Iso Allo Idio 2001

Immunoglobulin: Isotypes, Allotypes and Idiotypes

Immunoglobulin Isotypes ,[object Object]

Human IgM antiserum Reacts with IgM, IgG, IgA, IgD, IgE React with IgG, IgA, IgD and IgE Absorbed antiserum Reacts only with IgM Recognizes determinants specific for  heavy chains (isotypes) Immunoglobulin Isotypes ?? ?? ??

Immunoglobulin Isotypes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],IgM (kappa) IgG1 (kappa)

Immunoglobulin Allotypes ,[object Object],[object Object],[object Object],[object Object],[object Object],IgG1 (kappa) Person 2 IgG1 (kappa) Person 1

Human Immunoglobulin Allotypes ,[object Object],[object Object],[object Object]

Human Immunoglobulin Allotypes ,[object Object],[object Object],[object Object],Km(1)/Km(3) X Km(1)/Km(1) Km(1)/Km(1) and Km(1)/Km(3) ,[object Object]

[object Object],[object Object],Human Immunoglobulin Allotypes G1m(17) G1m(1) 214 355-358

Immunoglobulin Allotypes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Immunoglobulin Idiotypes ,[object Object]

DNP-BSA Strain A Mouse Anti-DNP Ab Purified anti-DNP Ab Strain A Mouse Ab against combining site of anti-DNP Ab ?? Immunoglobulin Idiotypes Antigenic determinants created by the HVR = Idiotypes

Immunoglobulin Idiotypes ,[object Object],[object Object],IgG1 (kappa) Person 1 anti-B IgG1 (kappa) Person 1 anti-A

Immunoglobulin Idiotypes ,[object Object],[object Object],[object Object],[object Object],[object Object]

Ag Id anti-Id + - anti-anti-Id + - Regulation by Id/anti-Id

Immunoglobulin Idiotypes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Anti-Idiotype Vaccines Ag Id anti-Id + - Ag Id anti-Id +

Immunoglobulin Idiotypes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Iso Allo Idio 2001

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Iso Allo Idio 2001