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Intravascular elastography
1. CdK ‘02
ICIN
Intravascular Elastography:
palpating plaques with the finger of IVUS
C.L. de Korte1
, F. Mastik1
, J.A. Schaar1
,
M. Sierevogel1,3
,G. Pasterkamp3
,
P.W. Serruys1
and A.F.W van der Steen1,2
1
Erasmus University, Thoraxcentre, Rotterdam, The Netherlands
2
Interuniversity Cardiology Institute of the Netherlands
3
Experimental Cardiology Laboratory, University Medical Center, Utrecht, The Netherlands
Supported by Netherlands Organization for Scientific Research (NWO)
and the Dutch Technology Foundation (STW)
2. CdK ‘02
ICIN
Background : Vulnerable plaque
que vulnerability :
que composition
• Large lipid pool
Mechanical
properties
• High strain region
• Thin fibrous cap
• presence of Macrophages
3. CdK ‘02
ICIN
Background : Principle of elastography
Soft Harduncompressed
compressed
• The response of tissue to mechanical excitation (e.g.
compression) is a function of its mechanical
properties.
Force Soft Hard
12. CdK ‘02
ICIN
Echogram and elastogram obtained in vivo in Yucatan
strain
1%
0%
Elastic-von Giesson Picro-Sirius red Acid Phosphatase
Polarized light
Circulation (2002) in press
13. CdK ‘02
ICIN
Tissue mean std
Normal segments (n=6) 0.21 0.09
Early fatty lesion (n=9) 0.46 0.17
Early fibrous lesion (n=3) 0.24 0.03
Advanced fibrous lesion (n=6) 0.22 0.04
Strain [%]
*
Strain and plaque composition in Yucatan
Univariate ANOVA on strain
Fat p=0.007
MΦ p=0.966
1 - Specificity
1.00.75.50.250.00
Sensitivity
1.00
.75
.50
.25
0.00
Area=0.952
Circulation (2002) in press