cordyceps sinensis, cordycepin

1. SECONDARY
metaboliteof higher fungi, CORDYCEPIN: a review
rimasingh
roll-20801914068
reg-142080210069
4th –year
bharattechnology
UNDERTHEGUIDANCEOF
Mrs.RUMPABANERJEE
ASSISTANTPROFESSOR,
DEPARTMENTOF PHARMACEUTICAL
CHEMISTRY
BHARATTECHNOLOGY,ULUBERIA, HOWRAH-711316

2. CONTENTS
1) INTRODUCTION
2) DESCRIPTION
3) CHEMICAL CONSTITUENTS OF CORDYCEPS
4) CORDYCEPIN
5) CHEMICAL STRUCTURE OF CORDYCEPIN
6) MOLECULAR TARGETS OF CORDYCEPIN
7) ROLE OF CORDYCEPIN
8) CONCLUSION
9) REFERENCE

3. INTRODUCTION
SECONDARY METABOLITES OF HIGHER FUNGI
 Secondary metabolites of higher fungi are organic
compounds that are not directly involves in the normal
growth, development or reproduction. It only produces at a
particular growth phase.
 Medicinal higher fungi such as Cordyceps sinensis have been
used as alternative medicine remedy to promote health.
 Medicinal higher fungi involves multiple approaches
including mycological, pharmacological, metabolic,
biosynthetic and molecular techniques.

4. INTRODUCTION
 Cordyceps sinensis is an entomopathogenic fungus (a
fungus that grows on insects) found in mountainous region
of Nepal and Tibet.
 C.sinensis is classified as a medicinal mushroom, and used
as traditional Chinese and Tibetian medicine.
 Main chemical constituent of Cordyceps sinensis is
Cordycepin.

5. DESCRIPTION
CORDYCEPSSINENSIS
Kingdom: Fungi
Division: Ascomycota
Class: Sordariomycetes
Order: Hypocreals
Family: Ophiocordycepitaceae
Genus: Ophiocordyceps
Species: O. sinensis

6. CHEMICAL CONSTITUENTS OF CORDYCEPS
Cordyceps as mushroom contains variety of compounds
including:
1) Cordycepin, seen as the main bioactive compound and
also known as 3’-deoxyadenosine.
2) Ergosterol.
3) ‘Cordycepic Acid’ which is just D-Mannitol.etc

7. CORDYCEPIN
Cordycepin, or 3’-deoxyadenosine, is a derivative of the
nucleoside adenosine, differing from the latter by the absence of
the hydroxyl group in the 3’ position of its ribose part. It was
initially extracted from the fungus Cordyceps sinensis, and now
produced synthetically
IUPAC NAME: 9-(3-Deoxy-β-D-ribofuranosyl)adenine
CHEMICAL FORMULA: C10H13N5O3
MOLAR MASS: 251.25g/mol
MELTING POINT : 255.5°C
(437.9°F; 498.6 K)

8. CHEMICAL STRUCTURE OF CORDYCEPIN

9. MOLECULAR TARGETS OF CORDYCEPIN

10. ROLES OF CORDYCEPIN
CORDYCEPIN ROLE IN CANCEROUS CELL
1) Cordycepin-induces apoptosis and autophagy in breast
cancer cells.
2) Cordycepin-induces apoptosis in human leukemia cells.
3) Cordycepin shown an apoptotic effect on human oral cancer
cell line.
4) Cordycepin induces apoptotic cell death of human brain
cancer through the modulation of autophagy.

11. CORDYCEPIN ROLE IN ORTHOPEDICS
1) Cordycepin helps in osteoarthiritis treatment.
2) Cordycepin prevents bone loss through inhibiting
osteoclastogenesis.

12. CORDYCEPIN ROLE IN INFLAMMATORY
ACTION
Cordycepin alleivates hyperreactivity by attenuating the
inflammatory process.

13. CONCLUSION
For thousands of years, ancient medicinal mushroom have been
found to be an ancient source of secondary metabolites which
are in continuous research study for pharmacological and
therapeutical use as possible treatment of diseases. It has
received much attention due to its broad spectrum biological
activity and is found to interfere with various biochemical
reaction like purine biosynthesis & DNA/RNA synthesis etc. It has
various use like action on hepatic, renal, cardiovascular,
respiration, nervous system, sexual, immunological system & also
as anticancer , anti-aging, antioxidant, anti- inflammatory &
antimicrobial activites.

14. REFERENCE
1)Chen HP, et al; “Secondary metabolites from higher fungi”; Prog Chem
Org Nat Prod; 2017; 106: 1-201.
2) Liu J K; “Seecondary metabolites of higher fungi in China and their
biological activity”; Drug discoveries and Therapeutics; 2007; 1(2):
94-103.
3) Sung G H, et al; “Phylogenetic classification of Cordyceps and
clavicipitaceous fungi”; Studies in mycology; 2007; 57(1): 5-59.
4) Hardeep S Tuli, et al; “Pharmacological and Therapeutic Potential of
Cordyceps with special reference to Cordycepin”; Department of
Biotechnology; Feb 2014; 4(1): 1-12.
5) Yang X, et al; “Cordycepin Alleivates Airway Hyperreactivity In aMurine
Model Of Asthma By Attenuating The Inflammatory Process”; Int
Immunopharmacol; Jun 2015; 26(2): 401-8.

15. THANK YOU