1. DNA polymerase The general mechanism for "B-type" chemistry is shown (a) For the reaction catalyzed by DNA polymerase, identify & draw Nu:, the nucleophile (b) Identify and draw Y, the leaving group for nucleotidyl transfer (c) Identify and draw X, the chemical group retained after nucleotidyl transfer D-type viemisury (d) Draw a concept map centered on the conformational transition of the O-helix in DNA polymerase. Add the following elements with appropriate arrows (pointy for positive reinforcement; blunt for negative impact): VDW interactions; Steric repulsion. (e) Match situations with the molecular interactions in your concept map: situation correct dNTP pairs with template, situation incorrect dNTP pairs with template (f) Compare the frequency of the two situations. Be specific with numbers describing the probability of correct dNTP versus incorrect dNTP arriving at the active site..