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Estimation of the alpha / beta ratio for lung injury based on direct measurements of radiotherapy (RT)-induced reductions in regional perfusion in human patients Bridget Koontz, Su-min Zhou, Elizabeth Evans, Zeljko Vujaskovic, Ron Jazczack, Terence Wong, and Lawrence Marks Department of Radiation Oncology, Duke University Medical Center, Durham, NC USA  ,[object Object],[object Object],[object Object],[object Object],1/ED50 VERSUS FRACTION SIZE:   Effect  α  D (a + bd)  1/D  α  a + bd    y-intercept = alpha   slope = beta  100 evaluable lung cancer patients with  pre and post RT SPECTs   ,[object Object],[object Object],[object Object],32 patients selected for unique beam arrangement, dose/fx, total dose   2 QD  12 pts  24 beams 1.8  QD  2 pts  3 beams Supported by NIH Grant CA069579 Acknowledgement ro UNC-CH for use of PLUNC 35 cGy/fx 160 cGy/fx 125 cGy/fx Pre-RT Post-RT Quantify perfusion loss for each dose regimen Alpha/beta  ≈  1.6-3.1 Based on the beam arrangement used, areas of lung receiving specific doses per fraction were identified   (Gy) 1.6  QD  1 pt  1 beam 1.6  BID  10 pts  10 beams 1.25 BID  4 pts  4 beams 0.35 BID  4 pt s  4 beams Data fit using 3 models ED50 = 62 Gy ED50 = 52 Gy ED50 = 19 Gy ED50 = 42 Gy ED50 = 34 Gy Total Dose (Gy) Total Dose (Gy) Total Dose (Gy) Total Dose (Gy) ED50 = 50 Gy Total Dose (Gy) Total Dose (Gy) Using % perfusion reduction at maximum population volume, estimated dose causing 50% perfusion reduction

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Alpha Beta Ratio For Lung

  • 1.