Enzymes In Diseases

MEDICAL APPLICATION OF ENZYMES HARIS P MSC BIOTECHNOLOGY MA COLLEGE ERNAKULAM

Medical Application ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

THERAPEUTIC APPLICATION Enzyme Reaction use ,[object Object],Starch hydrolysis Diagestive disorders Collagenase Collagen hydrolysis Skin ulcers Ficin, Papain, Proteinase Protein hydrolysis Deworming, digestive -disorders,narcotic tissue removal Glutaminase Gln  Glu Leukemia Asparginase Asn  Asp Leukemia Lysozyme Bacterial CW hydrolysis As Antibiotics Bilirubin oxidase Bilirubin hydroxylase hyperbilirubinemia Enzyme Reaction Use Rhodanase Degradation of cyanide Cyanide poisoing RNase RNA digestion Antiviral RNA hydrolysis  lactamase Pencillin  Pencilloate Pencillin allergy Streptokinase/urokinase Plasminogen  plasmin Blood clot dissolving uricase UA  allatoin Gout Hyaluronidase ?HUA hydrolysis Viral infection SOD 2O2+2H+  H2O2+O2 antioxidant/antiinflammatory urease Urea hydrolysis Hyperureamia Arginase Arginine hydrolysis Cancer

ENZYMES IN DISEASES Organ Enzymes Diseases Liver ALP,GDH,SGOT,SGPT,Glutamyl Tranferasess,Glutathione S Tranferases, Viral/toxic hepatitis or cirrhosis, myocardial infraction,jaundice, Heart Creatne Kinases,LDH, AST/ALT, Myocardial Infraction , skelital muscle disorders. Other diseases Amylases,Aldolases,TG Lipases,CK,ALP,ACP,Choline Esterases,HMG CO A Reductases,Xanthine Oxidases, GIT disorders, jaundice,bone diseases, rickets,

Enzyme Deficiency Disorders ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

ENZYME DEFICIENCY DISEASES Diseases Enzyme Gout (X linked recessive) PRPP Synthase Lesch Nyhan Syndrom hypoxanthine-guanine- Phosphoribosyl transferase Cystic fibrosis DNase Alcaptonuria Homogentisate oxidase Maple syrup urine disease (various forms Branched-chain ketoacid dehydrogenase Immunoinsufficiency( autosomal Recessive) Adenosinedeaminase Disease Enzyme Tay-Sachs disease hexosaminidase A Krabbe's disease b-galactosidase Niemann-Pick disease sphingomyelinase Farber's disease ceramidase Fabry's disease a-galactosidase Alcaptonuria homogentisate oxidase Gauchers desease b-glucosidase Lactose intolerance Lactase

Use of Enzymes in determination of Metabolites of clinical importance ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Enzyme inhibitors & Drug Design Drug/Inhibitor Enzyme Disease Mevinolin, Copactin, Monacolk HMG CoA Reductase Hypercholesteremia Penicillins & antibiotics Peptidyl transferase, RNA polumerases,DNA Polymerases etc. Infections after Surgery,Other infectious diseases Allopurine Xanthine Oxidases Gout, Hyperureamia HIV Protease Inhibitors HIV Proteases AIDS Methotrexate Folate reductase Cancer,infections Ethanol Alcohol Dehydrogenase Methanol poisoning,

CANCER THERAPY PRODRUG DRUG ENZYME Methotrexate  phe. methotrexate Carboxy peptidase A Etoposide phosphate Etoposide ALP  N bis 2-chloroehyl aminobezoyl glu. Benzoic acid mustard Carboxypeptidase-G2 Mtomycin phosphate mitomycin ALP Aniline mustard glucuronide Aniline mustar Glucuronidase 5-flurrocytosine 5-flurouracinl Cytosine deaminase 2 L  amino acyl methotrexate mmethotrexate aminopeptidase

Assay of Plasma Enzymes ,[object Object],[object Object],[object Object],[object Object],[object Object]

ENZYME IMMUNO ASSAY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Enzymes In Diseases

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