2. Issues and Opportunities in the Pharmaceutical Industry
Issues Opportunities
• Do I get a benefit? • I see my therapy helping
Patient • I know I get side effects • I am more in control
• Is it worth it? • I am rewarded for success
• What are the right drugs and doses? • Patient-specific therapy
Physician • Little time, too much to diagnose • Efficient, positive office visits
• Is it worth it? • Focus on the right patients and issues
• Is the branded drug necessary? • Objective measurement of benefit
Payer • Most drugs don’t work over time • Post-market risk assessment
• Is it worth it? • Empowered members are happy/quiet
Overall • Dubious value, lack of trust, no • Measured value, aligned goals, enduring
sustainable product loyalty connection to product system
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3. Proteus Snapshot
Company Overview
Founded in 2001
Total of $115 million in financing (Carlyle, EWHV, Kaiser Permanente, Medtronic, St. Jude,
Itochu, Novartis, ON Semiconductor, others)
Unique organization
Novel integrated circuit, MEMS and sensor design for custom medical applications
Signal processing and software development for intra-body communication
Product design, development and manufacturing from bench to clinical investigation
Physician and
Nurse
Remote
Strategic partnerships with global pharmaceutical and medical devices companies
Connectivity
300+ patent filings
Patient
3 programs in clinical trials
Personal
Support
Group
Medical
Connectivity
Named a Technology Pioneer by the World Economic Forum and a Top 10 Technology
Records
Breakthrough in 2008 by Wired Magazine
First product launch 2012
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4. Proteus Approach: The “Networked Pill”
Incorporate sensors into existing drugs; measure therapy delivery and its effect on
individual patients
Use this information, wellness tools and communication technologies to improve
patient care and outcomes
Increase productivity of clinical caregivers
Include and acknowledge the family caregiver
Empower patients and treat them like consumers
Build on existing reimbursement driven revenue models
Deliver greater medico-economic value to support reimbursement model
Build direct connection to family and consumer to support subscription model
Leverage network effects to maximize overall franchise revenue potential
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6. Networking the Daily Pills You Already Take
Proteus Ingestible Event Marker (IEM)
• Single < 1mm chip
• Senses and signals unique
identifier when swallowed
• Accurate: >97% detection in
human clinical trials
• Safe: made from ingredients
in food
• Cheap: 250,000 produced on
$1,000 wafer
• Private: EKG-like signal
conducted only in body
Enables Device-Based Sensing and Monitoring of Pharmaceuticals
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7. Monitoring via a Band-Aid Familiar to Consumers
• Wearable sensing device
− Sensors for intelligent
pharmaceuticals
− Sensors for physiological
response
• Sensing of drug ingestion,
HR, respiration, physical
activity and body angle
Enables Continuous Correlation of Therapeutic Event and Response
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9. Summary: Raisin Enables Truly Personal Personalized Medicine
• Combines behavioral and physiologic data at individual patient level
• Customizable and collaborative care tool to affect behavior change
• Compatible with other disease management devices
• Consistent with global business and social trends
• Anywhere, anytime mobile connectivity
• Personal healthcare responsibility
• Social networking and online health communities
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