1. Antituberculosis Drugs

9. Drug name Dosage / Route Usual Indications Capreomycin (Capastat) Adult: 1g/day IM for 60-120 days, followed by 1g IM 2-3 times per week for 18024 mo; reduce dosage with renal impairment Pediatric: 15 mg/kg/day IM Second-line drug for treatment of Mycobacterium tuberculosis Cycloserine (Seromycin) Adult: 250 mg PO b.i.d. for 2 wk, then 500 mg to 1 g/day PO in divided doses Pediatric: safety not established Second-line drug for treatment of Mycobacterium tuberculosis

10. Ethambutol (Myambutol) Adult: 15 mg/kg/day PO as a single dose Pediatric: not recommended for children < 13 yr. Second-line drug for treatment of Mycobacterium tuberculosis Ethionamide (Trecator S.C.) Adult: 15-20 mg/kg/day PO in divided doses with pyridoxine Pediatric: 10-20 mg/kg/day PO in divided doses with pyridoxine First-line drug for treatment of Mycobacterium tuberculosis Isoniazid (INH) (Nydrazid) Adult: 5 mg/kg/day PO Pediatric: 10-20 mg/kg/day PO First-line drug for treatment of Mycobacterium tuberculosis

11. Pyrazinamide (Generic) Adult and Pediatric: 15-30 mg/kg/day PO Second-line drug for treatment of Mycobacterium tuberculosis Rifabutin (Mycobutin) Adult: 300 mg PO daily Pediatric: safety not established Treatment of Mycobacterium avium-intracellulare (MAC) in patients with advance HIV infection Rifampin (Rifadin, Rimactane) Adult: 600 mg 2 times per week for 2 mo Pediatric: safety not established First-line drug for treatment of M. tuberculosis Rifapentine (Priftin) Adult: 600 mg PO 2 times per week for 2 mo Pediatric: safety not established First-line drug for treatment of M. tuberculosis