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Uksri research proposal stratton
1. 2011 Research Project
Application Form
This application form may be typewritten or handwritten. If handwritten, it should be
completed in block capitals and black ink, using additional paper where required. The form
may also be completed by reproducing the questions, with answers, on your own word
processing system.
Part or all of the information you provide will be held on computer.
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2. Section Two – Proposal Application
Research Proposal Area:
Chiral molecules (chiral switching), drug synergy, and Cyclopyrrolones (especially non-
benzodiazepines ("Z-drugs")
Research Title:
Amplifying the effectiveness of Cyclopyrrolones (e.g. Zopidone Lunestra), and other chiral molecules
through chiral switching and recombinant drug technology
Research Overview: (500 words or less)
Drug effectiveness through drug synergy is the next frontier in medicine. Rather than spending
wasted money and time searching for new and unproven drugs, amplifying the already existing effect
could prove to be beneficial in many ways. The possible benefits of finding a universal serum are
limitless; from reducing the need of large drug dosages to decreasing the number of times a drug
needs to be administered. Increasing the effectiveness of a drug could help those in environments
where resources and time are limited and restrained (such as military personal in the field or those
exploring remote areas or environments where delivery of drug serves as a disruption).
I have been researching the effectiveness of hypnotic (soporific) psychoactive chiral molecules such
as Cyclopyrrolones (e.g. Zopiclone), and herbal substances that have been in use in Vodun rituals.
Through chiral switching, the production of single enantiomers can lead to a reduction in side effects
and toxicity as well as increasing dose effectiveness. If a recombinant process could be used to
produce a universal enantiomer (comparable to chimera plastids in DNA recombinant drugs), this
could lead to a base, universal unlocking agent that when combined with most drug structures would
prolong the effect and transmit the usefulness of the drug further in the human system providing a
fundamental shift in how the human immune system deals with disease. We could equip humans with
the mechanism to enhance any substance introduced into the system.
Section Three – Referees
Referees:
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3. I confirm that the person named at Section 1 is authorised to act as the contact in all
matters relating to this application.
Referee 1
Full Name:
Address:
Relationship to you:
Signature:
Referee 2
Full Name:
Address:
Relationship to you:
Signature:
PLEASE KEEP A COPY OF THIS FOR YOUR OWN PERSONAL REFERENCE
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