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Metabolic and genetic bone diseases dina patho
1. Osteogenesis imperfecta.
A. Opalescent dentin in a patient with osteogenesis imperfecta.
B. Bite-wing radiograph of the same patient showing shell teeth with thin dentin
and enamel of normal thickness.
4. Osteopetrosis. This 24 -year-old white man has the infantile form of
osteopetrosis. He has suffered from mandibular osteomyelitis And multiple
draining fistulae are present on his face.
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8. Osteopetrosis. Low-power photomicrograph showing sclerotic bone that is replacing the
normal cancellous bone. The inset shows a nodular pattern of the dense bone obliterating
the marrow spaces.
13. Idiopathic osteosclerosis. A. An asymptomatic area of bane sclerosis is seen
between and apical to the roots of the first and second mandibular molars. B, no
appreciable change can be seen on this radiograph taken 10 years later.
15. Bone scar. Residual area of increased radiodensity
in the area of extraction of the mandibular first molar.
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19. Paget's disease. Lateral skull film shows marked enlargement of the cranium
with new bone formation above the outer table of the skull and a patchy, dense,
"cotton wool“ appearance.
22. Paget's disease. Prominent osteoblastic and osteoclastic
activity surround the bone trabeculae. Note the resting and
reversal lines.
23. Giant cell tumor. This photomicrograph shows large giant cells that are
distributed in a cellular mesenchymal tissue. This specimen was froman
aggressive lesion that had destroyed most of the maxilla.
24. Massive osteolysis. Periapical radiograph showing an ill-defined radiolucency
associated with vital mandibular teeth.
Note the loss of lamina dura.
25. Massive osteolysis. Panoramic radiograph of the same patient, showing
extensive bone loss and a pathologic fracture of the left mandible. This
destruction occurred over an 8-month period.
26. Massive osteolysis. Biopsy specimen from the same patient. The loose.
Highly vascular connective tissue shows a diffuse chronic
inflammatory cell infiltrate.