5. www.invivosciences.com 5
Table 1. Key Industry Parameters: Tissue Engineering and Stem Cell
Therapeutics
Worldwide estimates (in millions) 2007 2011 Factor
Total sector activity $2400 $3600 1.5x
Total commercial stage spending $1600 $2820 1.8x
Total development stage spending $860 $780 0.9x
Number of FTEs (full time employee) 6100 13,810 2.3x
Capital value of listed firms (36) $4700 $6580 1.4x
Number of companies 171 202 1.2x
Number of companies in commercial
stage
47 62 1.3x
Number of companies providing services 44
Number of companies with products in
clinical trials
57 60 1.1x
Progress in the Tissue Engineering and Stem Cell Industry “Are we there yet?”
Ana Jaklenec, Andrea Stamp, Elizabeth Deweerd, Angela Sherwin, and Robert Langer. Tissue Engineering Part B: Reviews. June 2012, 18(3): 155-166.
doi:10.1089/ten.teb.2011.0553.
7. Contact for both companies:
Ayla Annac, CEO InvivoSciences, Inc.
aannac@invivosciences.com
608-628-8035
Tetsuro Wakatsuki, CSO InvivoSciences, Inc.
tetsuro@invivosciences.com
608-566-6162
7www.invivosciences.com
9. COOK PHARMICA OVERVIEW
ABOUT COOK PHARMICA
• Contract development and manufacturing organization (CDMO)
• Over 450 full-time employees
• Wholly-owned subsidiary of Cook Medical
• Legacy of life sciences innovation
since 1963
• 2007 Facility of the Year
Category Award Winner for
Facility Integration
9
10. PART OF THE COOK GROUP
ABOUT COOK GROUP, INC.
10
15. COMPELLING BUSINESS MODEL
Consolidate the product supply chain to a single location to simplify the process and reduce the cost and time
of managing and manufacturing with multiple service providers.
SIMPLIFY YOUR SUPPLY CHAIN WITH:
• ONE supplier to audit
• ONE point-of-contact for everything
• ONE quality system
• ONE set of business practices
• ONE contract
• ONE world-class, FDA-licensed manufacturing facility
15
16. Cook Pharmica’ s partnership with Ivy
Tech Bloomington
• Cook Pharmica and Ivy Tech’s biotechnology program are both established at the same time in year 2004
• Understanding and development of mutually beneficial partnership:
– Workforce development need (Cook Pharmica) – hiring of interns, technicians, and operators through Ivy
Tech’s education programs (tuition reimbursement program)
– Curriculum development need (Ivy Tech) – jobs, tasks, and skills set assessment for new educational
program development (course objectives and contents are developed based on essential skill sets required
by the jobs at Cook Pharmica),
– Instructional need (Ivy Tech) – subject matter experts at Cook Pharmica taught Ivy Tech courses as adjunct
faculty members (Cell Culture, Protein Purification, Safety and Regulatory Compliances, Biotechnology
Manufacturing topics), at least 12 Cook Pharmica employees taught at Ivy Tech
• Guaranteed course quality: the most practical and needed education contents
• The instructors from Cook Pharmica provided Ivy Tech’s students with early career assessment and job
interview opportunities
– So far, Cook Pharmica has offered 28 internship opportunities and hired 25 graduates
– Positions held by Ivy Tech graduates: Quality Control Technicians, Quality Assurance Assistants, Process
Development Scientists, Manufacturing Operators, and Instrumentation Technicians.
16
17. David’s experience and future prospective as the HR director:
• Difficulty in identifying and recruiting talent and
importance of homegrown workforce that will stay
within the community (community college graduates)
• Background/experience of Ivy Tech graduates
compared to traditional 4-year university graduates
• How Cook Pharmica’ s HR practice supports hiring of
Ivy Tech graduates: career advancement opportunity
for Ivy Tech graduates (example of Tony Roberts)
• What your career at Cook depends on: Performance,
Interests, Business Need.
• Importance of soft skills
17
18. Kenneth E. Miller, Ph.D.
Professor and Chair, Anatomy and Cell Biology
Oklahoma State University Center for Health Sciences
Diana Spencer, Ph.D.
