of 10

12. Methods www.memotext.com Recruitment Channel: JHU Research / Wilmer Eye Clinic directly into Microsoft HealthVault Poor adherence is defined as taking < 75% of doses during the monitored period. N= 428glaucoma patients treated with once daily therapy. Subjects were monitored electronically for 3 months (MEMS, AARDEX group). White coat effect: adherence rate was calculated from 2 weeks after the baseline visit until 2 weeks before the follow-up visit. 6 of 10

13. Methods cont.. enrolment www.memotext.com Recruitment/Enrolment Patients selected Medication: Travatan, Xalatan and Lumigan Frequency (daily/weekly) Media (sms/IVR) Time of message(s) 7 of 10

14. SMS and IVR Calls 49.02 % of voice messages were conf./acknowledged in real time. 2% of calls were snoozed and called back. Patients receive weekly, bi-weekly or daily messages via voice / SMS Acknowledge / confirm action Snooze call Repeat this message 8 of 10

15. Moving the needle 9 of 10

16. Summary…From simple messaging to intelligent dialogues. Medication adherence is a problem in a significant population of glaucoma patients Automated reminders linked to a personal health record: Are a practical option to improve adherence Allow patient or family control over reminders Significantly improve adherence with daily medications A simple, elegant intervention increased adherence by 16% Recommendation was to develop method to predict non-adherent patients. Do the difficult things while they are easy and do the great things while they are small... Lao Tzu 10 of 10

17. Find us to learn about how we create self-learning SMS, speech and social adherence interventions. www.memotext.com amos@memotext.com www.Twitter.com/memotext 877-MEMO.TXT Txt or call me: 416-520-3301 Keep in touch! And they all lived happily ever after…