The document describes the crystal structure determination of the main protease (Mpro) of SARS-CoV-2. Zhang and coworkers found that Mpro forms a tight homodimer with a contact interface of 1394A2 between domain II of one monomer and the NH2-terminal residues of the other monomer oriented perpendicular to each other. Figure 2 depicts the three-dimensional structure of SARS-CoV-2 Mpro as a homodimer.
Q4-1 Homework Answered Due Today, 11-59 PM How would you describe.pdf
1. Q4-1 Homework * Answered * Due Today, 11-59 PM How would you describe the quaternary
structure of this enzyme? 5elect an answer and submit. For keyboard navigotion, use the
up/down arrow keys to select an answer. a Homodimer b Heterodimer c homotrimer d
Heterotrimer e Dimer of heterotrimer Trimer of homodimer g. Monomer Answered-incorrect - 0
attempt left if Besubmit
Zhang and coworkers determined the crystal structure, at 1.75A resolution, of the Mpro of
SARS-CoV- 2 . The three-dimensional structure is highly similar to that of the SARS-CoV
Mpro, as expected from the 96% sequence identity shown in Figure S8. The tight dimer formed
by SARS-CoV-2 Mpro has a contact interface of 1394A2, predominantly between domain II of
molecule A and the NH2-terminal residues ("Nfinger") of molecule B, with the two molecules
oriented perpendicular to one another. Figure. 2 Three-dimensional structure of SARS.CoV-2
Mpro in two different views. One monomer of the dimer is shown in light blue, the other one in
orange. Domains are labeled by Roman numerals. Amino acid residues of the catalytic site are
indicated as yellow spheres for Cys 145 and blue spheres for His41.
crforchilecule 1 (arathel. Q.
Question 4. Interpret Figure 2 without reading the paper. Zhang and coworkers determined the
crystal structure, at 1.75 A resolution, of the Mpro of SARS-CoV-2. The three-dimensional
structure is highly similar to that of the SARS-CoV Mpro, as expected from the 96% sequence
identity shown in Figure S8. The tight dimer formed by SARS-CoV-2 Mpro has a contact
interface of 1394A2, predominantly between domain II of molecule A and the NH2-terminal
residues ("Nfinger") of molecule B, with the two molecules oriented perpendicular to one
another.
Homework = Answered * Due Today, I1s9 pM How would you describe the quaternary structure
of this enzyme? Select an answer and submit. For keyboard anvigation, use theup/down arrow
keys to select an antwer. a Homodimer b Heterodimer c homotrimer d Heterotrimer e Dimer of
heterotrimer 1 Trimer of homodimer Your answer 8. Monomer Answered-Incorrect = 0 attempt
left of Resubmit
![Q4. [15pts.] Complete the following table by writing the correspondin.pdf](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)