Analytical methods development and validation play important roles in the discovery, development, and manufacture of pharmaceuticals. The current good manufacturing practice (cGMP) and Food Drug Administration (FDA) Guidelines insist for adoption of sound methods of analysis with greater sensitivity and reproducibility. This thesis describes analytical methods developed for drug determination in pharmaceutical dosage forms and biological matrixes including Chromatography (RP-HPLC) and Hyphenated Techniques (LC-MS/MS). Methods have been developed for separation and quantification of selected drugs from categories like Antihypertensive, Antihyperlipidemic, Skeletal Muscle Relaxant, Non-Steroidal Anti-inflammatory Drug (NSAID), Antibiotic, Anticonvulsant, Antiviral, and Analeptic.

1. By Prafulla Kumar Sahu

2. Development and Validation of Analytical Methods
for the Assay of Selected Drugs in Pharmaceutical
Dosage forms and Biological fluids
LAP Lambert Academic Publishing ( 2011-10-25 )
Book Details:
ISBN-13: 978-3-8443-2869-1
ISBN-10: 3844328696
EAN: 9783844328691
Book language: English
By (author) :
Prafulla Kumar Sahu
M. Mathrusri Annapurna
Number of pages: 352
Published at: 2011-10-25
Category: Pharmacy

3. Abstract for the book
Analytical methods development and validation
play important roles in the discovery,
development, and manufacture of
pharmaceuticals. The current good
manufacturing practice (cGMP) and Food Drug
Administration (FDA) Guidelines insist for
adoption of sound methods of analysis with
greater sensitivity and reproducibility. This
thesis describes analytical methods developed
for drug determination in pharmaceutical
dosage forms and biological matrixes including
Chromatography (RP-HPLC) and Hyphenated
Techniques (LC-MS/MS). Methods have been
developed for separation and quantification of
selected drugs from categories like
Antihypertensive, Antihyperlipidemic, Skeletal
Muscle Relaxant, Non-Steroidal Anti-
inflammatory Drug (NSAID), Antibiotic,
Anticonvulsant, Antiviral, and Analeptic.

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6. Analytical Method Development by
Liquid Chromatography
Thank You
Development and validation of Analytical Methods for the Assay
of drugs in Pharmaceutical dosage forms and Biological fluids