Biotechnology Coordinator, Associate Professor
Tulsa Community College Southeast
Tulsa, OK
23. The National Science Foundation awarded a grant of
$384,581 to Tulsa Community College for the
Stimulating Enthusiasm, Exploration, and Discovery
through Biotechnology Education (SEEDBEd) project.
24. The Oklahoma IDeA Network of Biomedical Research
Excellence (OK-INBRE) is funded through the National
Center for Research Resources (NCRR), a component of
the National Institutes of Health (NIH) ($0.5M)
25. In the fall of 2011, the Oklahoma IDeA Network of
Biomedical Research Excellence (OK-INBRE) provided
$33,867 to Tulsa Community College to support a
supplemental grant, Sustaining Outreach of Learning
Experiences in Biotechnology Education (SOLEBEd) under
the direction of Dr. Diana Spencer
27. 2003 - They say education is the lighting of a fire. If that’s
true, doctoral candidate Diana Spencer has ignited many a
bright flame. A high school anatomy and physiology
teacher, she is on sabbatical from Jenks High School to earn her
doctorate in biomedical sciences at the OSU Center for Health
Sciences. Before she returned to school herself, she brought
dozens of students through the doors of the OSU-CHS to show
them what a medical school is all about.
Relationships
28. The National Science Foundation awarded a
grant of $384,581 to Tulsa Community College for
the Stimulating Enthusiasm, Exploration, and
Discovery through Biotechnology Education
(SEEDBEd) project.
Advisory Committee – OSU-CHS members: Drs.
Earl Blewett and Kenneth Miller
Support
30. Symposia/Seminars
Dr. Robert W. Allen, OSU-CHS
• Monthy Seminar Series, televised
• Annual High School Extravaganza
• Into a Molecular Future: Tulsa’s
Growth Opportunities in the New
Sciences of Life-Bio-Nano
35. Reciprocal Instruction
Dusti Sloan, Assistant Professor of
Biology, Teaching Cell Culture
techniques. Dusti Sloan is currently a
Ph.D. student in Biomedical Sciences
at OSU-CHS
Dusti
Sloan
Heith Crosby
Heith Crosby learning
cell culture
40. Collaborations
TCC SE Biotechnology Class
Peripheral Pain Mechanisms:
The Role of Glutamate
Kenneth E. Miller, PhD
Professor & Chair; Anatomy & Cell Biology
Oklahoma State University Center For Health Sciences
Tulsa, OK
Kemmx Corporation, Sapulpa, OK
March 2013
41. Relationships
3. Are there specific Oklahoma companies that are incorporating
bioscience innovations into their work?
Oklahoma's bioscience sector continues to grow, with the combined
direct and indirect impacts contributing $6.7 billion in economic
activity in the region. To describe a few companies specifically, …
Kemmx is centered here in Tulsa, and its objective is to bring to
market a topical analgesic for rheumatoid arthritis. PharmSci
Consulting has hired a couple of our graduates for work in Tulsa …
5 Questions with
Diana Spencer
By ROBERT EVATT
Tulsa World Staff
Writer on Dec 9,
2011
42. 42
Better Models. Better Results™
Developing Successful Community
College – Industry Partnerships
4-22-13
43. Better Models. Better Results™
A Leader in Genetic Modification for Drug
Discovery
Animal Models
Cell Lines
Life Sciences Research Reagents
Human Therapeutics
44. • DNA Modification Technology
– piggyBac TM for nearly all commercial applications
– XTNTM site-specific nuclease technology
• Stem Cell Technology
– induced Pluripotent Stem Cells (iPS)
– Spermatogonial stem cells (SSCs) and media
Transposagen Technology
45. Custom Services Overview
• Gene editing with XTNTMs, HR vector, piggyBac Transposon
– Site-specific knockout, knock-in, edit and correction of any gene
in any genome
• Animal models
– Rat and mouse model generation available, additional species
possible
47. Future Projects
• Life Sciences Collaborative Educational
Learning Laboratory (LIFE-CELL)
– Train up to 50-60 scientists per year
– Incubate up to 7 life science companies
– CRO function
